Lena Friebel,Thorsten Mascher,Christin Baumgärtel
Lena Friebel
Microorganisms, while being fundamental to life on Earth, are often associated with negative perceptions and global crises. The underlying lack of microbial literacy hinders the ability to make informed decision-making on global challenges ...
Scientists' Warning to Humanity: Unnecessary Bureaucracy Is a Global Impediment to Productivity, Advancement of Human and Planetary Wellbeing, Science and Sustainability [0.03%]
科学家警告：冗余官僚体制是阻碍人类和地球福祉、科学及可持续性发展的全球障碍
Kenneth Timmis,Zeynep Ceren Karahan,Jennifer A Byrne et al.
Kenneth Timmis et al.
Bureaucracies are essential to the proper functioning of almost all human activities. However, they are diverse in their quality and success-promoting potential. While many bureaucratic measures make sense and are necessary for the wellbein...
Kineochelins-A New Group of Siderophores From an Antarctic Bacterium [0.03%]
天冬氨酸型细菌铁载体 Kineochelin A 的分离纯化及结构鉴定
Stanislava Kralova,Peter Spacek,Johannes Gafriller et al.
Stanislava Kralova et al.
The global rise of antimicrobial resistance has intensified the search for new microbial metabolites from underexplored environments and taxonomic groups. Extreme and geographically isolated habitats such as Antarctic terrestrial ecosystems...
Isolation of a Novel Lytic Pseudomonas aeruginosa Phage Henu5 and Fitness Costs of Phage-Driven Resistance [0.03%]
一种新型裂解性铜绿假单胞菌噬菌体Henu5的分离及其驱动抗性的适应代价分析
Salwa E Gomaa,Jiawen Shen,Jingjing Li et al.
Salwa E Gomaa et al.
Phage therapy is increasingly recognised as a potential approach against antibiotic-resistant infections. Analogous to the rise of antibiotic resistance, bacteria can also evolve phage resistance, a process that frequently entails fitness c...
Identification of the Integration/Excision Module and Regulatory Elements Involved in the Mobility of IME8, an Integrative and Mobilizable Element From Mosquitocidal Lysinibacillus sphaericus [0.03%]
用于蚊蝇杀虫环状因子IME8自主转移的整合/切除模块和调控元件的鉴定
Yifeng Hu,Ying Yang,Xiaomin Hu et al.
Yifeng Hu et al.
Lysinibacillus sphaericus, a bacterium successfully used in the control of mosquitoes, bears its insecticidal traits in GI8, a recently identified mosquitocidal genomic island. GI8 is renamed IME8 in the present work, as it displays a typic...
A Cell-Penetrating Peptide-Derived Fluorescent Probe for Selective Isolation of Bacterial Spores [0.03%]
一种细胞穿透肽衍生物荧光探针及其选择性鉴别细菌芽胞的应用
Jaeyoung Yu,Tatsuru Okazaki,Yugo Kawabuchi et al.
Jaeyoung Yu et al.
In this study, we identify a peptide discovered through fluorescence-based screening of a cell-penetrating peptide (CPP) library that preferentially associates with bacterial spores and evaluate its utility as a fluorescence-guided tool for...
Extending the Targets for Coronavirus Antivirals Beyond That of Approved Drugs: Insights From Preclinical Research [0.03%]
从临床前研究中获得的关于新型冠状病毒抗病毒药物的见解超越了已批准的药物的目标范围
Harald Brüssow
Harald Brüssow
Antiviral drugs have been approved for the treatment of COVID-19. However, they present pharmacological limitations, a mixed efficacy profile and target just two coronavirus proteins. To extend the range of druggable coronavirus proteins, r...
A Stereospecific Lactic Acid Exclusion Biosensor for Grass Silage Fed Green Biorefinery [0.03%]
一种立体选择性的乳酸排除型生物传感器用于青贮饲料的绿色生物精炼过程
Roderick N van Roosmalen,Cormac D Murphy,Joseph B Sweeney
Roderick N van Roosmalen
Grass silage fed green biorefineries require high quality grass silage leachates to produce high quality products. Real-time, cost-effective methods to monitor key leachate analytes are needed for small-scale decentralised systems. In this ...
Incorporation of Cryptic Plasmid Energetics Improves Genome-Scale Metabolic Predictions in Probiotic E. coli Nissle 1917 [0.03%]
将密码质粒能量学纳入可改善对人体益生菌大肠杆菌尼丝莱1917的基因组范围代谢预测
Paola Corbín-Agustí,Alba Arévalo-Lalanne,Patricia Álvarez et al.
Paola Corbín-Agustí et al.
Escherichia coli Nissle 1917 (EcN) is a well-characterized Gram-negative probiotic distinguished by its unique, strain-specific physiology. Genome-scale metabolic models (GEMs) are powerful tools for elucidating metabolic traits and predict...