Nicholas S Kowalczyk,Stuart M Sprague
Nicholas S Kowalczyk
Purpose: Renal bone disease has significant detrimental effects on both cardiovascular and bone health. It is important to understand that the pathophysiologic mechanisms are different from traditional causes of bone dise...
Obesity, insulin resistance and fertility: unresolved questions and emerging insights [0.03%]
肥胖，胰岛素抵抗和生育力：悬而未决的问题和新的见解
Kavita Narula,Julia S Kenkre,Wann Jia Loh et al.
Kavita Narula et al.
Purpose of review: Obesity significantly impacts fertility in women, contributing to hormonal imbalances, ovulatory dysfunction, and poor reproductive outcomes. This is especially pronounced in polycystic ovary syndrome (...
Steven K Malin
Steven K Malin
Purpose of review: Circadian biology influences the gastrointestinal system as exemplified by hormonal patterns that modulate appetite. Indeed, people tend to get hungrier towards the later parts of the day. How misalignm...
Targeting apolipoprotein C-III: a game changer for pancreatitis prevention in severe hypertriglyceridemia [0.03%]
针对载脂蛋白C-III的治疗：在严重高甘油三酯血症中预防胰腺炎的游戏规则改变者
Bram M Weijs,Reindert F Oostveen,Jordan M Kraaijenhof et al.
Bram M Weijs et al.
Purpose of review: The aim of this review is to examine recent advancements in RNA-targeted therapies for the management of severe hypertriglyceridemia (sHTG) and prevention of sHTG-associated acute pancreatitis. ...
Rosa Lu Yu,H Christian Weber
Rosa Lu Yu
Purpose of review: To provide an update of recent studies exploring the role of the gut microbiota and diet in the pathogenesis and treatment of irritable bowel syndrome (IBS). ...
Perspectives on early health economic evaluations of RNA therapies targeted at lipoprotein(a) [0.03%]
针对脂蛋白(a)的RNA疗法早期卫生经济学评估的观点
Angela Burvill,Gerald F Watts,Zanfina Ademi
Angela Burvill
Purpose of review: Early health economic evaluations of new medications are useful, as they consider the implications for health services.We reviewed recent literature on expected clinical outcomes of lowering of elevated...
An overview of persistent chylomicronemia: much more than meets the eye [0.03%]
持久性乳糜微粒血症概述——远不止所见的那样
Miriam Larouche,Gerald F Watts,Christie Ballantyne et al.
Miriam Larouche et al.
Purpose of review: The aim of this review is to provide an overview of severe hypertriglyceridemia presenting in the form of chylomicronemia that persists despite treatment of secondary causes and the use of conventional ...
Psychological determinants and evidence-based behavior change interventions in adherence to therapy for familial hypercholesterolemia [0.03%]
家族性高胆固醇血症治疗中的心理决定因素及基于证据的行为改变干预措施
Martin S Hagger,Kyra Hamilton
Martin S Hagger
Purpose of review: Patients with familial hypercholesterolemia have an elevated risk of premature atherosclerotic cardiovascular disease. Risks can be minimized through pharmacological and 'lifestyle' behavioral (low fat ...
Georgia Rigas,Shirley Alexander,Cilla J Haywood
Georgia Rigas
Purpose of review: Obesity is recognized as a "gateway" chronic, progressive disease of dysfunctional adipocytes. Glucagon-like peptide-1 receptor agonist-based therapies (GLP1BTs), including glucagon-like peptide-1 recep...