Hypertriglyceridemia: updates from clinical trials of new agents and real-world registries [0.03%]
高甘油三酯血症：新药临床试验和真实世界登记处的更新
Mohamed Haseef,Stephen C H Li,Tobias Gaitt et al.
Mohamed Haseef et al.
Purpose of review: Hypertriglyceridemia (HTG) is an independent risk factor for atherosclerotic cardiovascular disease (ASCVD) and acute pancreatitis (AP). Early detection and treatment are important to prevent such compl...
Jayanthi Ramanathan,David Sullivan,Gerald Watts et al.
Jayanthi Ramanathan et al.
Purpose of review: Familial hypercholesterolemia (FH) in pregnancy poses several challenges, requiring a delicate balance between maternal atherosclerotic cardiovascular disease (ASCVD) risk and foetal safety. The review ...
Beyond weight loss: tirzepatide as a dual GIP/GLP-1 receptor agonist for obstructive sleep apnea [0.03%]
减重之外：作为双效胃抑制多肽/胰高血糖素样肽-1受体激动剂治疗阻塞性睡眠呼吸暂停的 tirzepatide
Jairo A Noreña,Tugce Akcan,Dimpi Desai
Jairo A Noreña
Purpose of review: This review summarizes emerging evidence on the use of the dual glucose-dependent insulinotropic polypeptide (GIP)/glucagon-like peptide-1 (GLP-1) receptor agonist (RA) tirzepatide in improving obstruct...
Inhibition of angiopoietin-like protein 3 as a target for managing hypertriglyceridemia [0.03%]
靶向抑制血管生成素样蛋白3以治疗高甘油三酯血症
Pablo Corral,Natalia Nardelli,Laura Schreier
Pablo Corral
Purpose of review: To summarize recent advances in therapeutic strategies targeting angiopoietin-like protein 3 (ANGPTL3), a central regulator of triglyceride and remnant lipoprotein metabolism, and to discuss the potenti...
Stephen A Jiwanmall,Dheeraj Kattula
Stephen A Jiwanmall
Purpose of review: To highlight the recent advancements in understanding the influence of psychological factors on the causation and management of obesity, which holds significance for clinical practice. ...
Laura Briggs,Alexander Read,Sarah Darch et al.
Laura Briggs et al.
Purpose of review: Diabetes mellitus affects one in nine adults worldwide, with timely diagnosis and accurate classification being essential for patient management. C-peptide is an important biomarker in the diagnostic wo...
Can artificial intelligence and wearable technologies transform diabetes foot health? [0.03%]
人工智能和可穿戴技术能改变糖尿病足保健吗？
Wing May Kong,Farah Saif
Wing May Kong
Purpose of review: Diabetes foot ulcers (DFUs) affect millions globally, and are a global health challenge, contributing significantly to morbidity, mortality, and healthcare costs. This review article critically evaluate...
Sairabanu Mohamed Rashid Sokwalla,Swafiya Busaidy,Gautam Das
Sairabanu Mohamed Rashid Sokwalla
Purpose of review: Alongside its impact on cardio-metabolic parameters, obesity has been linked to infertility. This article aimed to provide a comprehensive review of the most current evidence linking male and female obe...
The role of the PPAR system in diabetic cardiovascular risk and beyond [0.03%]
PPAR系统在糖尿病心血管风险及其他方面的作用
Massimiliano Ruscica,Chiara Macchi,Alberto Corsini et al.
Massimiliano Ruscica et al.
Purpose of review: Peroxisome proliferator-activated receptors (PPARs) are transcription factors that regulate metabolic homeostasis and play a key role in the management of a number of metabolic disorders (e.g. diabetes ...
Lessons from recent clinical trials for the prevention of acute pancreatitis in chylomicronemia syndromes [0.03%]
近期脂蛋白脂酶缺乏和家族性高脂血病仓鼠糖尿病型综合征急性胰腺炎预防临床试验的教训
Laura D&#x;Erasmo,Daniele Tramontano,Marcello Arca
Laura D&#x;Erasmo
Purpose of review: Familial chylomicronemia (FCS) and multifactorial or persistent chylomicronemia syndromes (MCS, pCS) are rare, severe disorders characterized by extreme hypertriglyceridemia and a high risk of recurrent...