Sex-specific epigenetic mediators between early life social disadvantage and adulthood BMI [0.03%]
生命早期社会不利因素通过表观遗传介质影响成人BMI的性别差异
Su H Chu,Eric B Loucks,Karl T Kelsey et al.
Su H Chu et al.
Aim: The objective of this study was to identify potential epigenetic mediating pathways linking early life social disadvantage (ELSD) to adulthood BMI. M...
miRNA-based strategy for modulation of influenza A virus infection [0.03%]
基于microRNA调节流感病毒A型病毒感染的新策略研究
Mohsen Keshavarz,Hassan Dianat-Moghadam,Vahideh Hamidi Sofiani et al.
Mohsen Keshavarz et al.
Influenza A virus is known worldwide as a threat associated with human and livestock diseases. Hence, identification of physiological and molecular aspects of influenza A could contribute to better design of therapeutic approaches for reduc...
Intergenerational effects of endocrine-disrupting compounds: a review of the Michigan polybrominated biphenyl registry [0.03%]
环境内分泌干扰物的跨世代效应-来自密歇根多溴联苯登记处的研究综述
Sarah W Curtis,Karen N Conneely,Mary E Marder et al.
Sarah W Curtis et al.
Endocrine-disrupting compounds (EDCs) are a broad class of chemicals present in many residential products that can disrupt hormone signaling and cause health problems in humans. Multigenerational cohorts, like the Michigan polybrominated bi...
Differentially expressed circulating microRNAs in the development of acute diabetic Charcot foot [0.03%]
急性糖尿病Charcot足病相关循环microRNA表达变化研究
Jennifer Pasquier,Vimal Ramachandran,Moh&#x;d Rasheed Abu-Qaoud et al.
Jennifer Pasquier et al.
Aim: Charcot foot (CF) is a rare complication of Type 2 diabetes (T2D). Materials & methods: We assessed circulating miRNAs in 17 patie...
Next generation sequencing for miRNA profile of spleen CD4+ T cells in the murine model of acute asthma [0.03%]
小鼠急性哮喘模型脾脏CD4+T细胞的miRNA测序分析
Ye Liu,Zhongqi Chen,Kun Xu et al.
Ye Liu et al.
Aim: To explore the miRNAs profile of CD4+ T lymphocytes in asthma via next generation sequencing. Methods: In the murine model of acut...
Histone acetylation maps in aged mice developmentally exposed to lead: epigenetic drift and Alzheimer-related genes [0.03%]
老年铅暴露小鼠的组蛋白乙酰化图谱：表观遗传漂变与阿尔茨海默病相关基因
Aseel Eid,Syed Waseem Bihaqi,Christopher Hemme et al.
Aseel Eid et al.
Aim: Early life exposure to lead (Pb) has been shown to increase late life biomarkers involved in Alzheimer's disease (AD) pathology. Here, we tested the hypothesis that latent over expression of AD-related genes may be r...
Enrichment of methylated molecules using enhanced-ice-co-amplification at lower denaturation temperature-PCR (E-ice-COLD-PCR) for the sensitive detection of disease-related hypermethylation [0.03%]
利用改进的低温变性pcr技术检测与疾病相关的高甲基化状态
Florence Mauger,Magali Kernaleguen,Céline Lallemand et al.
Florence Mauger et al.
Aim: The detection of specific DNA methylation patterns bears great promise as biomarker for personalized management of cancer patients. Co-amplification at lower denaturation temperature-PCR (COLD-PCR) assays are sensiti...
A novel cell-type deconvolution algorithm reveals substantial contamination by immune cells in saliva, buccal and cervix [0.03%]
一种新型细胞类型脱卷积算法揭示了免疫细胞在唾液、颊黏膜和宫颈中的大量污染
Shijie C Zheng,Amy P Webster,Danyue Dong et al.
Shijie C Zheng et al.
Aim: An outstanding challenge in epigenome studies is the estimation of cell-type proportions in complex epithelial tissues. Materials & methods: ...
Circular RNA PVT1 expression and its roles in acute lymphoblastic leukemia [0.03%]
圆RNA PVT1表达及其在急性淋巴细胞白血病中的作用
Jiaojiao Hu,Qi Han,Yan Gu et al.
Jiaojiao Hu et al.
Aim: The roles of circular RNA PVT1 (circPVT1) are explored in the patients with acute lymphoblastic leukemia (ALL). Methods: The circP...
Uncovering novel landscape of cardiovascular diseases and therapeutic targets for cardioprotection via long noncoding RNA-miRNA-mRNA axes [0.03%]
通过长链非编码RNA-miRNA-mRNA轴揭示心血管疾病的新型景观和心肌保护的治疗靶点
Liang He,Yan Chen,Shuqing Hao et al.
Liang He et al.
Protein coding sequences account for around 3% of the human genome, the rest are noncoding RNA (ncRNA) including long ncRNA (lncRNA) and miRNA. Accumulating evidence indicates that lncRNAs and miRNAs are candidate biomarkers for diagnosis, ...