Alu siRNA to increase Alu element methylation and prevent DNA damage [0.03%]
用于增加阿尔-u元件甲基化和防止DNA损伤的阿尔-u小干扰RNA
Maturada Patchsung,Sirapat Settayanon,Monnat Pongpanich et al.
Maturada Patchsung et al.
Global DNA hypomethylation promoting genomic instability leads to cancer and deterioration of human health with age. Aim: To invent a biotechnology that c...
Licong Shen,Yu Zhang,Wenjun Zhou et al.
Licong Shen et al.
Aim: Circular RNAs (circRNAs) with miRNA response elements (MREs) could function as competing endogenous RNA (ceRNA) in regulating gene expression. This study was carried out to identify the expression profile and role of...
Phuc-Loi Luu,Daniela Gerovska,Hans R Schöler et al.
Phuc-Loi Luu et al.
Aim: Disclosing the mechanisms that regulate reprogramming memory. Materials & methods: We established computational procedure to find ...
NGS-based methylation profiling differentiates TCF3-HLF and TCF3-PBX1 positive B-cell acute lymphoblastic leukemia [0.03%]
基于NGS的甲基化谱分析可区分TCF3-HLF和TCF3-PBX1阳性B淋巴细胞急性淋巴细胞性白血病
Priyadarshini Kachroo,Silke Szymczak,Femke-Anouska Heinsen et al.
Priyadarshini Kachroo et al.
Aim: To determine whether methylation differences between mostly fatal TCF3-HLF and curable TCF3-PBX1 pediatric acute lymphoblastic leukemia subtypes can be associated with differential gene expression and remission. ...
Circular RNA expression in extracellular vesicles isolated from serum of patients with endometrial cancer [0.03%]
子宫内膜癌患者血清分离的外泌体中的环状RNA表达
Hanzi Xu,Zhen Gong,Yang Shen et al.
Hanzi Xu et al.
Aim: We aimed to explore the roles of circular RNAs (circRNAs) in extracellular vesicles (EVs) isolated from serum of patients with endometrial cancer. Ma...
Brandon L Pearson,Dan Ehninger
Brandon L Pearson
Development and disease in a dish: the epigenetics of neurodevelopmental disorders [0.03%]
从发育到疾病：神经发育障碍的表观遗传学
Emily Ma Lewis,Kristen L Kroll
Emily Ma Lewis
Human neurodevelopmental disorders (NDDs) involve mutations in hundreds of individual genes, with over-representation in genes encoding proteins that alter chromatin structure to modulate gene expression. Here, we highlight efforts to model...
Transcriptional regulation on the gene expression signature in combined allergic rhinitis and asthma syndrome [0.03%]
共患过敏性鼻炎和哮喘综合征中的基因表达特征的转录调控
Zhengdao Mao,Yujia Shi,Qi Cao et al.
Zhengdao Mao et al.
Aim: This study was intended to evaluate transcriptional regulation of gene expression signatures in combined allergic rhinitis and asthma syndrome (CARAS). ...
DNA methylation changes and evolution of RNA-based duplication in Sus scrofa: based on a two-step strategy [0.03%]
基于两步策略的猪基因组DNA甲基化变化及RNA作用机制研究
Chengchi Fang,Cheng Zou,Yuhua Fu et al.
Chengchi Fang et al.
Aim: This study aims to couple DNA methylation changes and evolution of retrogenes. Materials & methods: A new two-step strategy was de...
Intracellular African swine fever virus DNA remains unmethylated in infected Vero cells [0.03%]
非洲猪瘟病毒DNA在感染的vero细胞内保持非甲基化状态
Stefanie Weber,Astghik Hakobyan,Hovakim Zakaryan et al.
Stefanie Weber et al.
Aim: Sequence-specific CpG methylation of eukaryotic promoters is an important epigenetic signal for long-term gene silencing. We have now studied the methylation status of African swine fever virus (ASFV) DNA at various ...