Activator of G-protein Signaling 3 Controls Renal Epithelial Cell Survival and ERK5 Activation [0.03%]
G蛋白信号激活因子3调控肾上皮细胞存活和ERK5活化
Shauna A Rasmussen,Michelle Kwon,Jeffrey D Pressly et al.
Shauna A Rasmussen et al.
Activator of G-protein signaling 3 (AGS3) is an accessory protein that functions to regulate the activation status of heterotrimeric G-protein subunits. To date, however, the downstream signaling pathways regulated by AGS3 remain to be full...
The Intracellular Loop 2 F328S Frizzled-4 Mutation Implicated in Familial Exudative Vitreoretinopathy Impairs Dishevelled Recruitment [0.03%]
细胞内环2F328S Frizzled-4突变通过削弱与Dishevelled的相互作用损害信号转导以参与家族性渗出性玻璃体视网膜病变
Milly S Pau,Shujuan Gao,Craig C Malbon et al.
Milly S Pau et al.
Familial exudative vitreoretinopathy (FEVR) is a disease state characterized by aberrant retinal angiogenesis. Norrin-induced activation of Frizzled-4 (Fz4) has a major role in regulating beta-catenin levels in the eye that, in turn, modula...
Interaction with the Paxillin LD1 Motif Relieves MEKK2 Auto-inhibition [0.03%]
与Paxillin LD1基序的相互作用解除MEKK2自身抑制状态
Michael P Kahle,Bruce D Cuevas
Michael P Kahle
The cell signaling molecule MEK kinase 2 (MEKK2) is a key upstream regulator of MAPK activity that regulates numerous cellular functions, but the mechanisms that control MEKK2 activity are not well understood. Recently, we reported that MEK...
Mingda Yan,Ji Hee Ha,Danny N Dhanasekaran
Mingda Yan
The G12 family of heterotrimeric G proteins is defined by their α-subunits, Gα12 and Gα13. These α-subunits regulate cellular homeostasis, cell migration, and oncogenesis in a context-specific manner primarily through their interactions...
Inhibition of Gαs/cAMP Signaling Decreases TCR-Stimulated IL-2 transcription in CD4(+) T Helper Cells [0.03%]
Gαs/cAMP信号传导抑制可降低CD4⁺T辅助细胞中TCR刺激的IL-2转录水平
Thomas R Hynes,Evan A Yost,Stacy M Yost et al.
Thomas R Hynes et al.
Background: The role of cAMP in regulating T cell activation and function has been controversial. cAMP is generally known as an immunosuppressant, but it is also required for generating optimal immune responses. As the ef...
Inhibition of G-Protein βγ Signaling Decreases Levels of Messenger RNAs Encoding Proinflammatory Cytokines in T Cell Receptor-Stimulated CD4(+) T Helper Cells [0.03%]
G蛋白βγ信号传导抑制剂可降低TCR活化CD4⁺T细胞中促炎症细胞因子的信使RNA水平
Thomas R Hynes,Evan A Yost,Cassandra M Hartle et al.
Thomas R Hynes et al.
Background: Inhibition of G-protein βγ (Gβγ) signaling was found previously to enhance T cell receptor (TCR)-stimulated increases in interleukin 2 (IL-2) mRNA in CD4(+) T helper cells, suggesting that Gβγ might be a...
Forkhead box O1 and muscle RING finger 1 protein expression in atrophic and hypertrophic denervated mouse skeletal muscle [0.03%]
FoxO1和MuRF1在去神经萎缩和肥大小鼠骨骼肌中的表达分布差异研究
Ann-Kristin Fjällström,Kim Evertsson,Marlene Norrby et al.
Ann-Kristin Fjällström et al.
Background: Forkhead box O (FoxO) transcription factors and E3 ubiquitin ligases such as Muscle RING finger 1 (MuRF1) are believed to participate in the regulation of skeletal muscle mass. The function of FoxO transcripti...
Seminal plasma induces the expression of IL-1α in normal and neoplastic cervical cells via EP2/EGFR/PI3K/AKT pathway [0.03%]
精浆通过EP2/EGFR/PI3K/AKT途径诱导正常和肿瘤宫颈细胞中IL-1α的表达
Anthonio O Adefuye,Kurt J Sales,Arieh A Katz
Anthonio O Adefuye
Background: Cervical cancer is a chronic inflammatory disease of multifactorial etiology usually presenting in sexually active women. Exposure of neoplastic cervical epithelial cells to seminal plasma (SP) has been shown ...
Edith Yuk Ting Tse,Yick Pang Ching
Edith Yuk Ting Tse
The p21-activated kinases (PAKs) are downstream effectors of the Rho family small GTPases as well as a wide variety of mitogenic factors and have been implicated in cancer formation, development and metastasis. PAKs phosphorylate a wide spe...
Breast cancer cell invasion mediated by Gα12 signaling involves expression of interleukins-6 and -8, and matrix metalloproteinase-2 [0.03%]
Gα12信号转导介导的乳腺癌细胞侵袭与白细胞介素-6、-8表达及基质金属蛋白酶-2活性有关
Crystal Y Chia,Udhaya Kumari,Patrick J Casey
Crystal Y Chia
Background: Recent studies on the involvement of the G12 family of heterotrimeric G proteins (Gα12 and Gα13, the products of the GNA12 and GNA13 genes, respectively) in oncogenic pathways have uncovered a link between G...