The mechanism of arsenic trioxide and microwave ablation in the treatment of oral squamous cell carcinoma based on high throughput sequencing [0.03%]
基于高通量测序的三氧化二砷与微波消融治疗口腔鳞癌的机制研究
Xuesong Zhang,Yakun Liu,Shengteng He et al.
Xuesong Zhang et al.
Oral squamous cell carcinoma (OSCC) is a common head and neck malignant tumour with high incidence and poor prognosis. Arsenic trioxide (ATO) has therapeutic effects on solid tumours. Microwave ablation (MWA) has unique advantages in the tr...
Transcriptomic analysis reveals pathways underlying the multi-antibiotic resistance of Klebsiella pneumoniae [0.03%]
转录组分析揭示了肺炎克雷伯菌多重抗生素抗药性的作用机制
Ying Liu,Zhihui Niu,Rile Wu et al.
Ying Liu et al.
Klebsiella pneumoniae, an opportunistic pathogen, is pervasively distributed across the world. Its escalating antibiotic resistance poses a serious threat to global public health. The mechanisms behind this resistance remain largely elusive...
Analysis of type 2 diabetes mellitus-related genes by constructing the pathway-based weighted network [0.03%]
基于通路的加权网络构建分析2型糖尿病相关基因
Xue-Yan Zhang,Chuan-Yun Xu,Ke-Fei Cao et al.
Xue-Yan Zhang et al.
Complex network is an effective approach to studying complex diseases, and provides another perspective for understanding their pathological mechanisms by illustrating the interactions between various factors of diseases. Type 2 diabetes me...
Identification of CCR7 and CBX6 as key biomarkers in abdominal aortic aneurysm: Insights from multi-omics data and machine learning analysis [0.03%]
基于组学数据和机器学习分析识别腹主动脉瘤关键生物标志物CCR7和CBX6及其作用机制研究
Xi Yong,Xuerui Hu,Tengyao Kang et al.
Xi Yong et al.
Abdominal aortic aneurysm (AAA) is a severe vascular condition, marked by the progressive dilation of the abdominal aorta, leading to rupture if untreated. The objective of this study was to identify key biomarkers and decipher the immune m...
Identification of co-localised transcription factors based on paired motifs analysis [0.03%]
基于配对基序分析的共定位转录因子识别方法
Li Liu,Lu Han,Kaiyuan Han et al.
Li Liu et al.
The interaction of transcription factors (TFs) with DNA precisely regulates gene transcription. In mammalian cells, thousands of TFs often interact with DNA cis-regulatory elements in a combinatorial manner rather than act alone. The identi...
DDANet: A deep dilated attention network for intracerebral haemorrhage segmentation [0.03%]
DDANet：一种深度膨胀注意力网络用于脑内出血的分割
Haiyan Liu,Yu Zeng,Hao Li et al.
Haiyan Liu et al.
Intracranial haemorrhage (ICH) is an urgent and potentially fatal medical condition caused by brain blood vessel rupture, leading to blood accumulation in the brain tissue. Due to the pressure and damage it causes to brain tissue, ICH resul...
Inference and analysis of cell-cell communication of non-myeloid circulating cells in late sepsis based on single-cell RNA-seq [0.03%]
基于单细胞RNA测序的晚期脓毒症非髓系循环细胞间通讯的推理与分析
Yanyan Tao,Miaomiao Li,Cheng Liu
Yanyan Tao
Sepsis is a severe systemic inflammatory syndrome triggered by infection and is a leading cause of morbidity and mortality in intensive care units (ICUs). Immune dysfunction is a hallmark of sepsis. In this study, the authors investigated c...
Human essential gene identification based on feature fusion and feature screening [0.03%]
基于特征融合和特征筛选的人类功能基因识别方法研究
Zhao-Yue Zhang,Yue-Er Fan,Cheng-Bing Huang et al.
Zhao-Yue Zhang et al.
Essential genes are necessary to sustain the life of a species under adequate nutritional conditions. These genes have attracted significant attention for their potential as drug targets, especially in developing broad-spectrum antibacteria...
siRNAEfficacyDB: An experimentally supported small interfering RNA efficacy database [0.03%]
siRNA效用数据库：小干扰rna效力实验支持的数据库
Yang Zhang,Ting Yang,Yu Yang et al.
Yang Zhang et al.
Small interfering RNA (siRNA) has revolutionised biomedical research and drug development through precise post-transcriptional gene silencing technology. Despite its immense potential, siRNA therapy still faces technical challenges, such as...
Deep-GB: A novel deep learning model for globular protein prediction using CNN-BiLSTM architecture and enhanced PSSM with trisection strategy [0.03%]
基于CNN-BiLSTM架构和三区策略的深度学习蛋白质预测模型
Sonia Zouari,Farman Ali,Atef Masmoudi et al.
Sonia Zouari et al.
Globular proteins (GPs) play vital roles in a wide range of biological processes, encompassing enzymatic catalysis and immune responses. Enzymes, among these globular proteins, facilitate biochemical reactions, while others, such as haemogl...