Inhibition of PI3K/AKT and MEK/ERK pathways act synergistically to enhance antiangiogenic effects of EGCG through activation of FOXO transcription factor [0.03%]
PI3K/AKT和MEK/ERK途径的抑制协同增强EGCG的抗血管生成作用通过激活FOXO转录因子实现
Sharmila Shankar,Qinghe Chen,Rakesh K Srivastava
Sharmila Shankar
Background: We have recently shown that epigallocatechin-3-gallate (EGCG), a polyphenolic compound from green tea, inhibits angiogenesis. However, the molecular mechanisms by which EGCG inhibits angiogenesis have never be...
The alpha1D-adrenergic receptor is expressed intracellularly and coupled to increases in intracellular calcium and reactive oxygen species in human aortic smooth muscle cells [0.03%]
α1D-肾上腺素受体在人主动脉平滑肌细胞内表达并增加细胞内钙和活性氧水平
Mary L García-Cazarín,Jennifer L Smith,Kyle A Olszewski et al.
Mary L García-Cazarín et al.
Background: The cellular localization of the alpha1D-adrenergic receptor (alpha1D-AR) is controversial. Studies in heterologous cell systems have shown that this receptor is expressed in intracellular compartments. Other ...
Binding mode prediction of conformationally restricted anandamide analogs within the CB1 receptor [0.03%]
构象限制型AEA类似物在CB1受体内的结合模式预测
Lea W Padgett,Allyn C Howlett,Joong-Youn Shim
Lea W Padgett
Background: CB1 cannabinoid receptors are G-protein coupled receptors for endocannabinoids including anandamide and 2-arachidonoylglycerol. Because these arachidonic acid metabolites possess a 20-carbon polyene chain as t...
Dramatic inhibition of osteoclast sealing ring formation and bone resorption in vitro by a WASP-peptide containing pTyr294 amino acid [0.03%]
含有pTyr294氨基酸的WASP肽对破骨细胞封圈形成及体外骨吸收的强烈抑制作用
Tao Ma,Venkatesababa Samanna,Meenakshi A Chellaiah
Tao Ma
Wiskott Aldrich Syndrome protein (WASP) has a unique regulatory role in sealing ring formation and bone resorption in osteoclasts. Here, using the TAT-transduction method, we show the possible role of WASP domain(s) in sealing ring formatio...
Retinoic acid decreases ATF-2 phosphorylation and sensitizes melanoma cells to taxol-mediated growth inhibition [0.03%]
视黄酸降低ATF-2磷酸化并使黑素瘤细胞对Taxol介导的生长抑制产生敏感性
Ying Huang,Jennifer Minigh,Sarah Miles et al.
Ying Huang et al.
Cutaneous melanoma is often resistant to chemo- and radiotherapy. This resistance has recently been demonstrated to be due, at least in part, to high activating transcription factor 2 (ATF-2) activity in these tumors. In concordance with th...
Association of TRAF2 with the short form of cellular FLICE-like inhibitory protein prevents TNFR1-mediated apoptosis [0.03%]
TRAF2与细胞FLIP短形式的关联可防止TNFR1介导的细胞凋亡
Dong-Joon Kim,Chan Park,Bermseok Oh et al.
Dong-Joon Kim et al.
Background: We have previously shown that c-FLIPL is a more potent inhibitor than c-FLIPS of Fas ligand-induced apoptosis and that c-FLIPL physically binds to Daxx, an alternative Fas-signaling adaptor. Here we examined w...
Danielle M Scheswohl,Jessica R Harrell,Zenon Rajfur et al.
Danielle M Scheswohl et al.
Background: FAK localization to focal adhesions is essential for its activation and function. Localization of FAK is mediated through the C-terminal focal adhesion targeting (FAT) domain. Recent structural analyses have r...
Alexandra V Andreeva,Mikhail A Kutuzov,Tatyana A Voyno-Yasenetskaya
Alexandra V Andreeva
Heterotrimeric G proteins are ubiquitous signaling partners of seven transmembrane-domain G-protein-coupled receptors (GPCRs), the largest (and most important pharmacologically) receptor family in mammals. A number of scaffolding proteins h...
Phosphoprotein phosphatase-2A docks to Dishevelled and counterregulates Wnt3a/beta-catenin signaling [0.03%]
蛋白磷酸酶2A与Dsh相互作用并调节Wnt3a/β链锁信号通路
Noriko Yokoyama,Craig C Malbon
Noriko Yokoyama
Background: Wnt3a stimulates cellular trafficking of key signaling elements (e.g., Axin, Dishevelled-2, beta-catenin, and glycogen synthase kinase-3beta) and primitive endoderm formation in mouse F9 embryonic teratocarcin...
Abundance, complexation, and trafficking of Wnt/beta-catenin signaling elements in response to Wnt3a [0.03%]
Wnt3a诱导的Wnt/β-catenin信号分子的丰度、复合物形成及转运现象分析
Noriko Yokoyama,Dezhong Yin,Craig C Malbon
Noriko Yokoyama
Background: Wnt3a regulates a canonical signaling pathway in early development that controls the nuclear accumulation of beta-catenin and its activation of Lef/Tcf-sensitive transcription of developmentally important gene...