Glycogen Synthase Kinase-3beta regulates Snail and beta-catenin during gastrin-induced migration of gastric cancer cells [0.03%]
胃泌素诱导的胃癌细胞迁移过程中GSK-3β调节Snail和β-catenin的作用机制研究
Prajna Mishra,Subramanian Senthivinayagam,Ajay Rana et al.
Prajna Mishra et al.
Background: The gastrointestinal peptide hormone gastrin is known to regulate various cellular processes including proliferation, migration and metastasis in gastrointestinal (GI) cells. The studies described here were un...
EGFR/Met association regulates EGFR TKI resistance in breast cancer [0.03%]
EGFR/c-Met相互作用调节乳腺癌中的EGFR TKI耐药性
Kelly L Mueller,Zeng-Quan Yang,Ramsi Haddad et al.
Kelly L Mueller et al.
Breast cancers show a lack of response to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), despite 30% of tumors expressing EGFR. The mechanism of this resistance is unknown; however, we have recently shown that Me...
A novel mechanism of cell growth regulation by Cell Cycle and Apoptosis Regulatory Protein (CARP)-1 [0.03%]
细胞周期及凋亡调节蛋白(CARP)-1调控细胞增殖的新机制研究
Yan Jiang,Vineshkumar T Puliyappadamba,Liyue Zhang et al.
Yan Jiang et al.
Background: CARP-1/CCAR1, a perinuclear phospho-protein, regulates signaling by adriamycin, steroids, or growth factors. However, intracellular events that regulate CARP-1-dependent cell growth are not fully understood. ...
Adenoviral oncoprotein E1B55K mediates colocalization of SSBP2 and PML in response to stress [0.03%]
腺病毒致癌蛋白E1B55K介导的响应压力下的SSBP2和PML的共定位
Helen B Fleisig,Hong Liang,Lalitha Nagarajan
Helen B Fleisig
Transient expression of adenoviral oncoprotein E1B55K in normal cells induces aggresome formation and sequestration of critical host proteins in aggresomes. Our previous studies reported that Sequence Specific Binding Protein 2 (SSBP2), a c...
Zinc release from thapsigargin/IP3-sensitive stores in cultured cortical neurons [0.03%]
佛斯卡林／IP3敏感性库锌离子的释放作用于培养皮层神经元中的研究
Christian J Stork,Yang V Li
Christian J Stork
Background: Changes in ionic concentration have a fundamental effect on numerous physiological processes. For example, IP3-gated thapsigargin sensitive intracellular calcium (Ca2+) storage provides a source of the ion for...
NSC109268 potentiates cisplatin-induced cell death in a p53-independent manner [0.03%]
NSC109268以p53独立的方式增强顺铂诱导的细胞死亡
Eswar Shankar,Chandreyi Basu,Brett Adkins et al.
Eswar Shankar et al.
Background: Ovarian cancer is the leading cause of death among gynecological cancers. Cisplatin is one of the most effective anticancer drugs used in the treatment of ovarian cancer. Development of resistance to cisplatin...
AKAR2-AKAP12 fusion protein "biosenses" dynamic phosphorylation and localization of a GPCR-based scaffold [0.03%]
AKAR2-AKAP12融合蛋白对基于GPCR的支架的动力学磷酸化和定位进行“生物感应”
Jiangchuan Tao,Hsien-Yu Wang,Craig C Malbon
Jiangchuan Tao
Background: The cAMP-dependent protein kinase A (PKA) plays a pivotal role in virtually all cells, there being a multitude of important target molecules that are substrates for PKA in cell signaling. The spatial-temporal ...
Genetic and functional characterization of putative Ras/Raf interaction inhibitors in C. elegans and mammalian cells [0.03%]
基于线虫和哺乳动物细胞中的Ras/Raf相互作用的候选抑制剂的遗传及功能表征
Vanessa González-Pérez,David J Reiner,Jamie K Alan et al.
Vanessa González-Pérez et al.
Background: Activation of the mammalian Ras-Raf-MEK-ERK MAPK signaling cascade promotes cellular proliferation, and activating Ras mutations are implicated in cancer onset and maintenance. This pathway, a therapeutic targ...
Rong Tao,Jun Gong,Xixi Luo et al.
Rong Tao et al.
Background: AMP-activated protein kinase (AMPK) is a fuel-sensing enzyme that is activated when cells experience energy deficiency and conversely suppressed in surfeit of energy supply. AMPK activation improves insulin se...
Molecular mechanism of regulation of OGG1: tuberin deficiency results in cytoplasmic redistribution of transcriptional factor NF-YA [0.03%]
8-氧鸟嘌呤-DNA糖基化酶1的分子调节机制：脆性X综合征蛋白的缺乏导致转录因子NF-YA的细胞质重新分布
Samy L Habib
Samy L Habib
The tuberous sclerosis complex (TSC) is caused by defects in one of two tumor suppressor genes, TSC-1 or TSC-2. TSC-2 gene encodes tuberin, a protein involved in the pathogenesis of kidney tumors, both angiomyolipomas and renal cell carcino...