Bioequivalence study of dacomitinib and Vizimpro® in healthy Chinese volunteers under fasting and fed conditions: A randomized, open-label, single-dose, crossover trial [0.03%]
达可替尼片与Vizimpro?在中国健康受试者中的生物等效性研究：一项随机、开放、单次给药、餐后及空腹条件下的人体生物等效性试验
Xiaojia Yang,Jinfang Li,Taihui Zhang et al.
Xiaojia Yang et al.
This study aimed to evaluate the bioequivalence between test tablet dacomitinib and reference product Vizimpro® under fasting and fed conditions and assess their pharmacokinetic (PK) and safety profiles for gaining marketing approval of th...
Randomized Controlled Trial
Clinical and translational science. 2023 Dec;16(12):2591-2603. DOI:10.1111/cts.13653 2023
Lidocaine as an anti-arrhythmic drug: Are there any indications left? [0.03%]
利多卡因作为抗心律失常药物：还有哪些适用指征？
Sati Güler,Hilke Könemann,Julian Wolfes et al.
Sati Güler et al.
Lidocaine is classified as a class Ib anti-arrhythmic that blocks voltage- and pH-dependent sodium channels. It exhibits well investigated anti-arrhythmic effects and has been the anti-arrhythmic of choice for the treatment of ventricular a...
Serum HMGB1 is a biomarker for acute myocardial infarction with or without heart failure [0.03%]
血清HMGB1是急性心肌梗死伴或不伴有心力衰竭的生物标志物
Abdul Wahid,Juan Wen,Qiong Yang et al.
Abdul Wahid et al.
This study measured serum high mobility group box 1 (HMGB1) levels in patients with acute myocardial infarction (AMI) and/or heart failure (HF) and evaluated their relationship with peripheral inflammatory biomarkers and cardiac biomarkers,...
A first-in-human phase I study of SHR-1906, a humanized monoclonal antibody against connective tissue growth factor, in healthy participants [0.03%]
SHR-1906（抗连接素人源化单克隆抗体）在健康受试者中的I期临床研究
Lin-Lin Song,Hai-Yan Zhou,Pan-Pan Ye et al.
Lin-Lin Song et al.
New therapeutic targets and drugs are urgently needed to halt the fibrosing process in idiopathic pulmonary fibrosis (IPF). SHR-1906 is a novel fully humanized monoclonal antibody against the connective tissue growth factor, which plays an ...
The presence of busulfan metabolites and pharmacometabolomics in plasma drawn immediately before allograft infusion in hematopoietic cell transplant recipients [0.03%]
_busulfan代谢产物及药代代谢组学在造血细胞移植受者异体植入前即刻采集血浆中的检出
Jeannine S McCune,Sandi L Navarro,Linda J Risler et al.
Jeannine S McCune et al.
Busulfan is hepatically metabolized through glutathione (GSH) conjugation; in vitro, this process depletes hepatocyte GSH stores and generates the cytotoxic metabolite γ-glutamyldehydroalanylglycine, which is too unstable to be quantitated...
Effect of vitamin D supplementation on circulating level of autophagosome protein LC3A, inflammation, and physical performance in knee osteoarthritis [0.03%]
维生素D补充对膝关节炎患者自噬溶酶体蛋白LC3A水平、炎症及身体机能的影响：一项随机对照试验
Wacharapol Saengsiwaritt,Jiraphun Jittikoon,Usa Chaikledkaew et al.
Wacharapol Saengsiwaritt et al.
Aberrant autophagic activity is observed in osteoarthritic joints. Vitamin D was shown to alleviate not only osteoarthritis severity, but also autophagy process. However, the influence of vitamin D on autophagy in knee osteoarthritis (KOA) ...
Dose selection for biological enzyme replacement therapy indicated for inborn errors of metabolism [0.03%]
用于治疗先天性代谢缺陷的生物酶替代疗法的剂量选择
Yuen Yi Hon,Jie Wang,Henrietta Abodakpi et al.
Yuen Yi Hon et al.
This paper summarizes key features of the dose-finding strategies used in the development of 11 approved new molecular entities that are first-in-class enzyme replacement therapy (ERT), with a goal to gain insight into the dose exploration ...
The "One-Step" approach for QT analysis increases the sensitivity of nonclinical QTc analysis [0.03%]
“One-Step”法提高非临床QT/QTc研究敏感性的潜力
Derek J Leishman,David L Holdsworth,D Adam Lauver et al.
Derek J Leishman et al.
Whether a compound prolongs cardiac repolarization independent of changes in beat rate is a critical question in drug research and development. Current practice is to resolve this in two steps. First, the QT interval is corrected for the in...
Assessing pharmacogenomic literacy in China through validation of the Chinese version of the Minnesota Assessment of Pharmacogenomic Literacy [0.03%]
通过明尼苏达州药理基因组学素养评估工具的中国版验证在中国评估药理基因组学素养
Lusi Zhang,Shuqin Zhou,Josiah D Allen et al.
Lusi Zhang et al.
Pharmacogenomics (PGx) implementation into clinical care is rapidly increasing in China. However, the extent to which the public understands PGx testing and important knowledge domains requiring patient education or counseling remains uncle...
Physiologically based absorption modeling to predict the bioequivalence of two cilostazol formulations [0.03%]
基于生理的吸收模型预测西洛他唑两剂型生物等效性
Lu Wang,Pengfei Zhao,Ting Luo et al.
Lu Wang et al.
In vivo pharmacokinetic simulations and virtual bioequivalence (BE) evaluation of cilostazol have not yet been described for humans. Here, we successfully developed a physiologically based absorption model to simulate plasma concentrations ...