Gene body profiles of 5-hydroxymethylcytosine: potential origin, function and use as a cancer biomarker [0.03%]
5-羟甲基胞嘧啶基因体印记：潜在来源、功能及作为癌症生物标志物的用途
Gerd P Pfeifer,Piroska E Szabó
Gerd P Pfeifer
Integrated miRNA and mRNA expression profiling to identify mRNA targets of dysregulated miRNAs in pulmonary tuberculosis [0.03%]
整合miRNA和mRNA表达谱鉴定肺结核中异常表达的miRNA靶基因|mRNA
Xing Zhang,Min Zhu,Xiaolong Hu
Xing Zhang
Aim: The aim of this study was to identify mRNA targets of dysregulated miRNAs through the integrated analysis of miRNA and mRNA expression profiling in pulmonary tuberculosis (PTB) patients versus healthy individuals. ...
Dynamic changes of DNA methylation and lung disease in cystic fibrosis: lessons from a monogenic disease [0.03%]
囊性纤维化中DNA甲基化动态变化与肺部疾病：单基因疾病的启示
Milena Magalhães,Jörg Tost,Fanny Pineau et al.
Milena Magalhães et al.
Aim: To assess whether DNA methylation levels account for the noninherited phenotypic variations observed among cystic fibrosis (CF) patients. Patients & ...
Wei Chen,Ling Zhang,Changhua Shi et al.
Wei Chen et al.
Aim: This study aims to explore the similarity and difference of hippocampal miRNAomes between humans and mice. Materials & methods: A ...
Comparative Study
Epigenomics. 2018 Jun;10(6):813-828. DOI:10.2217/epi-2017-0161 2018
An epigenetic pacemaker is detected via a fast conditional expectation maximization algorithm [0.03%]
一种表观遗传老化时钟的检测方法及其快速条件期望最大化算法
Sagi Snir,Matteo Pellegrini
Sagi Snir
Aim: DNA methylation has proven to be a remarkably accurate biomarker for human age, allowing the prediction of chronological age to within a couple of years. Recently, we proposed that the Universal PaceMaker (UPM), a fl...
Limited efficacy of somatic cell lysis buffer to purify laboratory mouse sperm [0.03%]
用于小鼠精子纯化的体细胞裂解液的局限性
Brandon L Pearson,Leonie P Posselt,Kristin S Henzel et al.
Brandon L Pearson et al.
Aim: Epigenetic analyses of sperm require pure samples devoid of diploid cell contamination. We sought to determine the efficacy of somatic cell lysis buffer (SCLB) treatment to purify mouse epididymis sperm samples. ...
Epigenome mapping of human normal purified hepatocytes: personal epigenome variation and genome-epigenome correlation [0.03%]
人类正常肝细胞表观基因组测序及其变异和基因组表观基因组相关性分析
Eri Arai,Fumihito Miura,Yasushi Totoki et al.
Eri Arai et al.
Aim: The aim of this study was to reveal the epigenome landscape of human normal hepatocytes. Materials & methods: Cells purified from ...
Fabio Coppedè,Andrea Stoccoro,Alessandro Lazzarotti et al.
Fabio Coppedè et al.
Aim: To investigate GHSR and GHRL methylation in 73 pairs of colorectal cancer (CRC) tissues and healthy adjacent mucosa. Methods: Meth...
Comparative Study
Epigenomics. 2018 Dec;10(12):1525-1539. DOI:10.2217/epi-2018-0030 2018
Characterization of parent-of-origin methylation using the Illumina Infinium MethylationEPIC array platform [0.03%]
利用Illumina Infinium MethylationEPIC平台表征亲代特异性甲基化模式
Jose R Hernandez Mora,Chiharu Tayama,Marta Sánchez-Delgado et al.
Jose R Hernandez Mora et al.
Aim: This study aimed to establish a catalog of probes corresponding to imprinted differentially methylated regions (DMRs) on the Infinium HumanMethylationEPIC BeadChip. ...
Genetic variation at the long noncoding RNA H19 gene is associated with the risk of hypertrophic cardiomyopathy [0.03%]
长非编码RNA H19基因的遗传变异与肥厚型心肌病风险相关性研究
Juan Gómez,Rebeca Lorca,Julián R Reguero et al.
Juan Gómez et al.
Aim: The long noncoding RNA H19 and its host micro RNA miR-675 have been found deregulated in cardiac hypertrophy and heart failure tissues. Our aim was to investigate whether the H19 gene variants were associated with th...