Harnessing Exhaled Breath for Lung Cancer Early Detection-Results From the ExPeL Study [0.03%]
利用呼出气体检测肺癌(EXPEL研究结果)
Danita Kasi Patel,Leon D&#x;Cruz,Waqar Ahmed et al.
Danita Kasi Patel et al.
Scalable, non-invasive tools are critically needed to improve early lung cancer detection and optimize primary care referral pathways. We evaluated Inflammacheck, a point-of-care device utilizing exhaled breath condensate (EBC) H2O2 and phy...
Formation of a Translational Science Professional Identity: A Heuristic Framework and Research Agenda [0.03%]
转化科学专业身份的形成：一种探究性框架和研究议程
Shannon L Casey,Whitney Sweeney,Lisa Cadmus-Bertram et al.
Shannon L Casey et al.
Based upon substantive professional engagement over two decades and the collective action of diverse professionals, this conceptual paper proposes that translational science (TS) is best understood as a meta-discipline. As with Science, Tec...
Tutorial on Analyzing Patient-Reported Outcome Measures in Clinical Development [0.03%]
临床开发中分析患者报告结果测量的教程
Krina Mehta,Jim H Hughes,Jiawei Zhou et al.
Krina Mehta et al.
Patient-reported outcomes (PROs) are now considered essential components of clinical development and regulatory assessment. Despite their widespread collection, PRO data remain under-utilized, with analyses often limited to descriptive summ...
A Simulation-Based Assessment of Dosage Regimen Appropriateness for Multiple Myeloma Medicines Reflecting Demographic and Ethnic Differences [0.03%]
基于模拟的多发性骨髓瘤药物治疗方案适当性评估反映人口和种族差异
Minji Kang,Suein Choi,Sung-Soo Park et al.
Minji Kang et al.
Bridging studies are often waived for orphan diseases such as multiple myeloma (MM) due to challenges in conducting clinical trials in small and heterogeneous populations. However, demographic and regional differences between trial particip...
Comparative Study
Clinical and translational science. 2026 Aug;19(8):e70664. DOI:10.1111/cts.70664 2026
Genetic Landscape of NAT2 in the Moroccan Population: Implications for Isoniazid Pharmacogenetics in Tuberculosis [0.03%]
摩洛哥人群NAT2基因多态性研究及其在结核病异烟肼个体化治疗中的意义
Nada Benyahya,Mohsine-Ali El-Hamri,Jaber Lyahyai et al.
Nada Benyahya et al.
The NAT2 gene encodes N-acetyltransferase 2, an enzyme critically involved in the biotransformation of numerous xenobiotics and aromatic amines, including isoniazid, a cornerstone drug in tuberculosis therapy. Genetic polymorphisms in NAT2 ...
Safety and Pharmacokinetics of Olamkicept Doses up to 2400 mg in Healthy Japanese Men: Phase I, Randomized, Placebo-Controlled, and Double-Blind Trial [0.03%]
一项关于奥拉克西普剂量达2400毫克在健康日本男性受试者中的安全性和药代动力学的I期、随机、双盲和安慰剂对照试验
Ryuzo Hanada,Katharina Bruzelius,Michael Falkenberg et al.
Ryuzo Hanada et al.
The first-in-class, fully human fusion protein, olamkicept, selectively inhibits trans interleukin-6 signaling. Previously, the safety, tolerability, pharmacokinetics (PK), and immunogenicity of olamkicept following single ascending doses (...
Clinical Trial
Clinical and translational science. 2026 Aug;19(8):e70673. DOI:10.1111/cts.70673 2026
Human Radiolabeled Mass Balance Studies Supporting New Drugs Approved by FDA Between 2019 and 2023 [0.03%]
2019—2023年FDA批准的含有放射性同位素药物的人体质量平衡研究综述
Anuradha Ramamoorthy,Alana Chen,Edwin Chiu Yuen Chow et al.
Anuradha Ramamoorthy et al.
Interleukin-40 in Systemic Sclerosis: A Treatment-Sensitive Marker of Immune Modulation Rather Than Disease Activity [0.03%]
系统性硬化症中的白细胞介素-40：一种免疫调节标志物而非疾病活性标志物
İbrahim Vasi,Emin Ümit Bağrıaçık,Rıza Can Kardaş et al.
İbrahim Vasi et al.
Interleukin-40 (IL-40) is a recently identified cytokine primarily produced by activated B cells and implicated in immune regulation across several autoimmune diseases. Although B cell-driven immune dysregulation plays a central role in sys...
Population Pharmacokinetics of Rituximab in Treatment-Naïve Chinese Patients With Diffuse Large B-cell Lymphoma During Induction Therapy: Clinical Implications [0.03%]
利妥昔单抗治疗中国初治弥漫大B细胞淋巴瘤患者的群体药代动力学：临床意义
Wan-Yi Zhou,Jing Ling,Meng-Meng Guan et al.
Wan-Yi Zhou et al.
This study aimed to establish and validate a population pharmacokinetic model for rituximab during induction therapy in treatment-naive patients with diffuse large B-cell lymphoma, identify covariates affecting key pharmacokinetic parameter...
Efficacy and Safety of Intracoronary Mesenchymal Stem Cell Administration in ST-Segment Elevation Acute Myocardial Infarction: A Meta-Analysis of Randomized Controlled Trials [0.03%]
随机对照试验中骨髓间充质干细胞治疗ST段抬高型急性心肌梗死的有效性和安全性 meta分析
Kaiming Chen,Shijie Zhao,Xiaoqian Zou et al.
Kaiming Chen et al.
ST-segment elevation myocardial infarction (STEMI) remains a major cause of cardiovascular mortality and morbidity worldwide. Despite advances in reperfusion therapy, many patients still develop irreversible myocardial injury and adverse ve...