Identification of endoglin-dependent BMP-2-induced genes in the murine periodontal ligament cell line PDL-L2 [0.03%]
在小鼠牙周韧带细胞系PDL-L2中鉴定内皮素依赖的BMP-2诱导基因
Osamu Ishibashi,Takashi Inui
Osamu Ishibashi
Background: The periodontal ligament (PDL), connective tissue located between the cementum of teeth and alveolar bone of the mandibula, plays an important role in the maintenance and regeneration of periodontal tissues. W...
The metastasis suppressor Nm23 as a modulator of Ras/ERK signaling [0.03%]
Nm23转移抑制蛋白对Ras/ERK信号传导的调节作用
Krisztina Takács-Vellai
Krisztina Takács-Vellai
NM23-H1 (also known as NME1) was the first identified metastasis suppressor, which displays a nucleoside diphosphate kinase (NDPK) and histidine protein kinase activity. NDPKs are linked to many processes, such as cell migration, proliferat...
Probing the stoichiometry of β2-adrenergic receptor phosphorylation by targeted mass spectrometry [0.03%]
运用靶向质谱技术探讨β2肾上腺素受体磷酸化的化学计量学
Shujuan Gao,Craig Malbon,Hsien-Yu Wang
Shujuan Gao
Background: Protein phosphorylation of G-protein-coupled receptors (GPCR) is central to the myriad of functions that these ubiquitous receptors perform in biology. Although readily addressable with the use of phospho-spec...
p38 mitogen-activated protein kinase and mitogen-activated protein kinase-activated protein kinase 2 (MK2) signaling in atrophic and hypertrophic denervated mouse skeletal muscle [0.03%]
失神经小鼠骨骼肌萎缩和肥大P38丝裂原活化蛋白激酶和丝裂原活化蛋白激酶激活的蛋白激酶2(MK2)信号通路的研究
Kim Evertsson,Ann-Kristin Fjällström,Marlene Norrby et al.
Kim Evertsson et al.
Background: p38 mitogen-activated protein kinase has been implicated in both skeletal muscle atrophy and hypertrophy. T317 phosphorylation of the p38 substrate mitogen-activated protein kinase-activated protein kinase 2 (...
Kenji Watari,Michio Nakaya,Hitoshi Kurose
Kenji Watari
Desensitization is a physiological feedback mechanism that blocks detrimental effects of persistent stimulation. G protein-coupled receptor kinase 2 (GRK2) was originally identified as the kinase that mediates G protein-coupled receptor (GP...
Molecular targets and signaling pathways regulated by interleukin (IL)-24 in mediating its antitumor activities [0.03%]
视黄酸诱导基因Interleukin-24介导抗肿瘤作用的分子靶点及信号通路研究
Janani Panneerselvam,Anupama Munshi,Rajagopal Ramesh
Janani Panneerselvam
Cancer remains a major health issue in the world and the effectiveness of current therapies is limited resulting in disease recurrence and resistance to therapy. Therefore to overcome disease recurrence and have improved treatment efficacy ...
Chun-Hao Chen,Yen-Chih Chen,Hao-Ching Jiang et al.
Chun-Hao Chen et al.
The heterogeneity and multigenetic nature of nervous system aging make modeling of it a formidable task in mammalian species. The powerful genetics, simple anatomy and short life span of the nematode Caenorhabditis elegans offer unique adva...
A synergistic approach towards understanding the functional significance of dopamine receptor interactions [0.03%]
一种协同方法研究多巴胺受体相互作用的功能意义
Pratima Pandey,Mahlet D Mersha,Harbinder S Dhillon
Pratima Pandey
The importance of the neurotransmitter dopamine (DA) in the nervous system is underscored by its role in a wide variety of physiological and neural functions in both vertebrates and invertebrates. Binding of dopamine to its membrane recepto...
Membrane TNF-alpha-activated programmed necrosis is mediated by Ceramide-induced reactive oxygen species [0.03%]
由鞘氨醇诱导的反应性氧介导的膜TNF-α激活的程序性坏死
Shidrokh Ardestani,Desirae L Deskins,Pampee P Young
Shidrokh Ardestani
Background: Programmed necrosis is a form of caspase-independent cell death whose molecular regulation is poorly understood. While tumor necrosis factor-alpha (TNF-α) has been identified as an activator of programmed nec...
Mitochondrial H2O2 as an enable signal for triggering autophosphorylation of insulin receptor in neurons [0.03%]
线粒体H2O2作为触发神经元胰岛素受体自身磷酸化的信号分子作用机制研究
Nadezhda A Persiyantseva,Tatiana P Storozhevykh,Yana E Senilova et al.
Nadezhda A Persiyantseva et al.
Background: Insulin receptors are widely distributed in the brain, where they play roles in synaptic function, memory formation, and neuroprotection. Autophosphorylation of the receptor in response to insulin stimulation ...