Heterodimerization of β2 adrenergic receptor and somatostatin receptor 5: Implications in modulation of signaling pathway [0.03%]
β₂肾上腺素受体与生长抑素受体5的异二聚化及其对信号转导途径的影响研究
Rishi K Somvanshi,Nicole Chaudhari,Xiaofan Qiu et al.
Rishi K Somvanshi et al.
Background: In the present study, we describe heterodimerization between human-Somatostatin Receptor 5 (hSSTR5) and β2-Adrenergic Receptor (β2AR) and its impact on the receptor trafficking, coupling to adenylyl cyclase ...
Shujuan Gao,Hsien-Yu Wang,Craig C Malbon
Shujuan Gao
Background: The family of A-kinase-anchoring proteins, AKAPs, constitutes a group of molecular scaffolds that act to catalyze dynamic interactions of protein kinase A, protein kinase C, tyrosine kinases, G-protein-coupled...
Combination of dasatinib and curcumin eliminates chemo-resistant colon cancer cells [0.03%]
达沙替尼和姜黄素的联合应用可清除化疗耐药的结肠癌细胞
Jyoti Nautiyal,Shailender S Kanwar,Yingjie Yu et al.
Jyoti Nautiyal et al.
Metastatic colorectal cancer remains a serious health concern with poor patient survival. Although 5-Fluorouracil (5-FU) or 5-FU plus oxaliplatin (FOLFOX) is the standard therapy for colorectal cancer, it has met with limited success. Recur...
Rad6B acts downstream of Wnt signaling to stabilize β-catenin: Implications for a novel Wnt/β-catenin target [0.03%]
Rad6B作为Wnt信号的下游稳定β-catenin的作用机制及对新的Wnt/β-catenin靶基因的启示
Brigitte Gerard,Larry Tait,Pratima Nangia-Makker et al.
Brigitte Gerard et al.
Background: Aberrant Wnt/β-catenin signaling is associated with breast cancer even though genetic mutations in Wnt signaling components are rare. We have previously demonstrated that Rad6B, an ubiquitin conjugating enzym...
Dual function of polycomb group proteins in differentiated murine T helper (CD4+) cells [0.03%]
多梳蛋白在分化的小鼠T辅助（CD4+）细胞中的双重功能
Eyal Jacob,Reut Hod-Dvorai,Or Lea Ben-Mordechai et al.
Eyal Jacob et al.
Background: Following antigen recognition, naive T helper (Th; CD4+) cells can differentiate toward one of several effector lineages such as Th1 and Th2; each expressing distinctive transcriptional profiles of cytokine ge...
Distinct roles of MK2 and MK5 in cAMP/PKA- and stress/p38MAPK-induced heat shock protein 27 phosphorylation [0.03%]
cAMP/PKA和胁迫/p38 MAPK诱导的热休克蛋白27磷酸化中MK2和MK5的不同作用
Alexey Shiryaev,Gianina Dumitriu,Ugo Moens
Alexey Shiryaev
Background: Classical mammalian mitogen-activated protein kinase (MAPK) pathways consist of a cascade of three successive phosphorylation events resulting in the phosphorylation of a variety of substrates, including anoth...
Shujuan Gao,Hsien-Yu Wang,Craig C Malbon
Shujuan Gao
Background: A-kinase-anchoring proteins, AKAPs, constitute a family of scaffolds that play an essential role in catalyzing the spatial-temporal, dynamic interactions of protein kinase A, protein kinase C, tyrosine kinases...
Activation of K-RAS by co-mutation of codons 19 and 20 is transforming [0.03%]
K-RAS密码子19和20的复合突变具有致瘤性
Adam Naguib,Catherine H Wilson,David J Adams et al.
Adam Naguib et al.
The K-RAS oncogene is widely mutated in human cancers. Activating mutations in K-RAS give rise to constitutive signalling through the MAPK/ERK and PI3K/AKT pathways promoting increased cell division, reduced apoptosis and transformation. Th...
Hsien-Yu Wang,Craig C Malbon
Hsien-Yu Wang
Background: Recent advances in our understanding of cell signaling have revealed assemblies of signaling components often viewed in fluorescence microscopy as very large, irregular "punctae". These punctae are often dynam...
Peroxisome proliferator-activated receptor gamma ligand-mediated apoptosis of hepatocellular carcinoma cells depends upon modulation of PI3Kinase pathway independent of Akt [0.03%]
过氧化物酶体增殖激活受体γ配体介导的肝癌细胞凋亡依赖于PI3K信号转导通路的调节独立于Akt的作用
Prajna Mishra,Suresh K Paramasivam,Ramesh P Thylur et al.
Prajna Mishra et al.
Background: Ligands of Peroxisome proliferator-activated receptor gamma (PPARγ) can inhibit growth and promote apoptosis in various cancer cells, and thus have the potential to be utilized as anticancer drugs. This poten...