Ultra-sensitive urine DNA methylation test enables early and accurate detection of bladder cancer [0.03%]
超灵敏的尿液DNA甲基化检测可早期准确发现膀胱癌
Zhichao Tong,Tianxi Yu,Zhilong Li et al.
Zhichao Tong et al.
Background: Early and accurate detection of bladder cancer (BCa), particularly low-grade and early-stage disease, remains challenging because current diagnostic methods are either invasive or insufficiently sensitive. We ...
Promoter methylation-associated brain-enriched long noncoding RNAs in glioblastoma: a multi-cohort public epigenomic re-analysis [0.03%]
胶质母细胞瘤中与启动子甲基化相关的脑丰富型长链非编码RNA：多队列公共表观基因组的重新分析
Ye Tan,Fengyu Cheng,Pu Li et al.
Ye Tan et al.
Background: Glioblastoma (GBM) is epigenetically heterogeneous, and previous long noncoding RNA (lncRNA) methylation studies have often begun from tumor-wide screens. We asked whether brain-enriched lncRNAs show promoter ...
Ulrich Lehmann
Ulrich Lehmann
Tumor suppressor genes and DNA repair genes can be inactivated not only by genetic lesions, like mutations or deletions, but also by aberrant DNA methylation of promoter regions. These DNA methylation alterations may serve as biomarkers for...
DNA methylation in glioblastoma: insights from single-cell epigenomics [0.03%]
单细胞表观基因组学揭示的弥漫性胶质瘤DNA甲基化特征
Rana Zohreh,Nima Rezaei,Parisa Amirifar
Rana Zohreh
Isocitrate dehydrogenase (IDH)-wildtype glioblastoma is an aggressive brain tumor characterized by limited therapeutic options and poor survival outcomes. Beyond well-established genomic alterations, epigenetic mechanisms such as DNA methyl...
Zhaoqi Shi,Mengting Jiang,Jian Chen et al.
Zhaoqi Shi et al.
The cell nucleus is a dynamic and mechanically active organelle whose physical properties significantly influence genome organization, gene regulation, and cellular identity. Over the past two decades, research has increasingly focused on t...
Transposable element regulation in mammalian germ cells and other contexts: multilayered repression, fertility, and regulated activation [0.03%]
哺乳动物生殖细胞和其他环境中的转座元件调控：多层次抑制、生育与激活调节
Peilin Li,Soichiro Yamanaka
Peilin Li
Transposable elements (TEs), particularly retrotransposons that dominate mammalian genomes, are pervasive components of mammalian genomes whose activation is constrained by multilayered repression systems. In germ cells, this repression arc...
Machine learning models predict the immunotherapy response in tumors on the basis of DNA methylation [0.03%]
基于DNA甲基化的机器学习模型预测肿瘤的免疫治疗反应
Zheng Gu,Ning Jiang,Erle Deng et al.
Zheng Gu et al.
Background: The epigenetic control of immune responses plays a crucial role in the development and progression of cancer. The need to identify biomarkers and create new predictive models is crucial to reliably estimate re...
Epigenetic reprogramming of tissue-resident memory T cells in chronic inflammatory disorders and implications for targeted therapies [0.03%]
慢性炎症性疾病中组织驻留记忆T细胞的表观遗传重编程及其对靶向治疗的意义
Chen Ling,Haytham F Isleem,Ghanshyam G Tejani
Chen Ling
Background: Tissue-resident memory T (TRM) cells play a role in causing long-term tissue injury in chronic inflammatory diseases via pathological epigenetic reprogramming. Nevertheless, the epigenetic processes that cause...
MicroRNA-510-3p alleviates endothelial dysfunction in a DOCA-salt rat model of hypertension by targeting phosphatase and tensin homolog and its signaling axis [0.03%]
microRNA-510-3p通过靶向磷脂和张力同源基因及其信号轴缓解高血压模型大鼠内皮功能障碍
K Auxzilia Preethi,Sushmaa Chandralekha Selvakumar,Thangavel Muthusamy et al.
K Auxzilia Preethi et al.
Essential hypertension, characterized by persistent elevation of blood pressure, is often associated with endothelial dysfunction (ED), marked by impaired endothelial activity. Despite advancements, the molecular mechanisms underlying ED in...
Epigenetic regulation of non-coding DNA in placental development and disorders [0.03%]
表观遗传学调控非编码DNA在胎盘发育及疾病中的作用
Ying Hei Kan,Lin Gao,Danny Leung
Ying Hei Kan
The human placenta is an epigenetically exceptional organ that must execute rapid proliferation, lineage bifurcation, and controlled invasion while maintaining immune tolerance at the maternal-fetal interface. Trophoblast lineages operate w...