Identification of molecular subtypes of ischaemic stroke based on immune-related genes and weighted co-expression network analysis [0.03%]
基于免疫相关基因和加权共表达网络分析的缺血性卒中分子亚型的识别
Duncan Wei,Xiaopu Chen,Jing Xu et al.
Duncan Wei et al.
Immune system has been reported to play a key role in the development of ischaemic stroke (IS). Nevertheless, its exact immune-related mechanism has not yet been fully revealed. Gene expression data of IS and healthy control samples was dow...
Comprehensive analysis of LILR family genes expression and tumour-infiltrating immune cells in early-stage pancreatic ductal adenocarcinoma [0.03%]
胰腺导管腺癌早期LILR基因家族表达及肿瘤浸润性免疫细胞的综合分析
Qiang Gao,Shutian Mo,Chuangye Han et al.
Qiang Gao et al.
Leucocyte immunoglobulin-like receptors (LILRs) are closely related to tumourigenesis, but their clinical value in early-stage pancreatic ductal adenocarcinoma (PDAC) after pancreaticoduodenectomy remains unknown. Kaplan-Meier and Cox propo...
Development and validation of an immune-related gene signature for prognosis in Lung adenocarcinoma [0.03%]
一种用于预测肺腺癌预后的免疫相关基因标志物的构建与验证
Zehuai Guo,Xiangjun Qi,Zeyun Li et al.
Zehuai Guo et al.
The most common type of lung cancer tissue is lung adenocarcinoma. The TCGA-LUAD cohort retrieved from the TCGA dataset was considered the internal training cohort, while GSE68465 and GSE13213 datasets from the GEO database were used as the...
Comprehensive analysis of alternative splicing signatures in pancreatic head cancer [0.03%]
胰头癌替代剪接特征的综合分析
Lingshan Zhou,Yuan Yang,Jian Ma et al.
Lingshan Zhou et al.
The correlation between dysregulation of splicing and cancers has been increasingly recognised and confirmed. The identification of valuable alternative splicing (AS) in pancreatic head cancer (PHC) has a great significance. AS profiles in ...
The effect of normalisation and error model choice on the distribution of the maximum likelihood estimator for a biochemical reaction [0.03%]
正则化和误差模型选择对生化反应最大似然估计分布的影响
Caterina Thomaseth,Nicole E Radde
Caterina Thomaseth
Sparse and noisy measurements make parameter estimation for biochemical reaction networks difficult and might lead to ill-posed optimisation problems. This is potentiated if the data has to be normalised, and only fold changes rather than a...
Albert Doughan,Samson Pandam Salifu
Albert Doughan
Burkitt lymphoma (BL) is one of the most aggressive forms of non-Hodgkin's lymphomas that affect children and young adults. The expression of genes and other molecular markers during carcinogenesis can be the basis for diagnosis, prognosis ...
Design and implementation of an adaptive fuzzy sliding mode controller for drug delivery in treatment of vascular cancer tumours and its optimisation using genetic algorithm tool [0.03%]
基于遗传算法工具优化的自适应模糊滑模血管肿瘤药物传输控制系统设计与实现
Ehsan Sadeghi Ghasemabad,Iman Zamani,Hami Tourajizadeh et al.
Ehsan Sadeghi Ghasemabad et al.
In this paper, the side effects of drug therapy in the process of cancer treatment are reduced by designing two optimal non-linear controllers. The related gains of the designed controllers are optimised using genetic algorithm and simultan...
Identifying driver modules based on multi-omics biological networks in prostate cancer [0.03%]
基于前列腺癌多组学生物网络的驱动模块识别
Zhongli Chen,Biting Liang,Yingfu Wu et al.
Zhongli Chen et al.
The development of sequencing technology has promoted the expansion of cancer genome data. It is necessary to identify the pathogenesis of cancer at the molecular level and explore reliable treatment methods and precise drug targets in canc...
CHAC1 as a novel biomarker for distinguishing alopecia from other dermatological diseases and determining its severity [0.03%]
CHAC1作为区分斑秃与其他皮肤病以及确定其严重程度的新生物标志物
Hassan Karami,Samira Nomiri,Mohammad Ghasemigol et al.
Hassan Karami et al.
Alopecia Areata (AA) is characterised by an autoimmune response to hair follicles (HFs) and its exact pathobiology remains unclear. The current study aims to look into the molecular changes in the skin of AA patients as well as the potentia...