Mendelian disorders of the epigenetic machinery: a decade of insights into the molecular basis [0.03%]
表观遗传机器的 Mendelian 疾病：分子机制的认识十年回顾
Leandros Boukas,Hans T Bjornsson
Leandros Boukas
The Mendelian disorders of the Epigenetic Machinery (MDEMs), or Chromatinopathies, are now understood to be a collectively common cause of childhood neurodevelopmental delays and intellectual disability. In the past decade, the chromatin an...
Epigenetic modulators in triple-negative breast cancer: epigenetic modifications and future treatment perspectives [0.03%]
三阴性乳腺癌中的表观遗传调控剂：表观遗传修饰及未来治疗前景
Anita Choudhary,Pawan Kumar,Sohit Kashyap et al.
Anita Choudhary et al.
Triple Negative Breast Cancer (TNBC), an aggressive type of Breast Cancer (BC) characterized by the loss of expression of Estrogen Receptor (ER), Progesterone Receptor (PR), and Human Epidermal growth factor Receptor 2 (HER2) protein. TNBC ...
Global 5-methylcytosine and 5-hydroxymethylcytosine levels and their clinical associations in metabolic syndrome [0.03%]
代谢综合征中5-甲基胞嘧啶和5-羟甲基胞嘧啶水平及其临床相关性研究全球标准
Sacide Pehlivan,Yasemin Oyaci,Naci Şenkal et al.
Sacide Pehlivan et al.
Purpose: Metabolic syndrome (MetS) is a complex condition characterized by multiple metabolic abnormalities, in which epigenetic regulation has been increasingly implicated. This study aimed to evaluate global DNA methyla...
Regulation of TET function by PROSER1 in development and hematologic malignancies [0.03%]
PROSER1通过调节TET功能在发育和血液系统恶性肿瘤中的作用
Xiang Li,Kasper D Rasmussen
Xiang Li
Ten eleven translocation (TET) proteins are central regulators of DNA methylation homeostasis and play essential roles in development and disease, including hematopoietic malignancies. Among the three TET family members, mutations in TET2 a...
HOTAIR at the metabolic crossroads: lncRNA control of carbohydrate and lipid metabolism [0.03%]
代谢交汇点的HOTAIR：长链非编码RNA对碳水化合物和脂质代谢的调控
Julio Sánchez-Pérez,Samuel Trujano-Camacho,Verónica García-Castillo et al.
Julio Sánchez-Pérez et al.
Cancer cells reprogram their metabolic networks to sustain continuous proliferation, resist stress, and support invasive behavior. This metabolic rewiring includes enhanced aerobic glycolysis, increased glutaminolysis to fuel biosynthetic r...
Long-term molecular embedding of early life adversity: leukocyte DNA methylation and gene expression associations from childhood to young adulthood [0.03%]
早期生活逆境的长期分子嵌入：从儿童期到青年期的白细胞DNA甲基化和基因表达关联
Saher Daredia,Dennis Khodasevich,Anne K Bozack et al.
Saher Daredia et al.
Background: Early life adversity is associated with increased cardiometabolic risk across the life course, potentially via epigenetic mechanisms. However, few studies have prospectively examined how distinct domains of ea...
Overview of transcriptomics and epigenomics approaches in the diagnosis, prognosis, and therapeutics of primary brain cancers [0.03%]
转录组学和表观基因组学方法在原发性脑癌诊断、预后和治疗中的应用概述
Luna Guerra-Núñez,David Hughes-Herrera,Juan Manuel Molina-López et al.
Luna Guerra-Núñez et al.
Genome-wide approaches have unveiled multiple aspects of primary brain and spinal cord cancers regarding oncogenic processes, the tumor microenvironment, and mechanisms of resistance and sensitivity to therapy (among many others). In this r...
Ultra-sensitive urine DNA methylation test enables early and accurate detection of bladder cancer [0.03%]
超灵敏的尿液DNA甲基化检测可早期准确发现膀胱癌
Zhichao Tong,Tianxi Yu,Zhilong Li et al.
Zhichao Tong et al.
Background: Early and accurate detection of bladder cancer (BCa), particularly low-grade and early-stage disease, remains challenging because current diagnostic methods are either invasive or insufficiently sensitive. We ...
Promoter methylation-associated brain-enriched long noncoding RNAs in glioblastoma: a multi-cohort public epigenomic re-analysis [0.03%]
胶质母细胞瘤中与启动子甲基化相关的脑丰富型长链非编码RNA：多队列公共表观基因组的重新分析
Ye Tan,Fengyu Cheng,Pu Li et al.
Ye Tan et al.
Background: Glioblastoma (GBM) is epigenetically heterogeneous, and previous long noncoding RNA (lncRNA) methylation studies have often begun from tumor-wide screens. We asked whether brain-enriched lncRNAs show promoter ...
Ulrich Lehmann
Ulrich Lehmann
Tumor suppressor genes and DNA repair genes can be inactivated not only by genetic lesions, like mutations or deletions, but also by aberrant DNA methylation of promoter regions. These DNA methylation alterations may serve as biomarkers for...