bZIP63.5 Regulates a Zinc-Finger Mediated Detoxification Network in Trichoderma Harzianum for Enhanced Biocontrol of Alternaria alternata [0.03%]
哈佐曼青霉中bZIP63.5通过调控锌指介导的解毒网络增强其对链格孢菌的控害能力
Yongfeng Yang,Huifang Zhang,Bin Liu et al.
Yongfeng Yang et al.
Trichoderma species are widely recognised as biocontrol agents, yet the transcriptional mechanisms underlying their antagonism against foliar pathogens remain largely unexplored. In this study, we identified 32 bZIP genes in Trichoderma har...
Adh1-Programmed SNF1 Phosphogradients Decrypt Morphogenesis in Candida albicans: Chemical Interrogation Unveils Hyphal Transition Thresholds [0.03%]
芽生型假丝酵母中由ADH1编程的SNF1磷酸化梯度解密了形态发生：化学检查揭示了菌丝过渡阈值
Ziqi Wang,Ziran Wang,Qi Zhang et al.
Ziqi Wang et al.
While Candida albicans alcohol dehydrogenase I (Adh1) conventionally functions as an alcohol dehydrogenase, this study builds upon previous work to redefine its novel role in regulating hyphal morphogenesis and elucidates the underlying mec...
Comparative Genomic and Transcriptomic Analysis Reveals Why Paenarthrobacter Strains Are Specialists in the Degradation of the Fungicide Iprodione [0.03%]
比较基因组和转录组分析揭示了Paenarthrobacter菌株为何擅长降解杀菌剂iprodone的原因
V Michelioudakis,A Zafranas,C Myrisiotis et al.
V Michelioudakis et al.
Paenarthrobacters degrade the fungicide iprodione through a pathway involving an amidase (IpaH), a deacetylase (DdaH) and a hydrolase (DuaH). We aimed to elucidate the mechanisms of this catabolic specialisation and its evolution in Paenart...
Comparative Study
Microbial biotechnology. 2026 Feb;19(2):e70319. DOI:10.1111/1751-7915.70319 2026
Next-Generation Microencapsulation Technologies for Probiotic Protection and Precision Delivery [0.03%]
下一代微胶囊技术在 probiotic保护和精准递送中的应用
Yixin Zhu,Longxian Lv,Bingbing Du et al.
Yixin Zhu et al.
Probiotics offer well-documented benefits, including improved gastrointestinal function, microbiota modulation, and immune enhancement. However, their therapeutic potential is limited by poor survival during oral delivery due to gastric aci...
Lactobacillus paragasseri LG-1 Alleviates Urticaria-Like Symptoms in Mice via Modulation of Gut Microbiota, Hypoxanthine and Uric Acid [0.03%]
乳酸菌 paragasseri LG-1通过调节肠道微生物群、次黄嘌呤和尿酸缓解小鼠类荨麻疹症状
Qiong Wang,Zhiming Hu,Yuqi Wang et al.
Qiong Wang et al.
Chronic Spontaneous Urticaria (CSU) is an immunoinflammatory disorder with complex pathogenesis. Emerging evidence implicates that gut microbiota dysbiosis plays a pivotal role in this pathological network. Integrated 16S rRNA sequencing an...
Mixed Waste Streams for Bioproduction: Exploring Bacterial Wax Ester Production in Nitrogen-Rich Acidogenic Fermentate [0.03%]
富含氮的酸性发酵副产物作为生物基生产的混合废物原料：探索细菌蜡酯生产
Laura K Martin,Wei E Huang,Ian P Thompson
Laura K Martin
Microbial lipids offer a promising alternative to petrochemicals, but high associated costs and low conversion efficiencies pose barriers to their commercialisation. In particular, sugar-based feedstocks are too expensive for the production...
Recent Developments in HIV Antivirals: The Prospect of Prophylactic Drugs to Change the Pandemic [0.03%]
HIV抗病毒药物的新进展：有望改变艾滋病流行的预防性药物的前景
Harald Brüssow
Harald Brüssow
The human immunodeficiency-1 virus was identified in 1983 as the etiological agent of AIDS. Four years later, the first HIV-1 antiviral drug was approved: the nucleoside analog zidovudine inhibiting the viral reverse transcriptase (RT). Sub...
Wood Hemicellulose-Based Spray-Dried Microencapsulation of a Lytic Bacteriophage Preserves Phage Viability and Improves Control of the Bacterial Wilt Pathogen Ralstonia solanacearum [0.03%]
基于木质半纤维素的喷雾干燥微包合噬菌体能够提高其活性并增强对青枯病原菌Ralstonia solanacearum的控制效果
Alba M Negroni,Connor G Hendrich,Minh Thao Ho et al.
Alba M Negroni et al.
Ralstonia solanacearum (RS) is a soil-borne phytopathogen responsible for bacterial wilt disease on a wide range of crops worldwide. Bacteriophage biocontrol is a promising sustainable RS management method. However, more work is needed to d...
Structured Promoter Variability in Epigenetically Regulated Operons Contributes to Surface Adaptation in Salmonella [0.03%]
沙门氏菌表观遗传调控操纵子中的结构化启动子多态性有助于其表面适应性
Rocío Fernández-Fernández,Gabriel Gutiérrez,Francine Piubeli et al.
Rocío Fernández-Fernández et al.
Bacterial adaptation to dynamic and hostile environments often relies on the ability to modify surface structures, which are subjected to strong selective pressures. While mutations in coding sequences that alter surface structures have lon...
Previously Uncharacterised Aliphatic Amino Acid Positions Modulate the Apparent Catalytic Activity of the EAL Domain of ZMO_1055 and Other Cyclic Di-GMP-Specific EAL Phosphodiesterases [0.03%]
一些未表征的脂族氨基酸位点通过调控反应活性调节EAL结构域的催化作用以及其他特异性的环二鸟苷酸EAL磷酸水解酶
Lian-Ying Cao,Xue Zhang,Feng-Wu Bai et al.
Lian-Ying Cao et al.
The nearly ubiquitous second messenger cyclic di-GMP signalling system decides about the bacterial lifestyle transition between sessility and motility. GGDEF diguanylate cyclase and EAL phosphodiesterase domains conventionally conduct the t...