Identification of toll-like receptor 5 and acyl-CoA synthetase long chain family member 1 as hub genes are correlated with the severe forms of COVID-19 by Weighted gene co-expression network analysis [0.03%]
通过加权基因共表达网络分析鉴定Toll样受体5和长链酰基辅酶A合成酶家族成员1作为与COVID-19严重形式相关的中心基因
Luoyi Wang,Zhaomin Mao,Fengmin Shao
Luoyi Wang
Since a 25% mortality rate occurred in critical Coronavirus disease 2019 (COVID-19) patients, investigating the potential drivers remains to be important. Here, the authors applied Weighted Gene Co-expression Network Analysis to identify th...
Bioinformatics approach to identify the hub gene associated with COVID-19 and idiopathic pulmonary fibrosis [0.03%]
生物信息学方法识别与COVID-19和特发性肺纤维化相关的中心基因
Wenchao Shi,Tinghui Li,Huiwen Li et al.
Wenchao Shi et al.
The coronavirus disease 2019 (COVID-19) has developed into a global health crisis. Pulmonary fibrosis, as one of the complications of SARS-CoV-2 infection, deserves attention. As COVID-19 is a new clinical entity that is constantly evolving...
Mohamadreza Homayounzade,Maryam Homayounzadeh,Mohammad Hassan Khooban
Mohamadreza Homayounzade
In practice, many physical systems, including physiological ones, can be considered whose input can take only positive quantities. However, most of the conventional control methods do not support the positivity of the main input data to the...
Identification of basement membrane markers in diabetic kidney disease and immune infiltration by using bioinformatics analysis and experimental verification [0.03%]
基于生物信息学分析和实验验证的糖尿病肾脏疾病基底膜标志物及免疫浸润特征识别研究
Rui Shi,Wen-Man Zhao,Li Zhu et al.
Rui Shi et al.
Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease worldwide. Basement membranes (BMs) are ubiquitous extracellular matrices which are affected in many diseases including DKD. Here, the authors aimed to identify BM...
An immune-related multi-omics analysis of dolichyl-diphosphooligosaccharide protein glycosyltransferase in glioma: Prognostic value exploration and competitive endogenous RNA network identification [0.03%]
长萜醇二磷酸寡糖蛋白甘露糖转移酶在胶质瘤中的免疫相关多组学分析：预后价值探索和竞争性内源RNA网络识别
Jie Liu,Chao Feng,Min Liu et al.
Jie Liu et al.
Dolichyl-diphosphooligosaccharide protein glycosyltransferase (DDOST) plays a pivotal role in the glycosylation of asparagine residues on nascent polypeptides. However, the biological role of DDOST in glioma remains unclear. The mRNA expres...
Single-cell RNA sequencing identifies macrophage signatures correlated with clinical features and tumour microenvironment in meningiomas [0.03%]
单细胞RNA测序识别出与脑膜瘤临床特征和肿瘤微环境相关的巨噬细胞标志物
Xiaowei Zhang
Xiaowei Zhang
Background: Meningiomas are common primary brain tumours, with macrophages playing a crucial role in their development and progression. This study aims to identify module genes correlated with meningioma-associated macrop...
High expression of centromere protein A and its molecular mechanism and clinical significance in prostate cancer: A study based on data mining and immunohistochemistry [0.03%]
前列腺癌中中心体蛋白A高表达及其分子机制和临床意义：基于数据挖掘与免疫组化的一站式研究
Fang-Cheng Jiang,Gao-Qiang Zhai,Jia-Lin Liu et al.
Fang-Cheng Jiang et al.
The progression of prostate cancer (PCa) leads to poor prognosis. However, the molecular mechanism of PCa is still not completely clear. This study aimed to elucidate the important role of centromere protein A (CENPA) in PCa. Large numbers ...
Deep sequencing of circulating miRNAs and target mRNAs level in deep venous thrombosis patients [0.03%]
深静脉血栓患者循环miRNA及靶mRNA的高通量测序分析
Qingxian Wang,Yunhe Chang,Xuqing Yang et al.
Qingxian Wang et al.
Deep venous thrombosis is one of the most common peripheral vascular diseases that lead to major morbidity and mortality. The authors aimed to identify potential differentially expressed miRNAs and target mRNAs, which were helpful in unders...
A novel investigation into an E2F transcription factor-related prognostic model with seven signatures for colon cancer patients [0.03%]
一项关于E2F转录因子相关标志物的结直肠癌预后模型的最新研究
Xiaoyong Shen,Zheng Su,Yan Dou et al.
Xiaoyong Shen et al.
The pathogenesis of colon cancer, a common gastrointestinal tumour, involves complicated factors, especially a series of cell cycle-related genes. E2F transcription factors during the cell cycle play an essential role in the occurrence of c...
Single-cell RNA-seq and bulk RNA-seq explore the prognostic value of exhausted T cells in hepatocellular carcinoma [0.03%]
单细胞RNA测序和bulk RNA测序探索肝癌中耗竭T细胞的预后价值
Xiaolong Tang,Yandong Miao,Lixia Yang et al.
Xiaolong Tang et al.
Hepatocellular carcinoma (HCC) remains a worldwide health problem. Mounting evidence indicates that exhausted T cells play a critical role in the progress and treatment of HCC. Therefore, a detailed characterisation of exhausted T cells and...