Identification of MTFR1 as a Novel Prognostic Biomarker and Putative Oncogene for Breast Cancer: A Multi-Omics Analysis and in Vitro Experimental Validation [0.03%]
多组学分析及体内实验证实MTFR1可作为乳腺癌新型预后生物标志物及潜在的致癌基因
Ya Liu,Xiaofan Yuan,Hong Chen
Ya Liu
Mitochondrial Fission Regulator 1 (MTFR1) plays a critical regulatory role in various malignancies; however, its specific function and clinical significance in breast cancer (BRCA) remain unexplored. This study systematically characterised ...
scGMB: A scRNA-seq Cell Classification Method Combining GCN and Mamba [0.03%]
结合GCN和MAMBA的scRNA-seq细胞分类方法-scGMB
Lejun Gong,Like Yu,Yimu Ji et al.
Lejun Gong et al.
This study proposes a single-cell RNA sequencing data classification method called scGMB, which is based on graph convolutional networks (GCN) and the Mamba model. This method constructs a cell graph to capture the topological relationships...
Identification of Chemokine-Related Genes Derived From T and NK Cells in the Tumour Microenvironment of Ovarian Cancer Based on scRNA-Seq [0.03%]
基于scRNA-seq的卵巢癌肿瘤微环境中T/NK细胞来源的相关细胞因子基因鉴定
Liang Wang,Guifen Liu,Liying Wang et al.
Liang Wang et al.
Ovarian cancer (OC) is characterised by high malignancy. Tumour immune microenvironment (TME) may serve as a breakthrough for therapy. Chemokines are responsible for the recruitment of diverse immune cells in TME. We identify the associatio...
Unravelling the Mechanism of Compound Kushen Injection in Treating Cervical Cancer Through Ferroptosis Regulation: An Integrated Network Pharmacology and Molecular Docking Study [0.03%]
基于网络药理学和分子对接的复方苦参注射液治疗宫颈癌的研究及其铁死亡调控机制解析
Linlin Chen,Chunmei Li,Cheng Xu et al.
Linlin Chen et al.
This study employed network pharmacology and molecular docking techniques to investigate the potential mechanisms of Compound Ku Shen Injection in the treatment of cervical cancer (CC), focussing on ferroptosis. Active compounds and corresp...
Metabolic Reprogramming in Recurrent Spontaneous Abortion: Key Biomarkers Identification and Diagnostic Model Development [0.03%]
复发性流产的代谢重构：关键生物标志物识别及诊断模型构建
Fan Wu,Chuanmei Qin,Xiaowei Wei et al.
Fan Wu et al.
Recurrent spontaneous abortion (RSA) involves complex and often unexplained pathogenesis. This study investigated metabolic reprogramming in RSA to identify diagnostic biomarkers. We integrated GEO datasets (GSE26787, GSE165004), identified...
Network Pharmacology and Experimental Validation to Explore the Potential Mechanism of Salvianolic Acid B in Reversing Oxaliplatin Resistance of Colorectal Cancer Cells [0.03%]
网络药理学与实验验证探讨丹参素B逆转奥沙利铂耐药的机制
Wei Liang,Bo Li,Huan Yang et al.
Wei Liang et al.
Chemotherapy resistance of colorectal cancer (CRC) seriously affects the therapeutic effect. Salvianolic acid B (SalB) is a primary active compound found in the traditional Chinese medicine (TCM) Danshen, known for its antitumour properties...
Integrated Analysis Identifies an Anoikis-Related Gene Signature for Predicting Prognosis in Patients With Triple-Negative Breast Cancer [0.03%]
整合分析确定了一个与预后有关的转移性乳腺癌凋亡相关的基因标志物
Bing Xue,Yue Bai,Wu-Di Yang et al.
Bing Xue et al.
Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with limited therapeutic options and poor prognosis. Anoikis resistance contributes to tumour dissemination, metastasis and therapeutic resistance. However, anoikis...
Functionalist Oncology to Model the Contextuality of Dynamics and Treatment in Acute Myeloid Leukaemia [0.03%]
功能主义肿瘤学：构建急性髓系白血病动态和治疗情境模型
Alexander Ehmann,Rakan Naboulsi,Martin Jädersten et al.
Alexander Ehmann et al.
Acute myeloid leukaemia (AML) is a disease with high intra- and interpatient heterogeneity. Current treatments are still based on cytarabine combined with an anthracycline, with 5-year overall survival rates below 30%. Functionalist oncolog...
Fractional Order Total Variation Low-Rank Representation on Single-Cell RNA Sequencing Clustering [0.03%]
基于单细胞RNA测序聚类的分数阶总变差低秩表示方法
Pengcheng Yang,Fei Lu,Qianwen Xue et al.
Pengcheng Yang et al.
Traditional bulk RNA sequencing often masks cell-to-cell variability, leading to a loss of individual heterogeneity information. Single-cell RNA sequencing (scRNA-seq) preserves cellular heterogeneity by reverse-transcribing, amplifying, as...
Data-Driven Identification of Rational Nonlinear Dynamics in Biochemical Networks via an Implicit Singular Value Decomposition Based Framework [0.03%]
基于隐式奇异值分解框架的生化网络理性非线性动力学的数据驱动识别方法
Hongtao Zhu,Longwei Zuo,Chunjian Pan et al.
Hongtao Zhu et al.
Using rational functions to describe the dynamics of the biological network is common in the field of biology. Estimating such dynamics from data is challenging owing to the complex nonlinearities. Although sparse identification of nonlinea...