Chibby suppresses growth of human SW480 colon adenocarcinoma cells through inhibition of β-catenin signaling [0.03%]
Cibby通过抑制β-连环蛋白信号传导来抑制人类SW480结肠腺癌细胞的生长
Victoria Fischer,Dex-Ann Brown-Grant,Feng-Qian Li
Victoria Fischer
The canonical Wnt signaling pathway is crucial for embryonic development and adult tissue homeostasis. Activating mutations in the Wnt pathway are frequently associated with the pathogenesis of various types of cancer, particularly colon ca...
Coexpression of human somatostatin receptor-2 (SSTR2) and SSTR3 modulates antiproliferative signaling and apoptosis [0.03%]
人源生长抑素受体-2（SSTR2）和SSTR3的共表达调节抗增殖信号传导和凋亡
Sajad A War,Ujendra Kumar
Sajad A War
Background: Somatostatin (SST) via five Gi coupled receptors namely SSTR1-5 is known to inhibit cell proliferation by cytostatic and cytotoxic mechanisms. Heterodimerization plays a crucial role in modulating the signal t...
"Shaping" of cell signaling via AKAP-tethered PDE4D: Probing with AKAR2-AKAP5 biosensor [0.03%]
通过AKAP锚定的PDE4D调节细胞信号转导的“塑形”现象——用AKAR2/AKAP5生物传感器探索之
Salih S Koçer,Hsien-Yu Wang,Craig C Malbon
Salih S Koçer
Background: PKA, a key regulator of cell signaling, phosphorylates a diverse and important array of target molecules and is spatially docked to members of the A-kinase Anchoring Protein (AKAP) family. AKAR2 is a biosensor...
The Caenorhabditis elegans D2-like dopamine receptor DOP-2 physically interacts with GPA-14, a Gαi subunit [0.03%]
一种D2类多巴胺受体DOP-2与G蛋白Gαi亚基GPA-14相互作用
Pratima Pandey,Singh Harbinder
Pratima Pandey
Dopaminergic inputs are sensed on the cell surface by the seven-transmembrane dopamine receptors that belong to a superfamily of G-protein-coupled receptors (GPCRs). Dopamine receptors are classified as D1-like or D2-like receptors based on...
Brain-derived neurotrophic factor receptor TrkB exists as a preformed dimer in living cells [0.03%]
脑源性神经营养因子受体TrkB以预形成二聚体存在于活细胞中
Jianying Shen,Ichiro N Maruyama
Jianying Shen
Background: Neurotrophins (NTs) and their receptors play crucial roles in the development, functions and maintenance of nervous systems. It is widely believed that NT-induced dimerization of the receptors initiates the tr...
Stephen McManus,Sophie Roux
Stephen McManus
Paget's disease of bone (PDB) is a skeletal disorder characterized by focal and disorganized increases in bone turnover and overactive osteoclasts. The discovery of mutations in the SQSTM1/p62 gene in numerous patients has identified protei...
E4BP4 facilitates glucocorticoid-evoked apoptosis of human leukemic CEM cells via upregulation of Bim [0.03%]
E4BP4通过上调Bim促进糖皮质激素诱发的人类急性淋巴细胞白血病CEM细胞凋亡
Jessica A Beach,Laura J Nary,Yasuko Hirakawa et al.
Jessica A Beach et al.
Background: Synthetic GCs serve as therapeutic agents for some lymphoid leukemias because of their ability to induce transcriptional changes via the GC receptor (GR) and trigger apoptosis. Upregulation of the BH3-only mem...
Canonical Wnt signaling is involved in switching from cell proliferation to myogenic differentiation of mouse myoblast cells [0.03%]
canonical Wnt信号通路参与调控小鼠肌管细胞增殖向分化的转换
Shingo Tanaka,Kumiko Terada,Tsutomu Nohno
Shingo Tanaka
Background: Wnt/β-catenin signaling is involved in various aspects of skeletal muscle development and regeneration. In addition, Wnt3a and β-catenin are required for muscle-specific gene transcription in embryonic carci...
Characterization of the Rac guanine nucleotide exchange factor P-Rex1 in platelets [0.03%]
血小板中嘌呤核苷酸交换因子P-Rex1的特征分析
Joseph E Aslan,Alex M Spencer,Cassandra P Loren et al.
Joseph E Aslan et al.
Background: Blood platelets undergo a carefully regulated change in shape to serve as the primary mediators of hemostasis and thrombosis. These processes manifest through platelet spreading and aggregation and are depende...
G-patch domain and KOW motifs-containing protein, GPKOW; a nuclear RNA-binding protein regulated by protein kinase A [0.03%]
含有G-补丁结构域和KOW模体的GPKOW；一种由蛋白激酶A调节的核RNA结合蛋白
Anne Kristin Aksaas,Anja Cv Larsen,Marie Rogne et al.
Anne Kristin Aksaas et al.
Background: Post-transcriptional processing of pre-mRNA takes place in several steps and requires involvement of a number of RNA-binding proteins. How pre-mRNA processing is regulated is in large enigmatic. The catalytic ...