MAGE-A in triple-negative breast cancer: molecular biology, epigenetic targeting, and immunotherapy [0.03%]
乳腺癌中的MAGE-A：分子生物学、表观遗传学靶向和免疫治疗
Nik Mohd Asri Nik Amirah Auni,Norhanani Mohd Redzwan,Faezahtul Arbaeyah Hussain et al.
Nik Mohd Asri Nik Amirah Auni et al.
The MAGE-A family consists of proteins with restricted expression profiles in normal tissues but expressed in multiple solid tumor types including triple-negative breast cancer (TNBC). In this review, we describe and discuss the potential o...
Genetic and epigenetic regulatory networks in atrioventricular block: mechanisms and therapeutic prospects [0.03%]
房室传导阻滞的遗传与表观遗传调控网络：机制及治疗前景
Song Yan,Yuting Xia,Jin Liu et al.
Song Yan et al.
Atrioventricular block (AVB) is a frequent arrhythmia and can arise from both genetic predisposition and epigenetic regulation. This review provides a synopsis of the latest findings concerning the interactions of genetic-epigenetic interac...
Association of DNA methylation and musculoskeletal spinal pain at four timepoints during adolescence and early adulthood [0.03%]
DNA甲基化与青少年及成年早期四个时间点的肌肉骨骼脊柱疼痛的相关性研究
Darren Beales,Robert Waller,Jasmine Yong Ning Chia et al.
Darren Beales et al.
Background: This study examined the association between epigenetic genome-wide DNA methylation with mechanism-based phenotypes of spinal pain from adolescence through early adulthood, accounting for confounders. ...
DNA methylation age acceleration mediates the relationship between systemic inflammation and cognitive impairment [0.03%]
系统性炎症导致认知功能障碍的表观遗传学机制研究
César Higgins Tejera,Peiyao Zhu,Erin B Ware et al.
César Higgins Tejera et al.
Background: Chronic inflammation and DNA methylation are potential mechanisms in dementia etiology. The linkage between inflammation and DNA methylation age acceleration in shaping dementia risk remains understudied. We e...
Targeting TET enzymes in ovarian cancer: epigenetic regulation, chemoresistance, and therapeutic opportunities [0.03%]
卵巢癌中TET酶的靶向作用：表观遗传调控、化疗耐药及治疗机会
Padival Shruptha,Jagadeesha Poyya,Thanvanthri Gururajan Vasudevan et al.
Padival Shruptha et al.
The intrinsic and acquired resistance of ovarian cancer to conventional platinum/taxane chemotherapy is approximately 80-85%, with a high recurrence rate, making it one of the most lethal gynecological cancers. Epigenetic dysregulation, a k...
A review of e-cigarettes and their effects on DNA methylation in human studies [0.03%]
电子烟对人类DNA甲基化影响的研究进展及未来方向
Naila Francis Paulo de Oliveira,Juliana Ramalho Guimarães,José Maria Chagas Viana Filho
Naila Francis Paulo de Oliveira
Background: The effects of conventional cigarette (c-cig) use on DNA methylation are well established, but the impact of electronic cigarettes (e-cigs) remains unclear. Objective: This scoping review aimed to map and synt...
Genome-wide methylation changes upon Caco-2 cells exposure to undigested and digested titanium dioxide nanoparticles [0.03%]
未消化和消化的二氧化钛纳米颗粒暴露下Caco-2细胞全基因组甲基化变化
Célia Ventura,Ana Valente,Luís Vieira et al.
Célia Ventura et al.
Introduction: Titanium dioxide nanoparticles (TiO2NPs) are relevant nanomaterials (NMs) for biomedicine and industry, which raise concerns about its effects on human health, particularly through ingestion. Several studies...
Beyond DNA binding: CTCF at the crossroads of chromatin architecture and epitranscriptomic regulation [0.03%]
超越DNA结合：CTCF在染色质结构和表转录组调控的交汇处
Oishi Mukherjee,Koustav Sarkar
Oishi Mukherjee
Transcriptional regulation is a crucial biological process that enables accurate gene expression, allowing cells to maintain their identity and respond to environmental stimuli. CCCTC-binding factor is a fundamental protein that actively in...
Integrating gut microbiome and host transcriptomics for the personalized management of IBD [0.03%]
整合肠道微生物组和宿主转录组学进行IBD的个性化管理
Darragh Barry,Cassandra Thachuk,Jackie Trink
Darragh Barry
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), affects an estimated 6.8 million individuals worldwide. Although biological or small molecule drug therapies can improve patient outcomes, loss of...
Blood and adipose tissue DNA methylation in adults born preterm with a very low birth weight - a sibling comparison study [0.03%]
极低出生体重的早产成人血液和脂肪组织DNA甲基化：一项同胞比较研究
Helena H Hauta-Alus,Justiina Ronkainen,Juho Kuula et al.
Helena H Hauta-Alus et al.
Background: Preterm birth and very low birth weight (VLBW;