Defining regulatory and phosphoinositide-binding sites in the human WIPI-1 β-propeller responsible for autophagosomal membrane localization downstream of mTORC1 inhibition [0.03%]
人类WIPI-1β翼状轮的调节和磷脂酰肌醇结合位点的定义，该蛋白在mTORC1抑制后的自噬溶酶体膜定位过程中发挥作用
Anja Gaugel,Daniela Bakula,Anneliese Hoffmann et al.
Anja Gaugel et al.
Background: Autophagy is a cytoprotective, lysosomal degradation system regulated upon induced phosphatidylinositol 3-phosphate (PtdIns(3)P) generation by phosphatidylinositol 3-kinase class III (PtdIns3KC3) downstream of...
NADPH oxidase mediates the oxygen-glucose deprivation/reperfusion-induced increase in the tyrosine phosphorylation of the N-methyl-D-aspartate receptor NR2A subunit in retinoic acid differentiated SH-SY5Y Cells [0.03%]
NADPH氧化酶介导视黄酸诱导的SH-SY5Y细胞中氧和葡萄糖剥夺/再灌注引起的N-甲基-D-天冬氨酸受体NR2A亚单位酪氨酸磷酸化的增加
Phillip H Beske,Darrell A Jackson
Phillip H Beske
Background: Evidence exists that oxidative stress promotes the tyrosine phosphorylation of N-methyl-D-aspartate receptor (NMDAR) subunits during post-ischemic reperfusion of brain tissue. Increased tyrosine phosphorylatio...
The roles played by highly truncated splice variants of G protein-coupled receptors [0.03%]
G蛋白偶联受体高度截短剪接变体的作用
Helen Wise
Helen Wise
Alternative splicing of G protein-coupled receptor (GPCR) genes greatly increases the total number of receptor isoforms which may be expressed in a cell-dependent and time-dependent manner. This increased diversity of cell signaling options...
Multiple biomarker tissue arrays: A computational approach to identifying protein-protein interactions in the EGFR/ERK signalling pathway [0.03%]
多重生物标志组织阵列：识别EGFR / ERK信号传导途径中蛋白质-蛋白质相互作用的计算方法
V Medina Villaamil,G Aparicio Gallego,M Valladares-Ayerbes et al.
V Medina Villaamil et al.
Background: Many studies have demonstrated genetic and environmental factors that lead to renal cell carcinoma (RCC) and that occur during a protracted period of tumourigenesis. It appears suitable to identify and charact...
Understanding sensitivity to BH3 mimetics: ABT-737 as a case study to foresee the complexities of personalized medicine [0.03%]
理解对BH3模体敏感性：ABT-737作为预知精准医疗复杂性的案例研究
Vasileios A Stamelos,Charles W Redman,Alan Richardson
Vasileios A Stamelos
BH3 mimetics such as ABT-737 and navitoclax bind to the BCL-2 family of proteins and induce apoptosis through the intrinsic apoptosis pathway. There is considerable variability in the sensitivity of different cells to these drugs. Understan...
Sanchita Roy,Adhip Pn Majumdar
Sanchita Roy
: Colorectal cancer is the fourth most common form of cancer worldwide and ranks third among the cancer-related deaths in the US and other Western countries. It occurs with equal frequency in men and women, constituting 10% of new cancer ca...
siRNA knockdown of GPR18 receptors in BV-2 microglia attenuates N-arachidonoyl glycine-induced cell migration [0.03%]
BV-2微胶质细胞中GPR18受体的siRNA敲除减弱了N-花生四烯酸甘氨酸诱导的细胞迁移作用
Douglas McHugh,James Wager-Miller,Jeremy Page et al.
Douglas McHugh et al.
Background: Neurons are known to employ the endogenous cannabinoid system to communicate with other cells of the CNS. Endocannabioid signaling recruits microglia toward neurons by engaging cannabinoid CB2 and abnormal can...
Tumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5 [0.03%]
非典型MAP激酶信号通路ERK3/4-MK5的促癌与抑癌作用
Sergiy Kostenko,Gianina Dumitriu,Ugo Moens
Sergiy Kostenko
Perturbed action of signal transduction pathways, including the mitogen-activated protein (MAP) kinase pathways, is one of the hallmarks of many cancers. While the implication of the typical MAP kinase pathways ERK1/2-MEK1/2, p38MAPK and JN...
Assembly of Dishevelled 3-based supermolecular complexes via phosphorylation and Axin [0.03%]
Dishevelled 3通过磷酸化和Axin组装多功能超级分子复合物
Noriko Yokoyama,Nelli G Markova,Hsien-Yu Wang et al.
Noriko Yokoyama et al.
Background: Dishevelled-3 (Dvl3) is a multivalent scaffold essential to cell signaling in development. Dsh/Dvls enable a myriad of protein-protein interactions in Wnt signaling. In the canonical Wnt/β-catenin pathway spe...
Akt (protein kinase B) isoform phosphorylation and signaling downstream of mTOR (mammalian target of rapamycin) in denervated atrophic and hypertrophic mouse skeletal muscle [0.03%]
Akt（蛋白激酶B）异构体的磷酸化及下游mTOR（哺乳动物雷帕霉素靶点）信号在去神经萎缩和肥大小鼠骨骼肌中的作用
Marlene Norrby,Kim Evertsson,Ann-Kristin Fjällström et al.
Marlene Norrby et al.
Background: The present study examines the hypothesis that Akt (protein kinase B)/mTOR (mammalian target of rapamycin) signaling is increased in hypertrophic and decreased in atrophic denervated muscle. Protein expression...