A Randomized, Double-Blind, Placebo-Controlled Phase 1 Study of Adiponectin Agonist (PEG)-BHD1028 in People With Insulin Resistance [0.03%]
BHD1028-Peg修饰的脂联素激动剂治疗胰岛素抵抗人群的I期随机双盲安慰剂对照研究
Pablo Lapuerta,Brian B Kim
Pablo Lapuerta
Low adiponectin levels may contribute to insulin resistance. This first-in-human study evaluated adiponectin receptor agonist (PEG)-BHD1028 in subjects with insulin resistance. Adults with BMI ≥ 27 kg/m2, HOMA-IR ≥ 1.8, and HbA1c < 6.5% r...
The Effect of Efavirenz and Rufinamide on the Pharmacokinetics and Safety of Quizartinib: Two Phase 1 Studies in Healthy Participants [0.03%]
艾法维恩兹和吕非喃胺对Quizartinib药代动力学及安全性影响的研究：健康参与者中的2项I期研究
YoungJun Yoo,Hamim Zahir,Shinichi Inaba et al.
YoungJun Yoo et al.
Quizartinib is an oral, potent, selective FMS-like tyrosine kinase 3 (FLT3) inhibitor, approved for the treatment of FLT3-internal tandem duplication (ITD)-positive acute myeloid leukemia (AML) and under investigation in patients with newly...
Real-World Clinical Datasets in Practice: Applications for Learners, Clinician-Educators, and Health Services Teams [0.03%]
真实世界临床数据集的应用：学员、临床教育工作者和卫生服务团队的实践体验
Jacob F Wood,Jacob J Tan,Hunter M Eby et al.
Jacob F Wood et al.
Real-world clinical databases offer students, residents, fellows, clinician-educators, librarians, and early-career investigators an accessible entry point into population health, quality improvement, and outcomes research. Leveraging large...
Reply to "Preclinical and Clinical Evidence on Chloroquine or Hydroxychloroquine in COVID-19": Achieving Statistical Significance Does Not Mean That Clinical Relevance Can Be Disregarded, and This Must Be Considered When Interpreting Results [0.03%]
关于“抗新冠病毒药物氯喹和羟氯喹的临床前与临床证据”的回复：实现统计学意义不等于可以忽略临床相关性，解读结果时必须考虑这一因素
Inès Ben Ghezala,Marc Bardou
Inès Ben Ghezala
The Inflammatory Response in the Murine Ovalbumin-Induced Skin Inflammation Model Is Robust Despite Major Gut Microbiota Differences [0.03%]
尽管肠道微生物群存在重大差异，小鼠卵清蛋白诱导的皮肤炎症模型中的炎性反应仍然明显
Ida Wang Henriksen,Christina Bartholdy,Janne Koch et al.
Ida Wang Henriksen et al.
Valid pre-clinical animal models are essential for effective drug development in inflammatory skin diseases like atopic dermatitis. Most murine models exhibit low-to-moderate inflammatory responses with significant variability, undermining ...
Respiratory Biomarkers: An Opportunity for Patient-Centric Microsampling Approach for Treatment Optimization [0.03%]
呼吸道生物标志物：以患者为中心的微采样方法优化治疗的机会
Ahmar Khan,Jacqueline L Stair,Daniel Baker et al.
Ahmar Khan et al.
The clinical heterogeneity of respiratory disorders emphasizes the need for personalized approaches to prevention, diagnosis, and therapy. One approach to enhanced personalization of therapy is the identification of biomarkers for disease p...
Human Absorption, Metabolism, and Excretion (hAME) Mass Balance Studies in Patients With Cancer [0.03%]
癌症患者中的人体吸收、代谢和排泄(MBE)平衡研究
Begoña de Las Heras,Claudine Oelke,Pamela Atwell et al.
Begoña de Las Heras et al.
Radiolabeled mass balance human studies are a critical component of clinical pharmacology programs supporting the development of new investigational drugs. These studies provide information about absorption, metabolism, and excretion (AME) ...
Ida W Henriksen,Camilla H F Hansen,Janne Koch et al.
Ida W Henriksen et al.
Fecal microbiota transplantation (FMT) in mice is an evolving research field, often employing oral gavage, which can be stressful and harmful for the animals and time-consuming for technicians. Voluntary intake methods, such as delivery in ...
Comparative Study
Clinical and translational science. 2026 Jun;19(6):e70576. DOI:10.1111/cts.70576 2026
Ramesh R Boinpally,Joel M Trugman
Ramesh R Boinpally
The aim of this study was to determine the cerebrospinal fluid (CSF) to plasma concentration ratio of atogepant. Healthy adult participants (N = 28) were enrolled into this phase 1, open-label study and received atogepant 60 mg once daily f...
Clinical Trial
Clinical and translational science. 2026 Jun;19(6):e70610. DOI:10.1111/cts.70610 2026