Curcumin enhances the apoptosis-inducing potential of TRAIL in prostate cancer cells: molecular mechanisms of apoptosis, migration and angiogenesis [0.03%]
姜黄素通过增强TRAIL诱导的前列腺癌细胞凋亡来抑制其迁移和新生血管生成的分子机制研究
Sharmila Shankar,Qinghe Chen,Krishna Sarva et al.
Sharmila Shankar et al.
Background: We have recently shown that curcumin (a diferuloylmethane) inhibits growth and induces apoptosis, and also demonstrated that TRAIL induces apoptosis by binding to specific cell surface death receptors in prost...
PI3 K/Akt/mTOR-mediated translational control regulates proliferation and differentiation of lineage-restricted RoSH stem cell lines [0.03%]
PI3 K／Akt／mTOR介导的翻译控制调节限制性多能干细胞系RoSH的增殖和分化
Jianwen Que,Qizhou Lian,Reida M El Oakley et al.
Jianwen Que et al.
Background: We have previously derived highly similar lineage-restricted stem cell lines, RoSH and E-RoSH cell lines from mouse embryos and CD9hi SSEA-1- differentiated mouse embryonic stem cells, respectively. These cell...
Ligand-dependent localization and intracellular stability of sigma-1 receptors in CHO-K1 cells [0.03%]
配体依赖的CHO-K1细胞中σ-1受体的定位和胞内稳定性研究
Timur A Mavlyutov,Arnold E Ruoho
Timur A Mavlyutov
Background: Sigma-1 receptors are involved in regulation of neuronal activities presumably through regulation of the activity of ion channels. Sigma-1 receptors also play a role in growth and metastasis of cancerous cells...
Sensitization of TRAIL-resistant LNCaP cells by resveratrol (3, 4', 5 tri-hydroxystilbene): molecular mechanisms and therapeutic potential [0.03%]
白藜芦醇诱导前列腺癌LNCaP细胞抵抗TRAIL敏化的作用机制及治疗潜力研究
Sharmila Shankar,Qinghe Chen,Imtiaz Siddiqui et al.
Sharmila Shankar et al.
Background: We have previously shown that prostate cancer LNCaP cells are resistant to TRAIL, and downregulation of PI-3K/Akt pathway by molecular and pharmacological means sensitizes cells to undergo apoptosis by TRAIL a...
Clusterin expression can be modulated by changes in TCF1-mediated Wnt signaling [0.03%]
TCF1介导的Wnt信号传导的变化可调节Clusterin的表达
Troels Schepeler,Francisco Mansilla,Lise L Christensen et al.
Troels Schepeler et al.
Background: Clusterin (CLU) is an enigmatic molecule associated with various physiological processes and disease states. Different modes of cellular stress lead to increased CLU levels, and additionally numerous growth fa...
Peter J Halbrooks,Ru Ding,John M Wozney et al.
Peter J Halbrooks et al.
Background: The repulsive guidance molecule (RGM) proteins, originally discovered for their roles in neuronal development, have been recently identified as co-receptors in the bone morphogenetic protein (BMP) signaling pa...
PNRC is a unique nuclear receptor coactivator that stimulates RNA polymerase III-dependent transcription [0.03%]
PNRC是一个独特的核受体共激活因子，可刺激RNA聚合酶III依赖型转录
Dujin Zhou,Shuping Zhong,Jing-Jing Ye et al.
Dujin Zhou et al.
Background: PNRC transcriptionally regulates a wide range of RNA polymerase (pol) II-transcribed genes by functioning as a nuclear receptor coactivator. To search for additional PNRC-interacting proteins other than nuclea...
Ian S Hagemann,Kirk D Narzinski,Thomas J Baranski
Ian S Hagemann
Background: Heterotrimeric G proteins are important for numerous signaling events in eukaryotes, serving primarily to transduce signals that are initiated by G protein-coupled receptors. It has recently become clear that ...
Molecular mechanisms mediating the G protein-coupled receptor regulation of cell cycle progression [0.03%]
介导G蛋白偶联受体调节细胞周期进程的分子机制
David C New,Yung H Wong
David C New
G protein-coupled receptors are key regulators of cellular communication, mediating the efficient coordination of a cell's responses to extracellular stimuli. When stimulated these receptors modulate the activity of a wide range of intracel...
ArhGAP9, a novel MAP kinase docking protein, inhibits Erk and p38 activation through WW domain binding [0.03%]
新的MAP激酶衔接蛋白ArhGAP9通过WW结构域结合抑制Erk和p38的活化
Boon K Ang,Chun Y Lim,Sharon S Koh et al.
Boon K Ang et al.
We have identified human ArhGAP9 as a novel MAP kinase docking protein that interacts with Erk2 and p38alpha through complementarily charged residues in the WW domain of ArhGAP9 and the CD domains of Erk2 and p38alpha. This interaction sequ...