Theodoros Panou,Evanthia Gouveri,Djordje S Popovic et al.
Theodoros Panou et al.
Background: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have revolutionized treatment for type 2 diabetes mellitus (T2DM), obesity and beyond. Current research focuses on the use of the dual agonist of glucagon-l...
Vitor José Poletto Ferreira,Alessandra Fatima da Costa,Renan Pedra Souza et al.
Vitor José Poletto Ferreira et al.
Background: Hereditary factor X (FX) deficiency (FXD) leads to bleeds. Therapy is based on treating (episodic) or preventing (prophylaxis) bleeds with procoagulants. We aimed to evaluate the efficacy/effectiveness and saf...
Complement C5 inhibitor crovalimab for the treatment of paroxysmal nocturnal hemoglobinuria [0.03%]
补体C5抑制剂crovalimab治疗阵发性夜间血红蛋白尿症
Tianqiao Zhang,Bo Xu,Jixiang Chen et al.
Tianqiao Zhang et al.
Introduction: Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal hematopoietic stem cell disease characterized by hemolytic anemia, bone marrow failure, and thrombosis. Some PNH patients carrying the C5 mutation (Arg88...
New therapies to treat nausea and vomiting: the clinical need, progress towards novelty and research challenges [0.03%]
治疗恶心和呕吐的新疗法：临床需求、创新进展及研究挑战
Gareth J Sanger,John F Golding,Paul Lr Andrews
Gareth J Sanger
Introduction: Despite the availability of drugs which prevent vomiting, treatment gaps in controlling nausea and vomiting remain. New approaches are needed. ...
Predictors of warfarin therapeutic dose across thromboembolic indications: an exploratory early clinical evaluation study using machine learning-integrated explainable artificial intelligence and Bayesian models [0.03%]
探索华法林抗凝治疗预测因素及其剂量估算模型的建立与验证——基于机器学习可解释性人工智能及贝叶斯方法的早期临床评估研究
Kannan Sridharan,Gowri Sivaramakrishnan
Kannan Sridharan
Background: Warfarin dosing varies widely due to genetic, demographic, and clinical factors, but it is unknown whether the importance, equilibrium, and prediction uncertainty of established pharmacogenetic predictors (VKO...
Is dose adjustment of dolutegravir necessary in Chinese adults living with HIV across different body weight levels? A population pharmacokinetics analysis [0.03%]
中国人不同体重水平中living with HIV患者使用多替拉韦是否需要调整剂量？基于人群药代动力学分析
Rui Chen,Renfang Zhang,Ya-Ru Xing et al.
Rui Chen et al.
Background: Dolutegravir (DTG) is an integrase strand transfer inhibitor indicated for human immunodeficiency virus (HIV) infection. Although intrinsic factors show no ethnic-specific impact on DTG pharmacokinetics, extri...
Effect of terlipressin on renal outcomes in patients with liver cirrhosis and ascites: a retrospective multicenter study [0.03%]
特利加压素对肝硬化腹水患者肾结局的影响：一项回顾性多中心研究
Yong He,Xianxian Zhang,Ting Wang et al.
Yong He et al.
Background: Terlipressin is recommended for the treatment of acute kidney injury (AKI) in cirrhotic patients, but its role in those with ascites but without AKI is unclear. ...
Treatment strategies for pulmonary arterial hypertension associated with adult congenital heart diseases [0.03%]
与成人先天性心脏病相关的肺动脉高压的治疗策略
Satoshi Akagi,Shingo Kasahara,Kentaro Ejiri et al.
Satoshi Akagi et al.
Introduction: The number of patients with adult congenital heart disease (ACHD) is gradually increasing worldwide due to advances in surgical techniques and pharmacological therapies. ACHD can lead to pulmonary arterial h...
Novel biomarkers driving treatment selection in metastatic castration-sensitive prostate cancer: fundamentals of personalized clinical decision making [0.03%]
转移性雄激素敏感性前列腺癌中的新型生物标志物驱动治疗选择：个性化临床决策的基本要素
Lilia Bardoscia,Federico Camilli,Luca Triggiani et al.
Lilia Bardoscia et al.
Introduction: Prostate cancer is well known to be androgen-dependent, with growth directly relying on the androgen receptor signaling pathway. In fact, androgen deprivation therapy, with or without Docetaxel and/or newer ...
Osteoarthritis and dementia: contrasting disorders driven by mutual pathways of autophagy, mTOR, GLP-1, AMPK, Wnt, and WISP1 [0.03%]
骨关节炎和痴呆：自噬、mTOR、GLP-1、AMPK、Wnt和WISP1相互途径驱动的对比疾病
Kenneth Maiese
Kenneth Maiese
Introduction: Increased global lifespan is paralleled by a rise in non-communicable diseases with osteoarthritis and dementia, including Alzheimer's disease, impacting all nations with severe disability, death, and financ...