CFCPred: Advancing circRNAs-Encoded Peptides Prediction Through Cluster Purity-Guided Resampling and Fuzzy Voting [0.03%]
通过聚类纯度引导的重采样和模糊投票推进圆环RNA编码肽预测
Siyuan Zhao,Bin Yu,Lingling Liu
Siyuan Zhao
Circular RNAs (circRNAs) have recently been shown to possess coding potential via a cap-independent translation mechanism, challenging their traditional classification as noncoding RNAs and implicating it directly in the pathogenesis of var...
Double Q-Learning for Intelligent Multi-Drug Scheduling in Cancer Chemotherapy Optimisation [0.03%]
用于癌症化疗优化的智能多药调度的双Q学习方法
Behnoush Alizade,Ahmad Hajipour
Behnoush Alizade
Chemotherapy scheduling poses a challenging control problem due to the need to suppress tumour growth whilst maintaining systemic toxicity within clinically acceptable limits. This study develops a double Q-learning-based controller for opt...
Machine Learning Modelling, Single-Cell Landscape Profiling and Spatial Transcriptomics Provide New Insights Into SUMOylation in Head and Neck Squamous Cell Carcinoma [0.03%]
机器学习建模、单细胞景观分析和空间转录组学为头颈鳞状细胞癌中的SUMO化研究提供新见解
Zhe Fang,Kai Mei,Jiaqi Liu et al.
Zhe Fang et al.
SUMOylation is implicated in the regulation of multiple malignancies. However, its potential roles in head and neck squamous cell carcinoma (HNSCC) remain insufficiently characterised. By integrating bulk RNA-seq, scRNA-seq and stRNA-seq da...
Exposure the Hazardous Potential of Quinalphos: An In-Depth Analysis for Environmental and Biological Effects on Human Health [0.03%]
喹氧磷的有害潜力：环境和生物学效应及其对人类健康影响的深入分析
Jyoti Kant Choudhari,Biju Prava Sahariah,Anand Kumar Jayapal et al.
Jyoti Kant Choudhari et al.
Quinalphos pesticide (QP) exposure can lead to various human health effects, including anaemia, leucocytosis with neutrophilia, hepatic damage and oxidative stress. Acute poisoning symptoms include weakness, sweating, impaired vision and ne...
A Potential miR-1246-5p-H3K27ac-NOL12 Regulatory Axis and Its Putative Tumour-Promoting Function in Hepatocellular Carcinoma [0.03%]
肝细胞癌中潜在的miR-1246-5p-H3K27ac-NOL12调控轴及其可能的促肿瘤功能
Li Xiao,Yu-Long Deng,Li-Na Liang et al.
Li Xiao et al.
Hepatocellular carcinoma (HCC) is a major cause of cancer-related death worldwide. Although the nucleolar protein NOL12 has been implicated in HCC progression, its comprehensive expression patterns, clinical significance and regulation-part...
Identification of Mitochondria- and Macrophage Activation-Related Hub Genes in Sarcopenia [0.03%]
肌减少症中与线粒体和巨噬细胞活化相关的关键基因的鉴定
Bangzhi Li,Long Shi,Qiong Wang et al.
Bangzhi Li et al.
To explore the hub genes and pathways associated with sarcopenia progression from the perspective of mitochondrial dysfunction and macrophage activation. The GEO datasets GSE8479, GSE1428 and GSE136344 were obtained from the GEO database. M...
Identification of MTFR1 as a Novel Prognostic Biomarker and Putative Oncogene for Breast Cancer: A Multi-Omics Analysis and in Vitro Experimental Validation [0.03%]
多组学分析及体内实验证实MTFR1可作为乳腺癌新型预后生物标志物及潜在的致癌基因
Ya Liu,Xiaofan Yuan,Hong Chen
Ya Liu
Mitochondrial Fission Regulator 1 (MTFR1) plays a critical regulatory role in various malignancies; however, its specific function and clinical significance in breast cancer (BRCA) remain unexplored. This study systematically characterised ...
scGMB: A scRNA-seq Cell Classification Method Combining GCN and Mamba [0.03%]
结合GCN和MAMBA的scRNA-seq细胞分类方法-scGMB
Lejun Gong,Like Yu,Yimu Ji et al.
Lejun Gong et al.
This study proposes a single-cell RNA sequencing data classification method called scGMB, which is based on graph convolutional networks (GCN) and the Mamba model. This method constructs a cell graph to capture the topological relationships...
Identification of Chemokine-Related Genes Derived From T and NK Cells in the Tumour Microenvironment of Ovarian Cancer Based on scRNA-Seq [0.03%]
基于scRNA-seq的卵巢癌肿瘤微环境中T/NK细胞来源的相关细胞因子基因鉴定
Liang Wang,Guifen Liu,Liying Wang et al.
Liang Wang et al.
Ovarian cancer (OC) is characterised by high malignancy. Tumour immune microenvironment (TME) may serve as a breakthrough for therapy. Chemokines are responsible for the recruitment of diverse immune cells in TME. We identify the associatio...
Unravelling the Mechanism of Compound Kushen Injection in Treating Cervical Cancer Through Ferroptosis Regulation: An Integrated Network Pharmacology and Molecular Docking Study [0.03%]
基于网络药理学和分子对接的复方苦参注射液治疗宫颈癌的研究及其铁死亡调控机制解析
Linlin Chen,Chunmei Li,Cheng Xu et al.
Linlin Chen et al.
This study employed network pharmacology and molecular docking techniques to investigate the potential mechanisms of Compound Ku Shen Injection in the treatment of cervical cancer (CC), focussing on ferroptosis. Active compounds and corresp...