Heather H C Lau,Nicholas R G Silver,Surabhi Mehra et al.
Heather H C Lau et al.
Conformationally distinct "strains" of α-synuclein aggregates are believed to contribute to the clinical and pathological diversity observed among synucleinopathies such as multiple system atrophy (MSA) and Parkinson's disease. Cases of MS...
Artificial intelligence-based 3D segmentation of tangle-associated TDP-43 in neurodegeneration [0.03%]
基于人工智能的神经退行性疾病相关Tau缠结TDP-43的三维分割技术
Gokhan Uruk,Hossam Youssef,Rodolfo G Gatto et al.
Gokhan Uruk et al.
TAR DNA-binding protein 43 (TDP-43) inclusions are often associated with hyperphosphorylated tau, thus neurofibrillary tangles as the hallmark of Alzheimer's disease (AD) and primary age-related tauopathy (PART). TDP-43 in AD is associated ...
Francesca S Vacca,Aaron Mochizuki,Smruti K Patel et al.
Francesca S Vacca et al.
Molecular heterogeneity and prognostic biomarkers in primary meningeal melanocytic tumors [0.03%]
原发性脑膜黑色素细胞肿瘤的分子异质性和预后生物标志物
Rosina Paterra,Monica Patanè,Anna Stroppa et al.
Rosina Paterra et al.
Primary meningeal melanocytic tumors (PMMTs) are rare neoplasms currently stratified by the World Health Organization (WHO) into three grades of malignancy based exclusively on histopathological criteria, while the prognostic significance o...
Brain metastasis-associated fibroblasts shape the tumour microenvironment to enhance cancer cell invasion [0.03%]
脑转移相关的成纤维细胞重塑肿瘤微环境以增强癌细胞侵袭性
Barbora Výmolová,Lucie Pfeiferová,Tadeáš Karel Smetana et al.
Barbora Výmolová et al.
Brain metastases (BrM) are a frequent and life-threatening complication of solid tumours, with lung cancer representing their most common source. While cancer-associated fibroblasts (CAFs) are well-established contributors to tumour progres...
A 30-year-old woman with progressive lower extremity sensory loss and weakness [0.03%]
进行性下肢感觉及力气减退的三十岁女性患者
Daniel W Griepp,Chia-Ming Lee,Jeffrey P Turnbull et al.
Daniel W Griepp et al.
The immunological landscape of the area postrema in neuromyelitis optica spectrum disorders [0.03%]
视神经脊髓炎谱系障碍患者的下延髓背外侧区免疫景观研究
Qian Yu,Yoshiki Takai,Naoya Yamazaki et al.
Qian Yu et al.
Patients suffering from aquaporin-4 antibody-positive neuromyelitis spectrum disorder may present with radically different types of lesions in the central nervous system. They may show large tissue destructive lesions, as typically seen in ...
A novel myopathy with autophagic vacuoles associated with biallelic variants in CLN8 [0.03%]
CLN8双等位基因变异相关的新发自噬小体肌病
Ulrika Lindgren,Carola Hedberg-Oldfors,Kittichate Visuttijai et al.
Ulrika Lindgren et al.
Autophagic vacuoles in muscle fibers are a characteristic finding in several muscle diseases and usually indicate perturbed lysosomal protein degradation. Some of these are associated with defects in proteins directly involved in autophagy ...
From patient to tumor organoid: Culture protocol choice controls glioblastoma tumor architecture and identity [0.03%]
从病人到肿瘤类器官：培养方案的选择控制胶质母细胞瘤的肿瘤结构和身份
Jana Slovackova,Ondrej Bernatik,Katarina Cimborova et al.
Jana Slovackova et al.
Patient-derived tumor organoids are widely used in cancer research, yet the biological impact of tissue processing during model generation remains unclear. Fragment-based and dissociation-based (DIS) approaches are commonly assumed to trade...
ALT phenotype assessment in IDH-mutant astrocytoma supports biologic consequence of ATRX missense mutations [0.03%]
IDH突变型星形细胞瘤中的ALT表型评估支持ATRX错义突变的生物学后果
Oguzhan O Kizilkaya,Kevin Y Zhang,Mohamed Sherief et al.
Oguzhan O Kizilkaya et al.
A meaningful subset of IDH-mutant astrocytoma harbors ATRX missense variants that retain ATRX IHC immunoreactivity yet exhibit functional ALT activation, supporting the biologic relevance of these missense mutations. ...