Highly Sensitive Field Detection Technology for Anthrax Based on the CRISPR/Cas13a System [0.03%]
基于CRISPR / Cas13a系统的高灵敏度检测炭疽杆菌的场检测技术
Jiao Fan,Luyao Huang,Jiahui Chen et al.
Jiao Fan et al.
In this study, we established a highly sensitive on-site detection technology for Bacillus anthracis. Firstly, we integrated Multiple Enzyme Isothermal Rapid Amplification (MIRA) with the clustered regularly interspaced short palindromic re...
Modulating Surfactin Biosynthesis in Bacillus subtilis R31 Enhances Behavioural Traits and Biocontrol Efficacy Against Banana Fusarium Wilt [0.03%]
调节枯草芽孢杆菌R31中表面活性素的生物合成可增强其调控行为和防治香蕉镰刀菌 wilt病的功效
Hao-Jun Chen,Yue Liu,Yun-Shan Zhong et al.
Hao-Jun Chen et al.
Surfactin, a lipopeptide antibiotic and quorum-sensing (QS) mediator from Bacillus subtilis, has dual functions in microbial ecology and plant disease suppression. This study engineered B. subtilis R31 to overproduce comK and phrC, key regu...
Lisa Friess,Douwe van Sinderen,Ciaran Lee
Lisa Friess
This work describes the development of a CRISPR interference (CRISPRi) system for targeted gene repression in bifidobacteria. We first validated the CRISPRi-based approach using Bifidobacterium breve strains engineered to express nuclease-d...
Attenuated Strains of Pseudomonas aeruginosa: A Promising Cell Factory for Rhamnolipid Production [0.03%]
铜绿假单胞菌低毒株工程化生产鼠李糖脂的潜力
Parvathy V Das,Meagan E Valentine,Timothy E Long et al.
Parvathy V Das et al.
Biodegradable compounds like rhamnolipids provide an environmentally friendly alternative to petroleum-based surfactants. Pseudomonas aeruginosa is the most proficient producer of rhamnolipids. The genetic plasticity and metabolic versatili...
Lactiplantibacillus plantarum Attenuates Diet-Induced Obesity and Insulin Resistance Through Gut Microbiota-Driven PPAR/PI3K-Axis Modulation [0.03%]
植物乳植杆菌通过肠道菌群驱动的PPAR / PI3K轴调节缓解饮食诱导的肥胖和胰岛素抵抗
Yecheng Gao,Anqi Zhu,Jingjin Li et al.
Yecheng Gao et al.
LPPerfectus001 (LPP; GDMCC 62334) is a strain isolated from traditional pickled vegetables and identified as Lactiplantibacillus plantarum by 16s rRNA sequencing and biochemical analysis. Whole-genome sequencing and functional prediction re...
Protective Effect of Pediococcus pentosaceus Li05 on Constipation via TGR5/TPH1/5-HT Activation [0.03%]
戊糖片球菌Li05通过TGR5/TPH1/5-HT激活缓解便秘的保护作用
Hui Chen,Fengjiao Wang,Shengjie Li et al.
Hui Chen et al.
Pediococcus pentosaceus Li05, a strain of lactic acid bacteria isolated from the faeces of healthy volunteers, exhibited potential protective effects against various diseases. This study performed third-generation sequencing and detailed ch...
Liver-Microbiome Crosstalk Mediates the Protective Effects of Artemisinin in Clostridium perfringens Models [0.03%]
青蒿素通过肝脏-微生物组相互作用在产气荚膜梭菌模型中产生保护效应
Haodong Han,Youhao Li,Lili Wang et al.
Haodong Han et al.
Clostridium perfringens is a multi-host opportunistic pathogen whose plasmid-encoded toxins cause gas gangrene, necrotic enteritis and enterotoxemia, resulting in substantial economic losses in animal husbandry. In light of antibiotic bans ...
Biopolitics and the Ethical Dilemmas of Biotechnology: Lessons From the Pandemic [0.03%]
生物政治与生物技术伦理困境：大流行病带来的教训
Ioannis Economidis
Ioannis Economidis
The COVID-19 pandemic has underscored the urgent need for sustainability-driven biotechnology that strikes a balance between economic development, environmental stewardship and social impact, all while upholding fundamental human rights. ...
Baseline Fusobacterium Abundance Predicts Ustekinumab Response in Crohn's Disease: A Prospective Microbiome Cohort Study [0.03%]
基线菌群弗氏拟杆菌丰度可预测克罗恩病乌司奴单抗的治疗反应：一项前瞻性菌群队列研究
Chengran Wang,Yanping Hao,Yunyun Liu et al.
Chengran Wang et al.
The gut microbiota composition in Crohn's disease (CD) patients may influence their response to ustekinumab (UST) therapy. A total of 51 patients with active CD undergoing UST therapy were prospectively enrolled. Clinical activity was evalu...
Early-Life Ceftriaxone-Induced Gut Microbiota Perturbation Persistently Exacerbates Juvenile ADHD-Like Behaviours via Immune Dysfunction in SHR/WKY Rats [0.03%]
早年生活中由环丙沙星诱导的肠道菌群紊乱通过免疫功能障碍持久加剧了SHR/WKY大鼠的多动症行为
Yang Yang,Simou Wu,Jianxiu Liu et al.
Yang Yang et al.
This study investigated the impact of ceftriaxone-induced gut microbiota perturbation in neonatal male spontaneous hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats during lactation on the development of juvenile ADHD symptoms. The 5-choi...