Baseline Fusobacterium Abundance Predicts Ustekinumab Response in Crohn's Disease: A Prospective Microbiome Cohort Study [0.03%]
基线菌群弗氏拟杆菌丰度可预测克罗恩病乌司奴单抗的治疗反应：一项前瞻性菌群队列研究
Chengran Wang,Yanping Hao,Yunyun Liu et al.
Chengran Wang et al.
The gut microbiota composition in Crohn's disease (CD) patients may influence their response to ustekinumab (UST) therapy. A total of 51 patients with active CD undergoing UST therapy were prospectively enrolled. Clinical activity was evalu...
Early-Life Ceftriaxone-Induced Gut Microbiota Perturbation Persistently Exacerbates Juvenile ADHD-Like Behaviours via Immune Dysfunction in SHR/WKY Rats [0.03%]
早年生活中由环丙沙星诱导的肠道菌群紊乱通过免疫功能障碍持久加剧了SHR/WKY大鼠的多动症行为
Yang Yang,Simou Wu,Jianxiu Liu et al.
Yang Yang et al.
This study investigated the impact of ceftriaxone-induced gut microbiota perturbation in neonatal male spontaneous hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats during lactation on the development of juvenile ADHD symptoms. The 5-choi...
Democratising Artificial Intelligence for Pandemic Preparedness and Global Governance in Latin American and Caribbean Countries [0.03%]
拉丁美洲和加勒比国家的疫情准备和全球治理的人工智能民主化
Ulisses Rocha,Robson Bonidia,Jude Dzevela Kong et al.
Ulisses Rocha et al.
Infectious diseases continue to pose a significant global health challenge, necessitating innovative approaches for predicting outbreaks, detecting variants, conducting contact tracing, discovering new drugs and managing misinformation. Art...
Novel Anthraquinone Chlorination Contributes to Pigmentation and ATP Formation in Thermomyces dupontii [0.03%]
新颖的蒽醌氯化作用参与Thermomyces dupontii的色素生成和ATP形成
Donglou Wang,Gang Dai,Jiangbo He et al.
Donglou Wang et al.
Fungal pigments, particularly anthraquinones, play critical roles in food industrial applications due to their vivid hues and bioactive properties. Despite their significance, the functional mechanisms underlying pigment variation and their...
Identification of MscS as a Key L-Glutamate Exporter in Bacillus methanolicus [0.03%]
芽孢杆菌MscS是重要的L-谷氨酸外排蛋白
Luciana Fernandes Brito,Davide Luciano,Marta Irla et al.
Luciana Fernandes Brito et al.
Small-conductance mechanosensitive channels (MscS) are established l-glutamate exporters in industrially relevant bacteria, yet their role in the methylotrophic bacterium Bacillus methanolicus, a promising platform for sustainable methanol-...
Production of the Antimicrobial Roseoflavin With Genetically Engineered Corynebacterium glutamicum [0.03%]
利用基因工程谷氨酸棒杆菌生产抗菌化合物玫瑰素
Luciana Fernandes Brito,Ane Bræin Aas,Rosa Jodalen Rudberg et al.
Luciana Fernandes Brito et al.
The global rise of drug-resistant bacterial infections underscores an urgent demand for novel antimicrobial agents. Roseoflavin, a naturally occurring riboflavin analog, has emerged as a promising candidate for drug development. In this stu...
AraC-Family Transcriptional Regulator WhpR Controls Virulence in Pseudomonas savastanoi pv. savastanoi Through Regulation of Indole Metabolism [0.03%]
潘氏噬节链霉菌色氨酸P蛋白通过调节吲哚代谢控制潘氏savastanoi致病性
Antonio Arroyo-Mateo,Jesús Leal-López,Luis Rodríguez-Moreno et al.
Antonio Arroyo-Mateo et al.
The Pseudomonas syringae complex WHOP genomic island underpins virulence in woody hosts by mediating the catabolism of aromatic compounds. However, the biochemical functions of the ipoABC and dhoAB operons and the regulatory gene whpR remai...
Development of a Ready-To-Use Bioluminescence Immunosensor for the One-Step Sensitive Detection of Antibodies Against African Swine Fever Virus [0.03%]
一种用于一步法灵敏检测非洲猪瘟病毒抗体的即用型生物发光免疫传感器的发展研究
Zhonghui Zhang,Xuesai Li,Qingli Niu et al.
Zhonghui Zhang et al.
Rapid and reliable analytical techniques play important roles in various research fields and are particularly crucial for diagnosing infectious diseases in clinical settings. African swine fever (ASF) is a devastating viral pig disease for ...
Chromosome III Aneuploidy Enhances Ethanol Tolerance in Industrial Saccharomyces cerevisiae by Increasing the TUP1 Copy Number [0.03%]
III号染色体非整倍性通过增加TUP1拷贝数提高工业酿酒酵母的乙醇耐受性
Sonia Albillos-Arenal,Javier Alonso Del Real,Ana Cristina Adam et al.
Sonia Albillos-Arenal et al.
Ethanol stress poses a considerable challenge for Saccharomyces cerevisiae during fermentation. Strains carrying an extra copy of chromosome III exhibit enhanced ethanol tolerance. Here, we investigated the underlying mechanisms of this tol...
The Role of Phyllosphere Microbes and Viruses in Biocontrol of Pathogenic Fungi [0.03%]
植物微生物和病毒拮抗病原真菌的机制及作用
Li Bi,Zahra F Islam,Lok-Hang Chan et al.
Li Bi et al.
The phyllosphere, the aerial surfaces of plants, represents a primary entry point for airborne fungal pathogens, posing a critical challenge to plant health and productivity. The phyllosphere hosts diverse microbial communities that play a ...