Integrated bioinformatics analysis identified leucine rich repeat containing 15 and secreted phosphoprotein 1 as hub genes for calcific aortic valve disease and osteoarthritis [0.03%]
整合生物信息学分析确定富含亮氨酸的重复序列基因15和分泌型丝氨酸蛋白酶抑制剂1是主动脉瓣钙化和骨关节炎的关键基因
Shuji Gong,Kun Xiang,Le Chen et al.
Shuji Gong et al.
Calcific aortic valve disease (CAVD) and osteoarthritis (OA) are common diseases in the ageing population and share similar pathogenesis, especially in inflammation. This study aims to discover potential diagnostic and therapeutic targets i...
Excavation of gene markers associated with pancreatic ductal adenocarcinoma based on interrelationships of gene expression [0.03%]
基于基因表达互作关系的胰腺导管腺癌相关基因标记物挖掘
Zhao-Yue Zhang,Zi-Jie Sun,Dong Gao et al.
Zhao-Yue Zhang et al.
Pancreatic ductal adenocarcinoma (PDAC) accounts for 95% of all pancreatic cancer cases, posing grave challenges to its diagnosis and treatment. Timely diagnosis is pivotal for improving patient survival, necessitating the discovery of prec...
Analysis of disulfidptosis- and cuproptosis-related LncRNAs in modulating the immune microenvironment and chemosensitivity in colon adenocarcinoma [0.03%]
结肠腺癌中调控免疫微环境和化疗敏感性的含二硫键蛋白介导的凋亡和铜介导的凋亡相关LncRNAs分析
Qiang Fan,Guang-Bo Wu,Min Chen et al.
Qiang Fan et al.
The main objective was to establish a prognostic model utilising long non-coding RNAs associated with disulfidptosis and cuproptosis. The data for RNA-Sequence and clinicopathological information of Colon adenocarcinoma (COAD) were acquired...
Anoikis-related genes as potential prognostic biomarkers in gastric cancer: A multilevel integrative analysis and predictive therapeutic value [0.03%]
anoikis相关基因作为胃癌潜在预后生物标志物的多水平整合分析和预测治疗价值
Yongjian Lin,Jinlu Liu
Yongjian Lin
Background: Gastric cancer (GC) is a frequent malignancy of the gastrointestinal tract. Exploring the potential anoikis mechanisms and pathways might facilitate GC research. ...
The 'Other' subfamily of HECT E3 ubiquitin ligases evaluate the tumour immune microenvironment and prognosis in patients with hepatocellular carcinoma [0.03%]
HECT E3泛素连接酶的“其他”亚家族评估肝细胞癌患者肿瘤免疫微环境和预后
Runyu Dong,Zhixiong Wang,Danping Cao et al.
Runyu Dong et al.
Primary liver cancer is the sixth most common cancer and the third leading cause of cancer-related death worldwide. The role of the 'Other' subfamily of HECT E3 ligases (E3s) in hepatocellular carcinoma (HCC) remains unknown. The expression...
Machine learning unveils RNA polymerase II binding as a predictor for SMAD2-dependent transcription dynamics in response to Actvin signalling [0.03%]
机器学习揭示了RNA聚合酶II的结合可作为响应Activin信号转导时SMAD2依赖性转录动力学的预测指标
Dan Shi,Weihua Feng,Zhike Zi
Dan Shi
The transforming growth factor-β (TGF-β) superfamily, including Nodal and Activin, plays a critical role in various cellular processes. Understanding the intricate regulation and gene expression dynamics of TGF-β signalling is of interes...
Research on symptoms composition, time series evolution, and network visualisation of interstitial cystitis based on complex network community discovery algorithm [0.03%]
基于复杂网络社区发现算法的间质性膀胱炎的症状组成、时间序列演化及网络可视化研究
Lei Pang,Zijun Ding,Xiaodong Bian et al.
Lei Pang et al.
We analyzed the symptoms composition of Interstitial Cystitis (IC), the regularity of the evolution of symptoms before and after treatment, and the visualization of the community network, to provide a reference for clinical diagnosis and tr...
Kinetic modelling of β-cell metabolism reveals control points in the insulin-regulating pyruvate cycling pathways [0.03%]
β细胞代谢的kinetic模型揭示了调节胰岛素的丙酮酸循环途径的控制点
Rahul Rahul,Adam R Stinchcombe,Jamie W Joseph et al.
Rahul Rahul et al.
Insulin, a key hormone in the regulation of glucose homoeostasis, is secreted by pancreatic β-cells in response to elevated glucose levels. Insulin is released in a biphasic manner in response to glucose metabolism in β-cells. The first p...
Bioinformatics identification of a T-cell-related signature for predicting prognosis and drug sensitivity in hepatocellular carcinoma [0.03%]
生物信息学鉴定与肝细胞癌预后和药物敏感性相关的T细胞特征签名
Dianqian Wang,Dongxiao Ding,Junjie Ying et al.
Dianqian Wang et al.
Hepatocellular carcinoma (HCC) is a fatal disease with poor clinical outcomes. T cells play a vital role in the crosstalk between the tumour microenvironment and HCC. Single-cell RNA sequencing data were downloaded from the GSE149614 datase...
Prediction and analysis of genetic effect in idiopathic pulmonary fibrosis and gastroesophageal reflux disease [0.03%]
特发性肺纤维化和胃食管反流病的遗传效应预测及分析
Peipei Chen,Lubin Xie,Leikai Ma et al.
Peipei Chen et al.
With increasing research on idiopathic pulmonary fibrosis (IPF) and gastroesophageal reflux disease (GERD), more and more studies have indicated that GERD is associated with IPF, but the underlying pathological mechanisms remain unclear. Th...