PPDAMEGCN: Predicting piRNA-Disease Associations Based on Multi-Edge Type Graph Convolutional Network [0.03%]
基于多边类型图卷积网络的piRNA疾病关联预测方法研究
Yinglong Peng,Shuang Chu,Xindi Huang et al.
Yinglong Peng et al.
Recently, many studies have proven that Piwi-interacting RNAs (piRNAs) play key roles in various biological processes and also associate with human complicated diseases. Therefore, in order to accelerate the traditional biomedical experimen...
ACP-DPE: A Dual-Channel Deep Learning Model for Anticancer Peptide Prediction [0.03%]
ACP-DPE：一种用于抗癌肽预测的双通道深度学习模型
Guohua Huang,Yujie Cao,Qi Dai et al.
Guohua Huang et al.
Cancer is a serious and complex disease caused by uncontrolled cell growth and is becoming one of the leading causes of death worldwide. Anticancer peptides (ACPs), as a bioactive peptide with lower toxicity, emerge as a promising means of ...
PADG-Pred: Exploring Ensemble Approaches for Identifying Parkinson's Disease Associated Biomarkers Using Genomic Sequences Analysis [0.03%]
PADG-Pred：利用基因组序列分析探索帕金森病相关生物标志物的集成方法
Ayesha Karim,Tamim Alkhalifah,Fahad Alturise et al.
Ayesha Karim et al.
Parkinson's disease (PD), a degenerative disorder affecting the nervous system, manifests as unbalanced movements, stiffness, tremors, and coordination difficulties. Its cause, believed to involve genetic and environmental factors, undersco...
Transcriptome sequencing and metabolome analysis to reveal renewal evidence for drought adaptation in mulberry [0.03%]
转录组测序和代谢组分析揭示桑树干旱适应性更新证据
Dan Liu,Changyu Qiu,Sheng Huang et al.
Dan Liu et al.
As an economically important tree species, mulberry (Morus spp.) has exhibited a remarkable tolerance for salinity, drought and heavy metals. However, the precise mechanism of metabolome-mediated drought adaptation is unclear. In this study...
SeqBMC: Single-cell data processing using iterative block matrix completion algorithm based on matrix factorisation [0.03%]
基于矩阵分解的迭代分块矩阵补全算法的单细胞数据处理（SeqBMC）
Gong Lejun,Yu Like,Wei Xinyi et al.
Gong Lejun et al.
With the development of high-throughput sequencing technology, the analysis of single-cell RNA sequencing data has become the focus of current research. Matrix analysis and processing of downstream gene expression after preprocessing is a h...
StackAHTPs: An explainable antihypertensive peptides identifier based on heterogeneous features and stacked learning approach [0.03%]
基于异构特征和堆叠学习的可解释性降压肽识别模型
Ali Ghulam,Muhammad Arif,Ahsanullah Unar et al.
Ali Ghulam et al.
Hypertension, often known as high blood pressure, is a major concern to millions of individuals globally. Recent studies have demonstrated the significant efficacy of naturally derived peptides in reducing blood pressure. Hypertension is on...
The optimised model of predicting protein-metal ion ligand binding residues [0.03%]
一种优化的预测蛋白质金属结合残基的方法模型
Caiyun Yang,Xiuzhen Hu,Zhenxing Feng et al.
Caiyun Yang et al.
Metal ions are significant ligands that bind to proteins and play crucial roles in cell metabolism, material transport, and signal transduction. Predicting the protein-metal ion ligand binding residues (PMILBRs) accurately is a challenging ...
SpaGraphCCI: Spatial cell-cell communication inference through GAT-based co-convolutional feature integration [0.03%]
基于GAT的协同卷积特征集成的细胞间通信推理（SpaGraphCCI）
Han Zhang,Ting Cui,Xiaoqiang Xu et al.
Han Zhang et al.
Spatially resolved transcriptomics technologies potentially provide the extra spatial position information and tissue image to better infer spatial cell-cell interactions (CCIs) in processes such as tissue homeostasis, development, and dise...
Emergent robust oscillatory dynamics in the interlocked feedback-feedforward loops [0.03%]
相互交织的反馈-前馈回路中的突发鲁棒振荡动力学现象
Guturu L Harika,Krishnamachari Sriram
Guturu L Harika
One of the challenges that beset modelling complex biological networks is to relate networks to function to dynamics. A further challenge is deciphering the cellular function and dynamics that can change drastically when the network edge is...
Microbiome analysis reveals the potential mechanism of herbal sitz bath complementary therapy in accelerating postoperative recovery from perianal abscesses [0.03%]
微生物组分析揭示了中药坐浴辅助治疗加速肛周脓肿术后恢复的潜在机制
Xinghua Chen,Xiutian Guo
Xinghua Chen
The herbal sitz bath formula, as a complementary therapy, effectively alleviates postoperative wound pain and accelerates healing time in patients with perianal abscesses. To investigate its mechanism of action, this study conducted 16S rRN...
Randomized Controlled Trial
IET systems biology. 2025 Jan-Dec;19(1):e12114. DOI:10.1049/syb2.12114 2025