Immature and mature species of the human Prostacyclin Receptor are ubiquitinated and targeted to the 26S proteasomal or lysosomal degradation pathways, respectively [0.03%]
人前列腺素I2受体的未成熟和成熟形式分别被泛素标记并进入蛋白酶体或溶酶体降解途径
Peter D Donnellan,B Therese Kinsella
Peter D Donnellan
Background: The human prostacyclin receptor (hIP) undergoes agonist-induced phosphorylation, desensitisation and internalisation and may be recycled to the plasma membrane or targeted for degradation by, as yet, unknown m...
Glucocorticoid evoked upregulation of RCAN1-1 in human leukemic CEM cells susceptible to apoptosis [0.03%]
糖皮质激素上调人类白血病CEM细胞中RCAN1-1的表达与促凋亡作用的关系研究
Yasuko Hirakawa,Laura J Nary,Rheem D Medh
Yasuko Hirakawa
Background: Glucocorticoid hormones (GCs) induce apoptosis of leukemic T-cells by transcriptional regulation via the GC receptor, GR. In the human leukemic CEM cell culture model, RCAN1 has been identified as one of the g...
Romidepsin inhibits Ras-dependent growth transformation of NIH 3T3 fibroblasts and RIE-1 epithelial cells independently of Ras signaling inhibition [0.03%]
Romidepsin独立于Ras信号抑制抑制NIH 3T3成纤维细胞和RIE-1上皮细胞的Ras依赖性增殖转化
Ariella B Hanker,Kevin D Healy,Jean Nichols et al.
Ariella B Hanker et al.
Background: Despite intensive effort, currently no effective anti-Ras therapies have successfully reached clinical application. Previous studies suggest that the histone deacetylatse (HDAC) inhibitor romidepsin, which is ...
Overexpression of tissue inhibitors of metalloproteinase 2 up-regulates NF-kappaB activity in melanoma cells [0.03%]
组织金属蛋白酶抑制因子-2在黑色素瘤细胞中的高表达上调NF-κB活性
Jun Sun,William G Stetler-Stevenson
Jun Sun
Background: Matrix Metalloproteinase functions in the remodeling of the extracellular matrix that is integral for many normal and pathological processes such as morphogenesis, angiogenesis, tissue repair, and tumor invasi...
Expression analyses of nuclear receptor genes in breast cancer cell lines exposed to soy phytoestrogens after BRCA2 knockdown by TaqMan Low-Density Array (TLDA) [0.03%]
BRCA2敲低后TaqMan低密度阵列分析大豆植物雌激素诱导的乳腺癌细胞系中核受体基因表达变化
Samir Satih,Hélène Savinel,Nadège Rabiau et al.
Samir Satih et al.
Background: Most of breast cancers are considered sporadic and modulation of the two major genes BRCA1 and BRCA2 expressions caused by tissue-specific somatic mutations lead to this pathology. The nutritional intake of ph...
Membrane estrogen receptor-alpha-mediated nongenomic actions of phytoestrogens in GH3/B6/F10 pituitary tumor cells [0.03%]
植物雌激素在GH3/B6/F10垂体肿瘤细胞中膜雌激素受体-α介导的非基因组作用
Yow-Jiun Jeng,Mikhail Y Kochukov,Cheryl S Watson
Yow-Jiun Jeng
Background: Estradiol (E2) mediates various intracellular signaling cascades from the plasma membrane via several estrogen receptors (ERs). The pituitary is an estrogen-responsive tissue, and we have previously reported t...
AKT/eNOS signaling module functions as a potential feedback loop in the growth hormone signaling pathway [0.03%]
Akt/eNOS信号模块能作为潜在的反馈回路在生长激素信号传导途径中起作用
Cong-Jun Li,Theodore H Elsasser,Stanislaw Kahl
Cong-Jun Li
Background: While evidence suggested that the activity states of Protein kinase B (AKT/PKB) and endothelial nitric oxide synthase (eNOS) play an important role in the progression of the Growth Hormone (GH) signal cascade,...
Differential role of beta-arrestin ubiquitination in agonist-promoted down-regulation of M1 vs M2 muscarinic acetylcholine receptors [0.03%]
β-arrbane泛素化在激动剂诱导的M1和M2型胆碱能受体下调中的不同作用
Valerie A Mosser,Kymry T Jones,Katie M Hoffman et al.
Valerie A Mosser et al.
Background: Sustained agonist-promoted ubiquitination of beta-arrestin has been correlated with increased stability of the GPCR - beta-arrestin complex. Moreover, abrogation of beta-arrestin ubiquitination has been report...
G-protein-coupled receptor-associated A-kinase anchoring proteins AKAP5 and AKAP12: differential signaling to MAPK and GPCR recycling [0.03%]
G蛋白偶联受体相关A激酶锚定蛋白AKAP5和AKAP12：MAPK和GPCR循环的差别信号转导
Jiangchuan Tao,Craig C Malbon
Jiangchuan Tao
Background: A-kinase Anchoring Protein AKAP5 and AKAP12 both dock to the beta2-adrenergic receptor, the former constitutively, the latter dynamically in response to activation of the receptor with agonist. ...
Cell cycle arrest in Metformin treated breast cancer cells involves activation of AMPK, downregulation of cyclin D1, and requires p27Kip1 or p21Cip1 [0.03%]
二甲双胍诱导的乳腺癌细胞周期停滞涉及AMPK活化、cyclinD1下调以及p27kip1或p21cip1依赖性反应
Yongxian Zhuang,W Keith Miskimins
Yongxian Zhuang
Background: The antihyperglycemic drug metformin may have beneficial effects on the prevention and treatment of cancer. Metformin is known to activate AMP-activated protein kinase (AMPK). It has also been shown to inhibit...