Exploring the Antimicrobial Efficacy of Mesenchymal Stem Cell Secretome Against Klebsiella pneumoniae in Urinary Tract Infections [0.03%]
探究间充质干细胞分泌组对抗尿路感染肺炎克雷伯菌的抗菌疗效
Leen Ali,Elie Salem Sokhn,Charbel Khalil et al.
Leen Ali et al.
Antimicrobial resistance (AMR) has become a global health crisis, with Klebsiella pneumoniae (K. pneumoniae) emerging as a major driver of AMR and a leading cause of urinary tract infections (UTIs). Mesenchymal stem cell (MSC)-derived secre...
A Bayesian-Based Integrative Bioinformatics Analysis Nominates Oncogenic Drivers in Neuroblastoma [0.03%]
基于Bayesian的综合生物信息学分析确定神经母细胞瘤中的致癌驱动基因
Lin Xu,Arhanti Sadanand,Evan W Neczypor et al.
Lin Xu et al.
Identifying targetable oncogenic drivers remains a challenge in neuroblastoma, the most common extracranial solid malignancy in children. We applied a Bayesian algorithm for integrative analysis of expression and copy-number, iExCN, to nomi...
Correction to "Impact of CYP2D6 Genotype and Inhibitor Use on Risperidone Metabolism in Children: Functional Insights Into the *17 and *29 Alleles" [0.03%]
有关CYP2D6基因型和抑制剂对利培酮代谢影响的更正：“在儿童中*17和*29等位基因的功能学启示”
Published Erratum
Clinical and translational science. 2026 Jun;19(6):e70641. DOI:10.1111/cts.70641 2026
Characterization of Urinary Kidney Injury Biomarker Profiles in Healthy Japanese Subjects With Reference to a Counterpart US Study [0.03%]
参考美国对照试验在日本健康人群中的肾损伤生物标志物谱型特征分析研究
Takehiko Sambe,Takuya Mizukami,Nicholas M P King et al.
Takehiko Sambe et al.
Drug-induced kidney injury should be monitored throughout the drug development process to ensure patient safety. Standard kidney injury biomarkers may not always correlate with subtle microscopic histopathological kidney injury. Standard bi...
tVNS Mitigates Neuroinflammation and Nociception in a Rodent LPS Endotoxemia Model [0.03%]
通过耳缘神经刺激减轻内毒素血症大鼠模型的神经炎症和痛觉异常
Kerem Atalar,Ece Alim,Aysen Calikusu et al.
Kerem Atalar et al.
The vagus nerve plays a modulatory role in the gut-brain axis. Intestinal barrier dysfunction and lipopolysaccharide (LPS) leakage into the systemic circulation are associated with several conditions, such as irritable bowel syndrome (IBS) ...
CYP2E1 and CYP2D6 in Anti-Tuberculosis Drug-Induced Liver Injury: Mechanisms, Epigenetic Regulation, and Translational Implications [0.03%]
细胞色素P450 2E1和细胞色素P450 2D6在抗结核药性肝损伤中的机制、表观遗传调控及转化意义
Pathida Prakongsup,Wanvisa Udomsinprasert
Pathida Prakongsup
Tuberculosis (TB) continues to be a significant global health issue, with anti-tuberculosis drug-induced liver injury (ATDILI) representing the most frequent and severe adverse event associated with first-line therapy. Despite extensive inv...
Eltrombopag Combined With Cyclosporine A in the Treatment of Pediatric Patients With SAA: Establishing the Range for Eltrombopag Concentrations [0.03%]
艾曲波帕联合环孢素A治疗重型再生障碍性贫血患儿建立艾曲波帕浓度范围
Fashuang Li,Na Li,Xiaoling Tang et al.
Fashuang Li et al.
Eltrombopag (ELT), as an oral thrombopoietin receptor agonist, in combination with cyclosporine A (CsA) provides a novel therapeutic option for pediatric severe aplastic anemia (SAA). However, current clinical protocols predominantly adopt ...
Tumor-Specific Success Probabilities and Factors Associated With Phase III Trials in Oncology Drug Development [0.03%]
肿瘤特异性成功率和III期临床试验的影响因素-以抗癌药物研发为例的研究
Keiko Yamamoto,Aya Iwase,Hideki Maeda
Keiko Yamamoto
Despite advances in novel therapeutic modalities, such as molecularly targeted agents and immunotherapies, the probability of success in Phase III oncology trials remains low. This study quantitatively characterized success probabilities of...
Mechanism-Based Polypharmacy as a Repurposing Strategy: The Case of D-Cycloserine and Lurasidone [0.03%]
基于机制的多靶点药物联合使用作为一种再定位策略：D-环丝氨酸和鲁拉西酮的例子
Avery D Franzen,John S Svendsen,Cassidy J Kline et al.
Avery D Franzen et al.
Modern psychiatric treatment often necessitates polypharmacy, yet combination regimens carry significant risks of metabolic burden and drug-drug interactions. There is growing interest in and clinical acceptance of rational, mechanism-based...
Pioneering a Hybrid Decentralized Clinical Trial in South Korea: Assessing Feasibility, Data Integrity, and Participant Perceptions [0.03%]
韩国先驱性混合去中心化临床试验：评估可行性、数据完整性和参与者感知
Eunwoo Kim,Sungyeun Bae,Ki Young Huh et al.
Eunwoo Kim et al.
Clinical trials with decentralized elements (DCTs) may improve accessibility and convenience by reducing the need for frequent on-site visits; however, empirical evidence remains limited. Within a Phase 1 pharmacokinetic drug-drug interacti...