Bala Gur Dedeoglu,Senem Noyan,Kübra Nur Kaplan İlhan
Bala Gur Dedeoglu
Breast cancer represents a molecularly heterogeneous disease shaped by complex genetic, epigenetic, and transcriptional dysregulation. Non-coding RNAs (ncRNAs) including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs ...
Mei Wu,Yuan Zhao,Shiyan Gu et al.
Mei Wu et al.
Sarcopenia is an age-associated degenerative disorder of skeletal muscle, characterized by the progressive decline in muscle mass and function, which increases the risk of falls, injuries, and accidental death in older adults. Deciphering i...
Assessing the epigenetic consequences of ART in male infertility: what risks to embryo and offspring health? [0.03%]
辅助生殖技术对男性不育的表观遗传影响评估：胚胎和后代健康的风险是什么？
Jorge Hallak,Thiago Afonso Teixeira,João Pedro M Gismondi et al.
Jorge Hallak et al.
Male infertility affects approximately 7 to 8% of men worldwide and is influenced by both genetic and epigenetic factors. Epigenetic mechanisms - including DNA methylation, histone modifications, and non-coding RNAs - are essential for sper...
Targeting epigenetic remodeling of the blood-brain barrier: current knowledge for drug therapy [0.03%]
针对血脑屏障表观遗传重塑的药物治疗研究最新进展
Maya Akhoury,Nicole Vegara,Svetlana M Stamatovic et al.
Maya Akhoury et al.
The blood - brain barrier (BBB) is a dynamic regulator of brain homeostasis, and its dysfunction is a hallmark of many neurological and psychiatric disorders. Yet, in most conditions, the causal relationship between BBB injury and disease p...
DNA methyltransferase inhibitors in oncology: clinical progress, limitations and future directions [0.03%]
肿瘤学中DNA甲基转移酶抑制剂的临床进展、局限性及未来方向
David C Michael,Parinaz Mehdipour
David C Michael
Over the past century, cancer therapy has evolved from broadly cytotoxic approaches to mechanism-based treatments. Recognition of epigenetic dysregulation as a cancer hallmark paved the way for epigenetic therapies. The earliest to gain U.S...
Epigenetic regulation in MASLD - insight for therapeutic target discovery [0.03%]
MASLD中的表观遗传调控与治疗靶点发现的新视野
Jan H Britsemmer,Nuria Lopez Alcantara,Henriette Kirchner
Jan H Britsemmer
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease. It encompasses metabolic affections that arise primarily from lifestyle and diet, independent of alcohol consumption. Particularly...
From research to clinical practice: DNA methylation signatures as diagnostic tools for Alzheimer's disease [0.03%]
从研究到临床实践：DNA甲基化标志物作为阿尔茨海默病的诊断工具
Nobuyoshi Shimoda
Nobuyoshi Shimoda
Based on their ability to analyze methylation differences genome-wide in a large number of samples at a reasonable cost and time, microarrays were rapidly adopted by Alzheimer's disease (AD) researchers to isolate CpG sites with methylation...
EpiSmokEr2: a robust epigenetic classifier for smoking status inference using Illumina EPIC methylation data [0.03%]
EpiSmokEr2：使用Illumina EPIC甲基化数据进行吸烟状态推断的鲁棒表观遗传分类器
Tianyu Zhu,Teodóra Faragó,Sailalitha Bollepalli et al.
Tianyu Zhu et al.
Aim: Tobacco smoking induces persistent DNA methylation (DNAm) changes in blood that can serve as long-term biomarkers for smoking exposure. We aimed to develop and validate a DNAm classifier of smoking status using Illum...
Mitochondrial D-loop region methylation differentiates Parkinson's disease from atypical parkinsonism and Parkinson's disease dementia [0.03%]
线粒体D-环区域甲基化区分帕金森病和非典型帕金森综合征及帕金森痴呆
Bilge Karacicek,Bilgesu Ozturk,Ozgur Oztop Cakmak et al.
Bilge Karacicek et al.
Background: Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by dopaminergic neuron loss and α-synuclein aggregation. Epigenetic mechanisms, including mitochondrial DNA (mtDNA) methylati...
Interaction of host genetic factor and gastric microbiome in DNA methylation induction [0.03%]
宿主遗传因素和胃肠道微生物组在DNA甲基化诱导中的相互作用
Tomomitsu Tahara,Tsubasa Shimogama,Takuya Shijimaya et al.
Tomomitsu Tahara et al.