Javier Avalos,Luis M Corrochano
Javier Avalos
Antivirals Targeting Coronavirus RNA-Dependent RNA Polymerase and Main Protease: From Mechanisms of Action to Outcomes in COVID-19 Clinical Trials [0.03%]
针对冠状病毒RNA依赖性RNA聚合酶和主要蛋白酶的抗病毒药物：从作用机制到COVID-19临床试验结果
Harald Brüssow
Harald Brüssow
The rapid global spread of SARS-CoV-2 triggered an unprecedented effort to develop effective antivirals. Among the first approved agents was remdesivir, an injectable nucleoside analogue developed by Gilead Sciences, that led to chain termi...
Dynamic Lysine Acetylation Disrupts Isocitrate Lyase Function and Enables Metabolic Optimisation [0.03%]
动态的赖氨酸乙酰化破坏异柠檬酸裂解酶功能并实现代谢优化
Adrián Martínez-Vivancos,Beatriz Gomariz-Turpin,Gema Lozano-Terol et al.
Adrián Martínez-Vivancos et al.
Proteomic studies have suggested that Escherichia coli isocitrate lyase (ICL) undergoes multiple acetylation events, partially inhibiting its activity. However, the molecular basis of this regulation and the contribution of individual lysin...
Branched-Chain Amino Acids Mediate the Regulation of SACE_Lrp on the Aminotransferase IlvE Involved in Erythromycin Biosynthesis in Saccharopolyspora erythraea [0.03%]
支链氨基酸介导苏云金芽孢杆菌色红素调节因子Lrp对红霉素生物合成途径中转氨酶IlvE的调控作用研究
Xinlu Cai,Lijuan Tang,Yinuo Liu et al.
Xinlu Cai et al.
Erythromycin is a broad-spectrum polyketide antibiotic which can be obtained mainly through biosynthesis. The catabolic pathway of branched-chain amino acids (BCAAs) significantly influences the biosynthesis of erythromycin. However, the re...
Engineering Yeast Extracellular Vesicle Biogenesis Through Rewiring Membrane Trafficking Pathways [0.03%]
通过重新布线膜转运途径工程酵母细胞外囊泡生物发生
Yueyan Li,XiaoRan Ma,Lichao Zhang et al.
Yueyan Li et al.
Extracellular vesicles (EVs) are emerging as versatile therapeutic platforms, yet the mechanisms governing their biogenesis in yeast remain incompletely understood. Saccharomyces cerevisiae, a well-characterised and safe microbial chassis, ...
Influence of Ploidy and Genetic Background on Stress Tolerance of Intraspecific Yeast Hybrids [0.03%]
同种酿酒酵母杂交子的基因组倍性和遗传背景对其胁迫耐受性的影响
Kaisa Rinta-Harri,Tino Koponen,Dominik Mojzita et al.
Kaisa Rinta-Harri et al.
Hybrid vigour, or heterosis, is widely exploited in yeast strain improvement. Yet, how ploidy and genetic background jointly shape heterosis across industrially relevant stresses remains unclear. Here, we generated 1023 Saccharomyces cerevi...
Washed Microbiota Transplantation as a Rescue Therapy for Refractory Unidentified Pathogen Intestinal Infections: Findings From a National Multi-Centre, Real-World Study [0.03%]
万级微生物菌群移植治疗难治性不明病原体肠道感染的真实世界研究
Sheng Zhang,Pan Li,Min Dai et al.
Sheng Zhang et al.
Unidentified pathogen intestinal infections (UPIIs) represent a severe clinical dilemma, characterised by clear signs of intestinal infection yet no identifiable causative pathogen, often leading to prolonged, antibiotic-refractory illness....
Multicenter Study
Microbial biotechnology. 2026 Mar;19(3):e70335. DOI:10.1111/1751-7915.70335 2026
Danyang Wang,Ruirui Cui,Chang You et al.
Danyang Wang et al.
The nervous system and the immune system are integral components of the tumour microenvironment, and neuroimmune mechanisms play critical roles in tumour metastasis, immune evasion and metabolic reprogramming. However, the relationship betw...
Thermotolerant D-Hydantoinases for Efficient and Stereoselective Intermediate Synthesis of (R)-3-Isobutylglutaric Acid Monoamide, a Key Intermediate in Pregabalin Production [0.03%]
耐热型D-水杨醛缩氨基硫脲酶高效立体选择性合成(R)-3-异丁基谷酰胺单酰胺茋𬭩盐𬭩盐，一种(pregabalin)关键中间体
Jiujiuzi Zhang,Bin Zhi,Zhenyu Xie et al.
Jiujiuzi Zhang et al.
Pregabalin is a widely used clinical pharmaceutical agent for treatment of neuropathic pain and as an adjunctive therapy for epilepsy. The efficient synthesis of (R)-3-isobutylglutaric acid monoamide (R-IBM), a critical intermediate, is cru...
Precision Microbial Therapeutics for Infertility: Next-Generation Probiotics, Engineered Biologics and Translational Pathways [0.03%]
精准微生物治疗不孕症：下一代益生菌、工程化生物制品和转化路径
Limiao Li,Lin Feng,Qiang Li et al.
Limiao Li et al.
Infertility affects ~1 in 6 people of reproductive age and remains difficult to treat because causes are heterogeneous and diagnostics are incomplete. Recent evidence reframes the female reproductive tract as a low-biomass but biologically ...