Hypoxia-Induced Lineage Plasticity in Neuroblastoma: Advancing Signature Interpretation and Clinical Translation [0.03%]
神经母细胞瘤中的低氧诱导的谱系可塑性：推进标志解析和临床转化
Jimmy Carter Osei,Aya Abukwaik,Matteo Di Giovannantonio et al.
Jimmy Carter Osei et al.
A Multipart Phase 1 Study to Assess Safety and Pharmacokinetics of Ibuzatrelvir in Healthy Participants and Dose Selection for a Dose-Ranging Study [0.03%]
伊布扎特韦在健康受试者中的安全性和药代动力学多部分1期研究及剂量范围研究的剂量选择
Ravi Shankar P Singh,Sima S Toussi,Frances Hackman et al.
Ravi Shankar P Singh et al.
COVID-19 continues to be a threat to global health and a burden on healthcare systems. There is an ongoing need for COVID-19 antiviral therapies that are safe and effective across broad patient populations. Ibuzatrelvir is a potent, selecti...
Clinical Trial
Clinical and translational science. 2026 Jul;19(7):e70659. DOI:10.1111/cts.70659 2026
Lili Gao,Yan Wang,Ruirui He et al.
Lili Gao et al.
The paper systematically reviews the technical guidelines for Model-Informed Drug Development (MIDD) issued by China's Center for Drug Evaluation (CDE), analyzing typical application cases of innovative drugs approved both in China and inte...
Machine Learning With Genetic and Clinical Data to Predict Ischemic Outcomes After PCI [0.03%]
基于遗传和临床数据的学习算法预测PCI术后缺血性结局
Caroline W Grant,Brenden S Ingraham,Ryan J Lennon et al.
Caroline W Grant et al.
Ischemic events after contemporary percutaneous coronary intervention (PCI) are uncommon but carry high morbidity/mortality. Identifying patients at highest risk is critical to guide dual antiplatelet therapy (DAPT) intensity while minimizi...
Advancing PEGylated Drug Evaluation: A Novel Approach to Pegfilgrastim Pharmacokinetic Assessment [0.03%]
聚乙二醇化药物评价的进步：一种新的 pegfilgrastim 药物代谢动力学评估方法
Elizaveta Svyatova,Da Shi,Ankit Shah et al.
Elizaveta Svyatova et al.
Addition of polyethylene glycol (PEG), or PEGylation, is a modification that extends the half-life of drug products, thereby reducing the frequency of dosing. However, PEGylation can pose challenges for biosimilar drug development, as repli...
Development of Core Competencies in Clinical Data Science Graduate Education: A Follow-On Tutorial to From Clinical Data Management to Clinical Data Science: Time for a New Educational Model [0.03%]
临床数据科学研究生教育核心竞争力的培养：临床数据管理到临床数据科学的新教育模型研讨会的后续教程
Richard F Ittenbach,Courtney R McKeown
Richard F Ittenbach
This paper presents a structured framework for designing a competency-based curriculum in clinical data science graduate education and serves as a follow-on to the 2023 tutorial From Clinical Data Management to Clinical Data Science: Time f...
Population Pharmacokinetic, Exposure-Response Efficacy and Safety Analyses of Favezelimab in Patients With Solid Tumors [0.03%]
法西珠单抗治疗实体瘤患者的群体药代动力学、暴露量-效应和安全性分析
Mitali Gaurav,Heather Barcomb,Kelly F Maxwell et al.
Mitali Gaurav et al.
Favezelimab (MK-4280) is a humanized monoclonal antibody (mAb) targeting lymphocyte activation gene-3 (LAG-3). Favezelimab population pharmacokinetics (popPK) was evaluated using data from 2 trials; a Phase 1 study evaluating favezelimab ac...
Clinical Trial
Clinical and translational science. 2026 Jul;19(7):e70658. DOI:10.1111/cts.70658 2026
Development of a Biphasic Modified-Release Ibuprofen Tablet Formulation: Single-Dose and Multiple-Dose Pharmacokinetics and Food-Effect Studies [0.03%]
一种双相型缓释布洛芬片剂的开发：单次给药和多次给药动力学及食物影响研究
Ludmila Kvapilová,Jiří Hofmann,Josef Černý et al.
Ludmila Kvapilová et al.
Ibuprofen is the most commonly used NSAID; however, its short biological half-life, reflected in the short duration of pain relief, limits the comfortableness of its usage. This study evaluated the pharmacokinetic properties of a newly deve...
Randomized Controlled Trial
Clinical and translational science. 2026 Jul;19(7):e70654. DOI:10.1111/cts.70654 2026
Circulating M-MDSC Expansion During Therapy Associates With Treatment Response in Multiple Myeloma: A Longitudinal Observational Study [0.03%]
治疗过程中循环M-MDSC的扩增与多发性骨髓瘤患者的疗效相关：一项纵向观察研究
Qi Yan,Bin Chu,Mengru Liu et al.
Qi Yan et al.
Dynamic changes in myeloid-derived suppressor cells (MDSCs) during multiple myeloma (MM) treatment remain poorly understood. In this longitudinal observational study, circulating monocytic (M-MDSCs) and polymorphonuclear MDSCs (PMN-MDSCs) w...
Observational Study
Clinical and translational science. 2026 Jul;19(7):e70660. DOI:10.1111/cts.70660 2026