Disjoint motif discovery in biological network using pattern join method [0.03%]
基于模式连接的方法在生物网络中发现离散的motif
Sabyasachi Patra,Anjali Mohapatra
Sabyasachi Patra
The biological network plays a key role in protein function annotation, protein superfamily classification, disease diagnosis, etc. These networks exhibit global properties like small-world property, power-law degree distribution, hierarchi...
Muhammad Rizwan Azam,Vadim I Utkin,Ali Arshad Uppal et al.
Muhammad Rizwan Azam et al.
A significant loss of p53 protein, an anti-tumour agent, is observed in early cancerous cells. Induction of small molecules based drug is by far the most prominent technique to revive and maintain wild-type p53 to the desired level. In this...
Mining conditions specific hub genes from RNA-Seq gene-expression data via biclustering and their application to drug discovery [0.03%]
基于双聚类的RNA测序基因表达数据中的条件特异性中枢基因挖掘及其在药物发现中的应用
Ankush Maind,Shital Raut
Ankush Maind
Gene-expression data is being widely used for various clinical research. It represents expression levels of thousands of genes across the various experimental conditions simultaneously. Mining conditions specific hub genes from gene-express...
Yi Ding,Wen-June Wang
Yi Ding
Currently, the anti-viral therapy has been extensively utilised to reduce the viral burden and switch off certain infectious sources for hepatitis B virus (HBV) infected patients in clinical treatment. Several pieces of existing evidence ha...
Contribution of time delays to p53 oscillation in DNA damage response [0.03%]
时间延迟在DNA损伤反应中诱导p53振荡的贡献研究
Conghua Wang,Haihong Liu,Jin Zhou
Conghua Wang
Although the oscillatory dynamics of the p53 network have been extensively studied, the understanding of the mechanism of delay-induced oscillations is still limited. In this paper, a comprehensive mathematical model of p53 network is studi...
Identification of a time-varying intracellular signalling model through data clustering and parameter selection: application to NF-[inline-formula removed]B signalling pathway induced by LPS in the presence of BFA [0.03%]
基于数据聚类和参数选择的时变细胞内信号转导模型识别：LPS诱导的BFA存在下NF-κB信号转导途径的应用
Dongheon Lee,Arul Jayaraman,Joseph Sang-Il Kwon
Dongheon Lee
Developing a model for a signalling pathway requires several iterations of experimentation and model refinement to obtain an accurate model. However, the implementation of such an approach to model a signalling pathway induced by a poorly-k...
Hilbert transform-based time-series analysis of the circadian gene regulatory network [0.03%]
基于希尔伯特变换的昼夜基因调控网络时间序列分析
Shiju S,K Sriram
Shiju S
In this work, the authors propose the Hilbert transform (HT)-based numerical method to analyse the time series of the circadian rhythms. They demonstrate the application of HT by taking both deterministic and stochastic time series that the...
Activity assessment of small drug molecules in estrogen receptor using multilevel prediction model [0.03%]
利用多水平预测模型评估小分子药物在雌激素受体中的活性
Vishan Kumar Gupta,Prashant Singh Rana
Vishan Kumar Gupta
The authors have proposed an efficient multilevel prediction model for better activity assessment to test whether certain chemical compounds can disrupt processes in the human body that may create negative health effects. Here, a computatio...
Robust multi-objective blood glucose control in Type-1 diabetic patient [0.03%]
I型糖尿病患者的鲁棒多目标血糖控制方法研究
Sharmistha Mandal,Ashoke Sutradhar
Sharmistha Mandal
In this study, an automatic robust multi-objective controller has been proposed for blood glucose (BG) regulation in Type-1 Diabetic Mellitus (T1DM) patient through subcutaneous route. The main objective of this work is to control the BG le...
Cancer adjuvant chemotherapy prediction model for non-small cell lung cancer [0.03%]
非小细胞肺癌辅助化疗的癌症预后模型
Russul Alanni,Jingyu Hou,Hasseeb Azzawi et al.
Russul Alanni et al.
Non-small cell lung cancer (NSCLC) is the most popular and dangerous type of lung cancer. Adjuvant chemotherapy (ACT) is the main treatment after surgery resection to prevent the patient from cancer recurrence. However, ACT could be toxic a...