Monkeypox Virus: WHO's Second Public Health Emergency of International Concern Within 2 Years [0.03%]
猴痘病毒：世卫组织两年内宣布的第二种国际关注的突发公共卫生事件
Harald Brüssow
Harald Brüssow
An upsurge of monkeypox disease (mpox) cases with clade I virus in Central Africa led WHO to declare a Public Health Emergency of International Concern for a second time shortly after the worldwide clade II mpox epidemic in 2022/3 among hom...
Metabolic Engineering of a Serotonin Overproducing Saccharomyces cerevisiae Strain [0.03%]
代谢工程改造能过量产生五羟色胺的酿酒酵母菌株
Andrés Planells-Cárcel,Elena Valera-García,Guillermo Quintas et al.
Andrés Planells-Cárcel et al.
The EU Green Deal prioritises the transformation of the chemical industry to a more environmentally sustainable model. This involves using microorganisms, such as Saccharomyces cerevisiae, to produce molecules more sustainably through biote...
Gamifying Science-Novel Strategies for Bringing Microbiology to the Classroom [0.03%]
游戏化科学——将微生物学引入课堂的创新策略
Carlos Del Cerro-Sánchez,Vanesa Amarelle,Raúl Platero et al.
Carlos Del Cerro-Sánchez et al.
Microbes are essential in every environment, with an important role in the fight against climate change. Promoting microbiology literacy, especially among children, is crucial. Our Ibero-American consortium uses gamification to make science...
Variation of Meat Quality and Relationship to Gut Microbiota Among Different Pig Breeds [0.03%]
不同猪种的肉质变化及其与肠道菌群的关系
Qifan Zhang,Man Du,Siyu Wei et al.
Qifan Zhang et al.
Meat production is of great importance to the world's food supply and economic development, and meat quality determines the purchasing desire of consumers. Recent studies show intestinal microorganisms are involved in several physiological ...
Unravelling the Glycan Code: Molecular Dynamics and Quantum Chemistry Reveal How O-Glycan Functional Groups Govern OgpA Selectivity in Mucin Degradation by Akkermansia muciniphila [0.03%]
解开糖链编码的奥秘：分子动力学和量子化学揭示了O-聚糖功能基团如何支配Akkermansia muciniphila中OgpA的选择性降解黏蛋白中的选择性
Mohammad Khavani,Aliyeh Mehranfar,Mohammad R K Mofrad
Mohammad Khavani
Mucins, heavily O-glycosylated glycoproteins, are a key component of mucus, and certain gut microbiota, including Akkermansia muciniphila, can utilise mucin glycans as a carbon source. Akkermansia muciniphila produces the O-glycopeptidase e...
Exploring Yeast's Energy Dynamics: The General Stress Response Lowers Maintenance Energy Requirement [0.03%]
探索酵母的能量动力学：广义压力响应降低维持能量需求
Nuran Temelli,Simon van den Akker,Ruud A Weusthuis et al.
Nuran Temelli et al.
In many microbial biotechnology processes, biomass itself is not the product of interest, but rather targeted chemicals or proteins. In these processes, growth should be limited to direct more substrate to product and increase process yield...
De Novo Biosynthesis of Antidepressant Psilocybin in Escherichia coli [0.03%]
在大肠杆菌中从头生物合成抗抑郁化合物裸盖菇素
Zhangrao Huang,Yongpeng Yao,Rouyu Di et al.
Zhangrao Huang et al.
Psilocybin, a tryptamine-derived alkaloid, has been granted Breakthrough Therapy designation by the U.S. FDA for treatment-resistant depression, underscoring its clinical importance. Therefore, sustainable and economic production is urgentl...
Genetic Dissection of Cyclic di-GMP Signalling in Pseudomonas aeruginosa via Systematic Diguanylate Cyclase Disruption [0.03%]
通过系统性双链腺苷二磷酸cyclase基因敲除对绿脓杆菌c-di-GMP信号传导的遗传分析
Román A Martino,Daniel C Volke,Albano H Tenaglia et al.
Román A Martino et al.
The second messenger bis-(3' → 5')-cyclic dimeric guanosine monophosphate (c-di-GMP) governs adaptive responses in the opportunistic pathogen Pseudomonas aeruginosa, including biofilm formation and the transition from acute to chronic infe...
A Single-Plasmid Inducible-Replication System for High-Yield Production of Short Ff (f1, M13 or fd)-Phage-Derived Nanorods [0.03%]
一种单质粒感应型复制系统，用于短ff(f1、M13或fd)噬菌体衍生纳棒的高产生成
Rayén Ignacia León-Quezada,Majela González Miró,Sofia Khanum et al.
Rayén Ignacia León-Quezada et al.
Ff (f1, M13 or fd) filamentous phages have been used for myriad applications including phage display, assembly of nanostructures and as carriers of agents used for diagnostic and therapeutic purposes. Recently, short Ff phage-derived functi...
Designer Glycolysomes: Colocalisation of Glycolytic Enzymes on a Cellulosome-Based Synthetic Protein Scaffold [0.03%]
设计的糖基体：基于纤维小体的合成蛋白质支架上糖酵解酶的共定位
Marte Elias,Kenan Meert,Julie Vanderstraeten et al.
Marte Elias et al.
In systems biocatalysis, combining pathway enzymes in vitro allows for the conversion of basic substrates into more complex, valuable chemicals. However, in vitro enzyme cascades are not yet economically viable for large-scale bio-based che...