A Scaffoldomics Platform for Modular In Vivo Enzyme Colocalisation and Its Application to Naringenin Biosynthesis [0.03%]
一种用于模块化体内酶共定位的支架组学平台及其在柚皮素生物合成中的应用
Marte Elias,Brecht De Paepe,Julie Vanderstraeten et al.
Marte Elias et al.
Insufficient product yield remains a major bottleneck in the development of microbial cell factories for fine chemical production. In vivo enzyme colocalisation on synthetic scaffolds has emerged as a promising strategy to enhance metabolic...
Vaginal-Derived Potential Probiotics and Their Postbiotics Alleviate Aerobic Vaginitis via Suppressing TLR4/MyD88/NF-κB Signalling Pathway and Potentially Enhancing Vaginal Barrier [0.03%]
阴道来源潜在益生菌及其后生素通过抑制TLR4/MyD88/NF-κB信号通路并可能增强阴道屏障来缓解需氧性阴道炎
Meiyun Tian,Xinyi Zhang,Xuan Xu et al.
Meiyun Tian et al.
Antibiotic therapy is currently challenged by drug resistance and high recurrence in aerobic vaginitis (AV), making it urgent to seek novel strategies. In this study, we selected two potential probiotic strains Lactobacillus crispatus YBR-0...
Advance Microbiota Transplantation: A Novel Addition-Subtraction Paradigm for Optimising Faecal Microbiota Transplantation [0.03%]
先进的微生物群移植：优化粪便菌群移植的新增加-减去范式
Haojia Lin,Zelin Feng,Qiuyue Tu et al.
Haojia Lin et al.
Faecal microbiota transplantation (FMT) is highly effective for recurrent Clostridioides difficile infection but yields inconsistent benefits in chronic indications. As a crude whole-microbiota transplant, FMT contains numerous undefined ac...
Pseudolaric Acid B Combats Drug-Resistant Candida albicans Infection via Dual-Action Mechanisms of Direct Antifungals and Vaginal Microbiota Restoration [0.03%]
伪报春酸B通过直接抗真菌和恢复阴道微生态的双机制对抗耐药白色念珠菌感染
Tianmeng Shao,Yunshan Zhang,Binqing Xue et al.
Tianmeng Shao et al.
Candidal vaginitis is a prevalent inflammatory condition of the reproductive tract that has a substantial impact on women's health. Conventional antibiotic therapy frequently results in recurrence due to the non-selective elimination of vag...
Efficient Extracellular Production of Insulin Glargine in Trichoderma reesei by an Integrative Secretion-Based Strategy [0.03%]
整合分泌策略有效提高木霉胞外胰岛素格列聘生产题目中的“Insulin Glargine”可以译为长效胰岛素类似物艾塞那肽或格列聘，此处建议统一翻译为“胰岛素格列聘”。所以正确的翻译是：基于分泌的整合策略下有效提高木霉胞外胰岛素格列聘的生产
Aiqin Yan,Xihai Li,Di Zhang et al.
Aiqin Yan et al.
Insulin glargine, a long-acting insulin analog, is essential for diabetes treatment. However, its industrial production remains challenging due to limitations in conventional expression systems. Here, we employed the industrial filamentous ...
Multi-Omics Reveals Phenethyl Acetate and Its Producer Lactiplantibacillus plantarum as Key Drivers of Enhanced Palatability in Alfalfa Silage [0.03%]
多组学揭示飞燕草酯及其生产菌植物乳杆菌为提高苜蓿青贮适口性的关键物质与微生物
Zhihui Fu,Tianwei Wang,Jiaqi Zhang et al.
Zhihui Fu et al.
High-quality silage enhances palatability and feed intake; however, the effects of co-fermentation with flavouring agents and lactic acid bacteria (LAB) on its flavour quality, core microbiota, and taste-active amino acids remain unclear. T...
Functional Evaluation of a Conserved HNH Endonuclease Gene in Lactococcal Skunavirus Genomes [0.03%]
乳酸菌Skunavirus基因组中保守的HNH内切酶基因的功能评价
Jun-Hyeok Yu,Frank Hille,Christian Cambillau et al.
Jun-Hyeok Yu et al.
Skunavirus is the most frequently encountered Lactococcus-infecting (bacterio)phage genus in dairy fermentations and may cause milk acidification failure or inefficiencies. During phage infection, DNA packaging into the phage prohead is a c...
bZIP63.5 Regulates a Zinc-Finger Mediated Detoxification Network in Trichoderma Harzianum for Enhanced Biocontrol of Alternaria alternata [0.03%]
哈佐曼青霉中bZIP63.5通过调控锌指介导的解毒网络增强其对链格孢菌的控害能力
Yongfeng Yang,Huifang Zhang,Bin Liu et al.
Yongfeng Yang et al.
Trichoderma species are widely recognised as biocontrol agents, yet the transcriptional mechanisms underlying their antagonism against foliar pathogens remain largely unexplored. In this study, we identified 32 bZIP genes in Trichoderma har...
Adh1-Programmed SNF1 Phosphogradients Decrypt Morphogenesis in Candida albicans: Chemical Interrogation Unveils Hyphal Transition Thresholds [0.03%]
芽生型假丝酵母中由ADH1编程的SNF1磷酸化梯度解密了形态发生：化学检查揭示了菌丝过渡阈值
Ziqi Wang,Ziran Wang,Qi Zhang et al.
Ziqi Wang et al.
While Candida albicans alcohol dehydrogenase I (Adh1) conventionally functions as an alcohol dehydrogenase, this study builds upon previous work to redefine its novel role in regulating hyphal morphogenesis and elucidates the underlying mec...
Comparative Genomic and Transcriptomic Analysis Reveals Why Paenarthrobacter Strains Are Specialists in the Degradation of the Fungicide Iprodione [0.03%]
比较基因组和转录组分析揭示了Paenarthrobacter菌株为何擅长降解杀菌剂iprodone的原因
V Michelioudakis,A Zafranas,C Myrisiotis et al.
V Michelioudakis et al.
Paenarthrobacters degrade the fungicide iprodione through a pathway involving an amidase (IpaH), a deacetylase (DdaH) and a hydrolase (DuaH). We aimed to elucidate the mechanisms of this catabolic specialisation and its evolution in Paenart...
Comparative Study
Microbial biotechnology. 2026 Feb;19(2):e70319. DOI:10.1111/1751-7915.70319 2026