PPDTS: Predicting potential drug-target interactions based on network similarity [0.03%]
PPDTS：基于网络相似性的潜在药物-靶标相互作用预测
Wei Wang,Yongqing Wang,Yu Zhang et al.
Wei Wang et al.
Identification of drug-target interactions (DTIs) has great practical importance in the drug discovery process for known diseases. However, only a small proportion of DTIs in these databases has been verified experimentally, and the computa...
A novel m6A-related prognostic signature for predicting the overall survival of hepatocellular carcinoma patients [0.03%]
与m6A相关的新型预后特征可预测肝细胞癌患者的总体生存率
Shiyang Xie,Yaxuan Wang,Jin Huang et al.
Shiyang Xie et al.
Liver hepatocellular carcinoma (LIHC) comprises most cases of liver cancer with a poor prognosis. N6 -methyladenosine (m6A) plays important biological functions in cancers. Thus, the present research was aimed to determine biomarkers of m6A...
Construction and characterization of rectal cancer-related lncRNA-mRNA ceRNA network reveals prognostic biomarkers in rectal cancer [0.03%]
直肠癌相关lncRNA-mRNA ceRNA网络的构建与特征分析揭示了直肠癌预后生物标志物
Guoying Cai,Meifei Sun,Xinrong Li et al.
Guoying Cai et al.
Rectal cancer is an important cause of cancer-related deaths worldwide. In this study, the differentially expressed (DE) lncRNAs/mRNAs were first identified and the correlation level between DE lncRNAs and mRNAs were calculated. The results...
Qi Ye,Bingo Wing-Kuen Ling,Nuo Xu et al.
Qi Ye et al.
Prehypertension is a new risky disease defined in the seventh report issued by the Joint National Commission. Hence, detecting prehypertension in time plays a very important role in protecting human lives. This study proposes a method for c...
Comprehensive investigation of RNA-sequencing dataset reveals the hub genes and molecular mechanisms of coronavirus disease 2019 acute respiratory distress syndrome [0.03%]
对RNA测序数据集的全面调查揭示了冠状病毒病2019年急性呼吸窘迫综合征的关键基因和分子机制
Wangsheng Deng,Jiaxing Zeng,Shunyu Lu et al.
Wangsheng Deng et al.
The goal of this study is to reveal the hub genes and molecular mechanisms of the coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome (ARDS) based on the genome-wide RNA sequencing dataset. The RNA sequencing dataset of ...
Variable structure robust controller design for blood glucose regulation for type 1 diabetic patients: A backstepping approach [0.03%]
基于后退步骤法的1型糖尿病患者血糖调节鲁邦变结构控制器设计
Mohamadreza Homayounzade
Mohamadreza Homayounzade
Diabetes mellitus type 1 occurs when β - cells in the pancreas are destroyed by the immune system. As a result, the pancreas cannot produce adequate insulin, and the glucose enters the cells to produce energy. To elevate the glycaemic...
Hongquan Peng,Haibin Zhu,Chi Wa Ao Ieong et al.
Hongquan Peng et al.
Accurate detection of chronic kidney disease (CKD) plays a pivotal role in early diagnosis and treatment. Measured glomerular filtration rate (mGFR) is considered the benchmark indicator in measuring the kidney function. However, due to the...
Adel A Alofairi,Emad Mabrouk,Ibrahim E Elsemman
Adel A Alofairi
The minimum dominating set (MDSet) comprises the smallest number of graph nodes, where other graph nodes are connected with at least one MDSet node. The MDSet has been successfully applied to extract proteins that control protein-protein in...
Long non-coding RNAs and their targets as potential biomarkers in breast cancer [0.03%]
长非编码RNA及其靶标作为乳腺癌生物标志物的潜力
Maryam Khalid,Rehan Zafar Paracha,Maryum Nisar et al.
Maryam Khalid et al.
Breast cancer is among the lethal types of cancer with a high mortality rate, globally. Its high prevalence can be controlled through improved analysis and identification of disease-specific biomarkers. Recently, long non-coding RNAs (lncRN...
Pathway-based protein-protein association network to explore mechanism of α-glucosidase inhibitors from Scutellaria baicalensis Georgi against type 2 diabetes [0.03%]
基于路径的蛋白质相互作用网络探索黄芩素化合物α-糖苷酶抑制剂防治2型糖尿病的作用机制
Le Wang,Wenbo Diwu,Nana Tan et al.
Le Wang et al.
Natural products have been widely used in the treatment of type 2 diabetes (T2D). However, their mechanisms are often obscured due to multi-components and multi-targets. The authors constructed a pathway-based protein-protein association (P...