The immunological landscape of the area postrema in neuromyelitis optica spectrum disorders [0.03%]
视神经脊髓炎谱系障碍患者的下延髓背外侧区免疫景观研究
Qian Yu,Yoshiki Takai,Naoya Yamazaki et al.
Qian Yu et al.
Patients suffering from aquaporin-4 antibody-positive neuromyelitis spectrum disorder may present with radically different types of lesions in the central nervous system. They may show large tissue destructive lesions, as typically seen in ...
A novel myopathy with autophagic vacuoles associated with biallelic variants in CLN8 [0.03%]
CLN8双等位基因变异相关的新发自噬小体肌病
Ulrika Lindgren,Carola Hedberg-Oldfors,Kittichate Visuttijai et al.
Ulrika Lindgren et al.
Autophagic vacuoles in muscle fibers are a characteristic finding in several muscle diseases and usually indicate perturbed lysosomal protein degradation. Some of these are associated with defects in proteins directly involved in autophagy ...
From patient to tumor organoid: Culture protocol choice controls glioblastoma tumor architecture and identity [0.03%]
从病人到肿瘤类器官：培养方案的选择控制胶质母细胞瘤的肿瘤结构和身份
Jana Slovackova,Ondrej Bernatik,Katarina Cimborova et al.
Jana Slovackova et al.
Patient-derived tumor organoids are widely used in cancer research, yet the biological impact of tissue processing during model generation remains unclear. Fragment-based and dissociation-based (DIS) approaches are commonly assumed to trade...
ALT phenotype assessment in IDH-mutant astrocytoma supports biologic consequence of ATRX missense mutations [0.03%]
IDH突变型星形细胞瘤中的ALT表型评估支持ATRX错义突变的生物学后果
Oguzhan O Kizilkaya,Kevin Y Zhang,Mohamed Sherief et al.
Oguzhan O Kizilkaya et al.
A meaningful subset of IDH-mutant astrocytoma harbors ATRX missense variants that retain ATRX IHC immunoreactivity yet exhibit functional ALT activation, supporting the biologic relevance of these missense mutations. ...
Clinicopathological and molecular heterogeneity of amyloid-β in unnatural deaths under 70 years: A forensic autopsy-based study [0.03%]
基于法医尸检的阿尔茨海默病未自然死亡患者淀粉样蛋白-β的临床病理和分子异质性研究
Shojiro Ichimata,Yukiko Hata,Koji Yoshida et al.
Shojiro Ichimata et al.
This study investigated the clinicopathological characteristics and molecular spectrum of amyloid-beta (Aβ) in unnatural deaths among relatively young individuals with moderate-to-severe Aβ deposition, including cases of early-onset Alzhe...
Interlaboratory performance testing on EPIC v2.0 CNS tumor profiling demonstrates high reproducibility of tumor classification but reveals the need for harmonized copy number variation reporting [0.03%]
EPIC v2.0中枢神经系统肿瘤谱系的室间性能测试展现出高重复性但揭示了拷贝数变异一致性报告的必要性
Katrin Mauch-Mücke,Christin Siewert,Lora Dimitrova et al.
Katrin Mauch-Mücke et al.
BeadChip array-based DNA methylation profiling has been recognized by the World Health Organization (WHO) as a key diagnostic tool for brain tumor classification. While its diagnostic utility has been well established, data on technical rep...
Non-Alzheimer Aβ deposits in the human CNS: Implications with hypoxia and related conditions [0.03%]
非阿尔茨海默病Aβ沉积在人类中枢神经系统中的意义及其与缺氧和相关疾病的关系
Esma Karlovich,David S Priemer,Charles Harker Rhodes et al.
Esma Karlovich et al.
We recently reported the deposition of Aβ in the frontal cortex of individuals who died of acute coronavirus disease 2019 (COVID-19), or who did not have COVID-19 but had respiratory distress, or infants with severe cardiac malformations. ...
Distinctly altered TRPC3 and TRPC6 expression patterns in human Alzheimer's disease cortex and hippocampus [0.03%]
人阿尔茨海默病皮层和海马中TRPC3和TRPC6表达模式的改变
Xingyong Chen,Zhengjun Wang,Jiaxing Wang et al.
Xingyong Chen et al.
Calcium dysregulation is increasingly recognized as a convergent mechanism underlying neuronal vulnerability and glial overactivation in Alzheimer's disease (AD). Transient Receptor Potential Canonical (TRPC) channels are potential key modu...
Lewy bodies are surrounded by granulovacuolar degeneration bodies in dementia with Lewy bodies [0.03%]
路易体周围有空泡-颗粒变性体的存在 councill II型路易体型痴呆病理变化的新发现
Searlait Thom,Pawel Palmowski,Andrew Porter et al.
Searlait Thom et al.
Lewy bodies (LBs), composed primarily of aggregated α-synuclein (α-syn), are the pathological hallmark of Lewy body diseases, including Parkinson's disease, Parkinson's disease dementia and dementia with Lewy bodies (DLB). Despite their d...
Samuel López Muñoz,Alberto Berjón,Carlos Rodríguez Antolín et al.
Samuel López Muñoz et al.