Alejandro Arce-Rodríguez,Javier De la Peña Noya,José Manuel Borrero-de Acuña
Alejandro Arce-Rodríguez
Bacterial Extracellular Vesicles (bEVs) are lipid (single- or double-bilayer) nanostructures secreted by virtually all bacteria that play fundamental roles in intercellular communication and have emerged as powerful, multifunctional tools i...
Integrated Multi-Omics Analysis of a Periplaneta americana Symbiont Streptomyces sampsonii Strain WA1-19 Against Candida albicans [0.03%]
Zhiyu Chen,Wendi Mei,Jiale Tan et al.
Zhiyu Chen et al.
The rising infection caused by Candida albicans and emerging multi-drug resistance necessitates the development of innovative antimicrobial discovery pipelines. To overcome high discovery rates from conventional sources, this study utilised...
Correction to 'Wood Hemicellulose-Based Spray-Dried Microencapsulation of a Lytic Bacteriophage Preserves Phage Viability and Improves Control of the Bacterial Wilt Pathogen Ralstonia solanacearum' [0.03%]
Published Erratum
Microbial biotechnology. 2026 Apr;19(4):e70347. DOI:10.1111/1751-7915.70347 2026
Noémie De Zutter,Kris Audenaert
Noémie De Zutter
Global food systems face challenges from population growth, shifting diets and climate change. While decades of plant-centric breeding and high-input agriculture have generated high yielding crops, this strategy has unintentionally reshaped...
Javier Avalos,Luis M Corrochano
Javier Avalos
Antivirals Targeting Coronavirus RNA-Dependent RNA Polymerase and Main Protease: From Mechanisms of Action to Outcomes in COVID-19 Clinical Trials [0.03%]
针对冠状病毒RNA依赖性RNA聚合酶和主要蛋白酶的抗病毒药物：从作用机制到COVID-19临床试验结果
Harald Brüssow
Harald Brüssow
The rapid global spread of SARS-CoV-2 triggered an unprecedented effort to develop effective antivirals. Among the first approved agents was remdesivir, an injectable nucleoside analogue developed by Gilead Sciences, that led to chain termi...
Dynamic Lysine Acetylation Disrupts Isocitrate Lyase Function and Enables Metabolic Optimisation [0.03%]
动态的赖氨酸乙酰化破坏异柠檬酸裂解酶功能并实现代谢优化
Adrián Martínez-Vivancos,Beatriz Gomariz-Turpin,Gema Lozano-Terol et al.
Adrián Martínez-Vivancos et al.
Proteomic studies have suggested that Escherichia coli isocitrate lyase (ICL) undergoes multiple acetylation events, partially inhibiting its activity. However, the molecular basis of this regulation and the contribution of individual lysin...
Branched-Chain Amino Acids Mediate the Regulation of SACE_Lrp on the Aminotransferase IlvE Involved in Erythromycin Biosynthesis in Saccharopolyspora erythraea [0.03%]
支链氨基酸介导苏云金芽孢杆菌色红素调节因子Lrp对红霉素生物合成途径中转氨酶IlvE的调控作用研究
Xinlu Cai,Lijuan Tang,Yinuo Liu et al.
Xinlu Cai et al.
Erythromycin is a broad-spectrum polyketide antibiotic which can be obtained mainly through biosynthesis. The catabolic pathway of branched-chain amino acids (BCAAs) significantly influences the biosynthesis of erythromycin. However, the re...
Engineering Yeast Extracellular Vesicle Biogenesis Through Rewiring Membrane Trafficking Pathways [0.03%]
通过重新布线膜转运途径工程酵母细胞外囊泡生物发生
Yueyan Li,XiaoRan Ma,Lichao Zhang et al.
Yueyan Li et al.
Extracellular vesicles (EVs) are emerging as versatile therapeutic platforms, yet the mechanisms governing their biogenesis in yeast remain incompletely understood. Saccharomyces cerevisiae, a well-characterised and safe microbial chassis, ...
Influence of Ploidy and Genetic Background on Stress Tolerance of Intraspecific Yeast Hybrids [0.03%]
同种酿酒酵母杂交子的基因组倍性和遗传背景对其胁迫耐受性的影响
Kaisa Rinta-Harri,Tino Koponen,Dominik Mojzita et al.
Kaisa Rinta-Harri et al.
Hybrid vigour, or heterosis, is widely exploited in yeast strain improvement. Yet, how ploidy and genetic background jointly shape heterosis across industrially relevant stresses remains unclear. Here, we generated 1023 Saccharomyces cerevi...