Design and engineering of whole-cell biocatalyst for efficient synthesis of (R)-citronellal [0.03%]
全细胞生物催化剂的设计与工程化以高效合成(R)-香叶醛
Baoqi Zhang,Han Du,Yanqiu Zheng et al.
Baoqi Zhang et al.
Bioproduction of optical pure (R)-citronellal from (E/Z)-citral at high substrate loading remains challenging. Low catalytic efficiency of (R)-stereoselective ene reductases towards crude citral mixture is one of the major bottlenecks. Here...
Biotechnological production optimization of argyrins - a potent immunomodulatory natural product class [0.03%]
银菌素的生物技术生产优化——一种强有力的免疫调节天然产物类化合物
Domen Pogorevc,Rolf Müller
Domen Pogorevc
Argyrins represent a family of cyclic octapeptides exhibiting promising immunomodulatory activity via inhibiting mitochondrial protein synthesis, which leads to reduced IL-17 production by the T-helper 17 cells. Argyrins are formed by a non...
The rising dominance of microbiology: what to expect in the next 15 years? [0.03%]
微生物学日益增长的主导地位：在未来15年可以期待什么？
Roshan Kumar,Utkarsh Sood,Jasvinder Kaur et al.
Roshan Kumar et al.
What microbiology beholds after a decade and a half in the future requires a vision based on the facts and ongoing trends in research and technological advancements. While the latter, assisted by microbial dark matter, presents a greater po...
Ralph Bertram,Bernd Neumann,Christopher F Schuster
Ralph Bertram
The tetracycline repressor (TetR) belongs to the most popular, versatile and efficient transcriptional regulators used in bacterial genetics. In the tetracycline (Tc) resistance determinant tet(B) of transposon Tn10, tetR regulates the expr...
Max Cárdenas-Fernández,Oliver Sinclair,John M Ward
Max Cárdenas-Fernández
Transaminases (TAs) are promising biocatalysts for chiral amine synthesis; however, only few thermophilic TAs have been described to date. In this work, a genome mining approach was taken to seek novel TAs from nine thermophilic microorgani...
Faecal microbiota transplantation-mediated jejunal microbiota changes halt high-fat diet-induced obesity in mice via retarding intestinal fat absorption [0.03%]
粪便微生物移植介导的空肠菌群改变通过延缓肠道脂肪吸收来阻止高脂饮食引起的肥胖发生
Luoyi Zhu,Jie Fu,Xiao Xiao et al.
Luoyi Zhu et al.
Faecal Microbiota Transplantation (FMT) is considered as a promising technology to fight against obesity. Wild boar has leanermuscle and less fat in comparison to the domestic pig, which were thought to be related with microbiota. To invest...
In silico and in vivo analyses reveal key metabolic pathways enabling the fermentative utilization of glycerol in Escherichia coli [0.03%]
计算和体内分析揭示了大肠杆菌发酵利用甘油的关键代谢途径
James M Clomburg,Angela Cintolesi,Ramon Gonzalez
James M Clomburg
Most microorganisms can metabolize glycerol when external electron acceptors are available (i.e. under respiratory conditions). However, few can do so under fermentative conditions owing to the unique redox constraints imposed by the high d...
Soil initial bacterial diversity and nutrient availability determine the rate of xenobiotic biodegradation [0.03%]
土壤初始细菌多样性和营养物的可利用性决定了 Xenobiotic 生物降解的速度
Ramesha H Jayaramaiah,Eleonora Egidi,Catriona A Macdonald et al.
Ramesha H Jayaramaiah et al.
Understanding the relative importance of soil microbial diversity, plants and nutrient management is crucial to implement an effective bioremediation approach to xenobiotics-contaminated soils. To date, knowledge on the interactive effects ...
Scott N Dean,Meghna Thakur,Joseph R Spangler
Scott N Dean
This is a highlight on the article 'Extracellular vesicle formation in Lactococcus lactis is stimulated by prophage-encoded holin-lysin system' by Yue Liu, Eddy Smid and Tjakko Abee. ...