Dishevelled-3 C-terminal His single amino acid repeats are obligate for Wnt5a activation of non-canonical signaling [0.03%]
卷曲蛋白-3C端单氨基酸重复的His残基是Wnt5a激活非经典信号通路的必要条件
Li Ma,Ying Wang,Craig C Malbon et al.
Li Ma et al.
Background: The Wnt non-canonical pathway (Wnt5a > Frizzled-2 > cyclic GMP phosphodiesterase/Ca2+-mobilization pathway regulates the activation of NF-AT) is mediated by three mammalian Dishevelleds (Dvl1, Dvl2, and Dvl3) ...
TLN-4601 suppresses growth and induces apoptosis of pancreatic carcinoma cells through inhibition of Ras-ERK MAPK signaling [0.03%]
TLN-4601通过抑制Ras-ERK MAPK信号传导来抑制胰腺癌细胞的生长和诱导凋亡
Paul M Campbell,Nadia Boufaied,James J Fiordalisi et al.
Paul M Campbell et al.
Background: TLN-4601 is a structurally novel farnesylated dibenzodiazepinone discovered using Thallion's proprietary DECIPHER® technology, a genomics and bioinformatics platform that predicts the chemical structures of s...
The adaptor protein SH2B1β reduces hydrogen peroxide-induced cell death in PC12 cells and hippocampal neurons [0.03%]
SH2B1β适配蛋白可减少PC12细胞和海马神经元内的H₂O₂诱导的细胞死亡
Wan-Chen Lu,Chien-Jen Chen,Hui-Chien Hsu et al.
Wan-Chen Lu et al.
Background: SH2B1β is a signaling adaptor protein that has been shown to promote neuronal differentiation in PC12 cells and is necessary for the survival of sympathetic neurons. However, the mechanism by which SH2B1β ma...
Chaperones contribute to G protein coupled receptor oligomerization, but do not participate in assembly of the G protein with the receptor signaling complex [0.03%]
伴侣蛋白参与G蛋白偶联受体寡聚化，但不参与与受体信号复合物的G蛋白组装
Maha M Hammad,Denis J Dupré
Maha M Hammad
Background: Previous studies have demonstrated that seven transmembrane receptors (7TM-Rs) can associate with various chaperones to control their maturation and export. It has been shown for a few years now that 7TM-Rs ca...
AMPK-induced activation of Akt by AICAR is mediated by IGF-1R dependent and independent mechanisms in acute lymphoblastic leukemia [0.03%]
AICAR通过IGF-1R依赖和非依赖机制诱导急性淋巴细胞白血病中的Akt活化
Gilles M Leclerc,Guy J Leclerc,Guilian Fu et al.
Gilles M Leclerc et al.
Background: Children with Acute Lymphoblastic Leukemia (ALL) diagnosed with resistant phenotypes and those who relapse have a dismal prognosis for cure. In search for novel treatment strategies, we identified the AMP acti...
The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transition [0.03%]
dietary flavonoids quercetin与epigallocathechin gallate (egcg)协同作用抑制前列腺癌干细胞特性、侵袭、迁移和上皮间质转化
Su-Ni Tang,Chandan Singh,Dara Nall et al.
Su-Ni Tang et al.
Background: Much attention has been recently focused on the role of cancer stem cells (CSCs) in the initiation and progression of solid malignancies. Since CSCs are able to proliferate and self-renew extensively due to th...
UV-B induced transcript accumulation of DAHP synthase in suspension-cultured Catharanthus roseus cells [0.03%]
紫外线B照射对夹竹桃悬浮培养细胞bskdo基因表达的影响
Shilpa Ramani,Nandadevi Patil,Chelliah Jayabaskaran
Shilpa Ramani
The enzyme 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase (EC 4.1.2.15) catalyzes the first committed step in the shikimate pathway of tryptophan synthesis, an important precursor for the production of terpenoid indole alkaloid...
Novel cis-trans interactions are involved in post-transcriptional regulation of cyclin-dependent kinase inhibitor p21WAF1/CIP1 mRNA [0.03%]
新的顺式-反式相互作用参与了cyclin依赖性蛋白激酶抑制物p21WAF1/CIP1的mRNA的转录后调控
Liyue Zhang,Anil Wali,Joseph A Fontana et al.
Liyue Zhang et al.
Background: A variety of pathways target CDKI p21WAF1/CIP1 expression at transcriptional, post-transcriptional as well as translational levels. We previously found that cell growth suppressing retinoid CD437 enhanced expr...
Transformation by a nucleotide-activated P2Y receptor is mediated by activation of Galphai, Galphaq and Rho-dependent signaling pathways [0.03%]
核苷酸激活的P2Y受体通过活化Galphai、Galphaq及Rho依赖性信号转导通路介导反应形式的转换
Anurag Singh,José L Boyer,Channing J Der et al.
Anurag Singh et al.
Background: Nucleotide-actived P2Y receptors play critical roles in the growth of tumor cells by regulating cellular proliferation, differentiation and survival. ...
Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer [0.03%]
PI3K/AKT和MAPK/ERK信号通路的抑制导致胰腺癌中FOXO转录因子活化、细胞周期停滞及凋亡
Sanjit K Roy,Rakesh K Srivastava,Sharmila Shankar
Sanjit K Roy
Background: Mammalian forkhead members of the class O (FOXO) transcription factors, including FOXO1, FOXO3a, and FOXO4, are implicated in the regulation of several biological processes, including the stress resistance, me...