Paternal preconception exercise and sperm epigenetic mechanisms: a systematic review on offspring health [0.03%]
父亲孕前运动和精子表观遗传机制：对后代健康影响的系统评价研究
Guilherme da Silva Rodrigues,Andressa Crystine da Silva Sobrinho,Ana Paulo Pinto et al.
Guilherme da Silva Rodrigues et al.
Introduction: Paternal biology before conception can influence offspring health beyond DNA sequence inheritance. Paternal exercise is a modifiable exposure that can remodel the male germline epigenome through DNA methylat...
Nicholas O&#x;Toole,Tie-Yuan Zhang,Eamon Fitzgerald et al.
Nicholas O&#x;Toole et al.
Background: Chronic social defeat stress (CSDS) is a validated animal model for depression that produces sustained behavioral and transcriptional changes in the brain, notably the nucleus accumbens (nAcc). ...
Inter-individual differentially methylated region-targeted EWAS reveals epigenetic signatures of early childhood adversity [0.03%]
个体间差异甲基化区域定位的表观遗传流行病学研究揭示了童年早期逆境的表观遗传特征
Taira Mayanagi,Junko Yagi,Hideki Ohmomo et al.
Taira Mayanagi et al.
Aims: Adverse childhood experiences (ACEs), especially in early life, can affect psychosocial development and increase lifelong risk for mental disorders. ACEs are also known to induce persistent epigenetic changes. This ...
Methylation changes of gallbladder DNA during the formation of gallstones [0.03%]
胆石形成过程中胆囊DNA甲基化的变化
Hongyu Xu,Jinlong Hu,Jinshan Liu et al.
Hongyu Xu et al.
Objective: To investigate the genome-wide methylation changes in gallbladder tissues during gallstone formation, as well as alterations in key signaling pathways and associated gene expression. ...
Circulating histones as potential biomarkers of MASLD-MASH-HCC progression [0.03%]
循环游离组蛋白作为MASLD-MASH-HCC进展生物标志物的潜力研究
Desislava K Tsoneva,Diana Buzova,Salvatore Daniele Bianco et al.
Desislava K Tsoneva et al.
Background: Reliable biomarkers are warranted to identify patients with metabolic dysfunction-associated steatotic liver disease (MASLD), including metabolic dysfunction-associated steatohepatitis (MASH), at risk for deve...
Periconceptional and prenatal nutrition shapes the fetal epigenomic landscape [0.03%]
围受精和宫内营养影响胎儿表观基因组景观
Mariana Parenti,Alison G Paquette
Mariana Parenti
Nutrition during pregnancy can influence fetal development and health across the lifespan. Prenatal nutrition is mechanistically linked to the epigenetic landscape because nutrients supply methyl groups and regulate microRNAs and proteins i...
High level of KMT5C is associated to better prognosis and its knockdown increases proliferation in head and neck cancer [0.03%]
KMT5C高表达与较好的预后相关且其敲低可增加头颈癌细胞的增殖能力
Lucas Oliveira Sousa,Gabriel da Silva,Thaís Moré Milan et al.
Lucas Oliveira Sousa et al.
Aim: The Histone methyl transferase KMT5C/SUV4-20H2 has been described as a promising marker in several types of cancer. We investigated the impact of KMT5C knockdown on cell proliferation capacity as well as its associat...
Mitochondrial DNA copy number reduction via in vitro TFAM knockout remodels the nuclear epigenome and transcriptome [0.03%]
通过体外TFAM敲除降低线粒体DNA拷贝数可重塑核表观基因组和转录组
Phyo W Win,Julia Nguyen,Elly H Shin et al.
Phyo W Win et al.
Aims: Mitochondrial DNA copy number (mtDNA-CN) is associated with several age-related chronic diseases and is a predictor of all-cause mortality. Here, we examine site-specific differential nuclear DNA (nDNA) methylation ...
Epigenome-wide mediation analysis identified Cytosine-phosphate-Guanine sites linking environmental factors with diabetes indicators [0.03%]
表观基因组中介分析确定了环境因素与糖尿病指标之间的CpG位点关系
Wan-Yu Lin
Wan-Yu Lin
Aims: Environmental factors can alter DNA methylation (DNAm) levels, influence gene expression, and then change fasting glucose (FG) or hemoglobin A1c (HbA1c). ...
Peripheral blood-based S100P hypomethylation as a biomarker for the early-stage non-small cell lung cancer [0.03%]
基于外周血的S100P低甲基化作为早期非小细胞肺癌生物标志物的研究
Junjie Li,Wenli Li,Rong Qiao et al.
Junjie Li et al.
Aim: Non-small cell lung cancer (NSCLC) has caused a heavy social and economic burden worldwide. DNA methylation, as an emerging blood biomarker, has great potential for early detection of NSCLC. ...