DNA methylation of imprinted genes in Mexican-American newborn children with prenatal phthalate exposure [0.03%]
孕期接触邻苯二甲酸盐对墨西哥裔美国人新生儿印记基因DNA甲基化的影响
Gwen Tindula,Susan K Murphy,Carole Grenier et al.
Gwen Tindula et al.
Aim: Imprinted genes exhibit expression in a parent-of-origin-dependent manner and are critical for child development. Recent limited evidence suggests that prenatal exposure to phthalates, ubiquitous endocrine disruptors...
Exploration of drug-response mechanism by integrating genetics and epigenetics across cancers [0.03%]
通过跨癌症整合基因组学和表观遗传组学探索药物反应机制
Wenhua Lv,Mengying Zhang,Jiang Zhu et al.
Wenhua Lv et al.
Aim: To discover CpG island methylator phenotype (CIMP) as a predictor for cancer drug-response mechanism. Materials & methods: CIMP cl...
Time- and sex-dependent associations between prenatal alcohol exposure and placental global DNA methylation [0.03%]
孕期饮酒与胎盘DNA甲基化的时间及性别依赖性关联
Yuk Jing Loke,Evelyne Muggli,Linh Nguyen et al.
Yuk Jing Loke et al.
Aim: Epigenetic changes, in particular in the placenta, may mediate the effects of prenatal alcohol exposure (PAE) on children's health. We examined the relationship between PAE patterns, based on dose and timing, and pla...
Modus operandi of COMPASS/MLL epigenetic writers in the mammalian genome [0.03%]
COMPASS/MLL表观遗传修饰写入酶在哺乳动物基因组中的作用模式
Dashzeveg Bayarsaihan
Dashzeveg Bayarsaihan
Analysis of miRNA expression profiling identifies miR-214-3p as a novel biomarker in sinonasal inverted papilloma [0.03%]
微阵列分析鉴定出miR-214-3p为鼻腔乳头状瘤新型生物标志物
Yaoshu Teng,Yuandong Li,Zhihong Lin et al.
Yaoshu Teng et al.
Aim: To analyze the expression profile, diagnostic and clinicopathological significances of miRNAs in sinonasal inverted papilloma (SNIP). Materials & met...
The bitter side of epigenetics: variability and resistance to chemotherapy [0.03%]
表观遗传的另一面：差异性和对化疗的抗性
Nabil Hajji,Daniel J García-Domínguez,Lourdes Hontecillas-Prieto et al.
Nabil Hajji et al.
One of the major obstacles to the development of effective new cancer treatments and the main factor for the increasing number of clinical trial failures appears to be the paucity of accurate, reproducible and robust drug resistance testing...
Multilevel omic data clustering reveals variable contribution of methylator phenotype to integrative cancer subtypes [0.03%]
多层次的组学数据聚类揭示了甲基化表型对综合癌症亚型的不同贡献
Pawel Karpinski,Arpad V Patai,Wojciech Hap et al.
Pawel Karpinski et al.
Aim: We aimed to assess to what extent CpG island methylator phenotype (CIMP) contributes to cancer subtypes obtained by multilevel omic data analysis. Ma...
Combined SOM-portrayal of gene expression and DNA methylation landscapes disentangles modes of epigenetic regulation in glioblastoma [0.03%]
结合SOM描绘基因表达和DNA甲基化景观可解开胶质母细胞瘤表观遗传调控方式
Lydia Hopp,Henry Löffler-Wirth,Jörg Galle et al.
Lydia Hopp et al.
Aim: We present here a novel method that enables unraveling the interplay between gene expression and DNA methylation in complex diseases such as cancer. ...
Promoter methylation of PGC1A and PGC1B predicts cancer incidence in a veteran cohort [0.03%]
PGC1A和PGC1B启动子甲基化可预测退伍军人队列的癌症发生率
Jacob K Kresovich,Brian T Joyce,Tao Gao et al.
Jacob K Kresovich et al.
Aim: Previous studies suggest telomere shortening represses PGC1A and PGC1B expression leading to mitochondrial dysfunction. Methylation of CpG sites within these genes may interact with these factors to affect cancer ris...
The effect of inflammation-related lifestyle exposures and interactions with gene variants on long interspersed nuclear element-1 DNA methylation [0.03%]
炎症相关生活习惯暴露及其与基因变异相互作用对长散在核元件DNA甲基化的影响
Priyanka Gogna,Dylan E O&#x;Sullivan,Will D King
Priyanka Gogna
Aim: To examine the relationship between inflammation-related lifestyle factors and long interspersed nuclear element-1 (LINE-1) DNA methylation, and test for interaction by gene variants involved in one-carbon metabolism...