Diagnostic and prognostic biomarkers of common urological cancers based on aberrant DNA methylation [0.03%]
基于DNA异常甲基化的常见泌尿系统癌症的诊断和预后生物标志物
Ding Peng,Guangzhe Ge,Zhengzheng Xu et al.
Ding Peng et al.
Aim: We intended to construct DNA methylation-based models for the diagnosis and prognosis of three common urological cancers including prostate adenocarcinoma, renal clear cell carcinoma and bladder urothelial carcinoma....
Screening key long non-coding RNAs in early-stage colon adenocarcinoma by RNA-sequencing [0.03%]
结肠腺癌早期关键长链非编码RNA的筛选及功能研究
Ji-Xi Liu,Wen Li,Jing-Tao Li et al.
Ji-Xi Liu et al.
Aim: We aim to identify the key long noncoding RNAs (lncRNAs) in early-stage colon adenocarcinoma (COAD). Patients & methods: Compared ...
Methylomic changes in response to micronutrient supplementation and MTHFR genotype [0.03%]
叶酸强化和基因型对表观遗传学的影响研究
Aaron J Stevens,Julia J Rucklidge,Kathryn A Darling et al.
Aaron J Stevens et al.
Exposure times and dosage required for dietary components to modify DNA methylation patterns are largely unknown. Aim: This exploratory research represent...
Randomized Controlled Trial
Epigenomics. 2018 Sep;10(9):1201-1214. DOI:10.2217/epi-2018-0029 2018
Circular RNA hsa_circ_0072995 promotes breast cancer cell migration and invasion through sponge for miR-30c-2-3p [0.03%]
Circular RNA hsa_circ_0072995通过海绵作用于miR-30c-2-3p促进乳腺癌细胞迁移和侵袭
He-Da Zhang,Lin-Hong Jiang,Jun-Chen Hou et al.
He-Da Zhang et al.
Aim: To study the role of hsa_circ_0072995 in regulating the invasion and migration of breast cancer cells. Materials & methods: Hsa_ci...
The upregulation of hypoxia-related miRNA 210 in primary tumor of lymphogenic metastatic prostate cancer [0.03%]
淋巴转移性前列腺癌原发肿瘤中缺氧相关microRNA 210的上调表达
Okyaz Eminaga,Jochen Fries,Susanne Neiß et al.
Okyaz Eminaga et al.
Aim: To show the association between the expression level of hsa-miR-210 (miR-210) and tumor progression in prostate cancer (PCa). Methods: ...
Integrated analysis of microfibrillar-associated proteins reveals MFAP4 as a novel biomarker in human cancers [0.03%]
微纤丝相关蛋白的综合分析揭示了MFAP4是人类癌症中的新型生物标志物
Jue Yang,Hui Song,Li Chen et al.
Jue Yang et al.
Aim: The potential functions and underlying mechanism of microfibrillar-associated proteins (MFAPs) are explored in human cancers. Materials & methods: ...
Mitochondrial DNA copy number and D-loop region methylation in carriers of amyotrophic lateral sclerosis gene mutations [0.03%]
渐冻症基因突变携带者线粒体DNA拷贝数和D-环区甲基化分析
Andrea Stoccoro,Lorena Mosca,Vittoria Carnicelli et al.
Andrea Stoccoro et al.
Aim: To investigate mitochondrial DNA (mtDNA) copy number and D-loop region methylation in carriers of SOD1, TARDBP, FUS and C9orf72 mutations. Methods: ...
Comparison of DNMT1 inhibitors by methylome profiling identifies unique signature of 5-aza-2'deoxycytidine [0.03%]
DNA去甲基化药物5-aza-2'-deoxycytidine特异靶向DNA甲基转移酶1的筛选与机制研究
Sarah-Jayne Mackin,Karla M O&#x;Neill,Colum P Walsh
Sarah-Jayne Mackin
Aim: 5-aza-2'deoxycytidine (Aza) is used to treat myelodysplastic syndrome and is in trials for other cancers. It acts chiefly as a hypomethylating agent inhibiting DNMT1. A lack of understanding of off-target effects in ...
Comparative Study
Epigenomics. 2018 Aug;10(8):1085-1101. DOI:10.2217/epi-2017-0171 2018
Very preterm birth is associated with PLAGL1 gene hypomethylation at birth and discharge [0.03%]
胎龄极小的早产儿出生时和出院时PLAGL1基因去甲基化程度较高
Livio Provenzi,Pietro De Carli,Monica Fumagalli et al.
Livio Provenzi et al.
Aim: Recent findings show that DNA methylation is susceptible to very preterm (VPT) birth and to the experience of the early stay in the neonatal intensive care unit. The aim of the study was to compare PLAGL1 methylation...
DNA methylation and gene expression profiling reveal MFAP5 as a regulatory driver of extracellular matrix remodeling in varicose vein disease [0.03%]
基于DNA甲基化和基因表达谱分析发现MFAP5通过调控细胞外基质重塑参与大隐静脉曲张发病机制
Mariya A Smetanina,Alexander E Kel,Ksenia S Sevost&#x;ianova et al.
Mariya A Smetanina et al.
Aim: To integrate transcriptomic and DNA-methylomic measurements on varicose versus normal veins using a systems biological analysis to shed light on the interplay between genetic and epigenetic factors. ...