Integrating gut microbiome and host transcriptomics for the personalized management of IBD [0.03%]
整合肠道微生物组和宿主转录组学进行IBD的个性化管理
Darragh Barry,Cassandra Thachuk,Jackie Trink
Darragh Barry
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), affects an estimated 6.8 million individuals worldwide. Although biological or small molecule drug therapies can improve patient outcomes, loss of...
Blood and adipose tissue DNA methylation in adults born preterm with a very low birth weight - a sibling comparison study [0.03%]
极低出生体重的早产成人血液和脂肪组织DNA甲基化：一项同胞比较研究
Helena H Hauta-Alus,Justiina Ronkainen,Juho Kuula et al.
Helena H Hauta-Alus et al.
Background: Preterm birth and very low birth weight (VLBW;
5mC and 5hmC methylation sequencing: the power of 6-base sequencing in a multiomic era [0.03%]
5mC和5hmC甲基化测序：六碱基测序在组学时代的优势
Robert Crawford,Tom Charlesworth,Stephen Riffle et al.
Robert Crawford et al.
The integration of genetic and epigenetic information is essential for a comprehensive understanding of genome function and regulation. Traditional sequencing methods often fall short in capturing both genetic variants and epigenetic modifi...
ALKBH5-mediated m6A demethylation of TXNDC5 drives malignant progression in gastric cancer [0.03%]
胃癌中ALKBH5介导的TXNDC5去甲基化驱动恶性进展
Wenkun Peng,Xiaoquan Wei,Feifei Zhou et al.
Wenkun Peng et al.
Background: Gastric cancer (GC) remains a leading cause of cancer-related mortality worldwide. N6-methyladenosine (m6A) modification plays a critical role in post-transcriptional gene regulation. This study aimed to eluci...
Epigenetic regulation of MMP-11 and -16 expression in human prostate cancer: the role of KDM6A [0.03%]
KDM6A在人类前列腺癌中通过表观遗传学调控基质金属蛋白酶MMP-11和MMP-16表达中的作用
Gökçe Yıldırım-Buharalıoğlu,Recep İlhan,Yaren Çakmak et al.
Gökçe Yıldırım-Buharalıoğlu et al.
Aims: Matrix metalloproteinases (MMPs) promote prostate cancer (PCa) progression by degrading the extracellular matrix and enhancing metastasis. PCa is considered an "epigenetic catastrophe" due to disrupted histone modif...
The epigenetic mechanisms of ketamine in the treatment of depression: a systematic review [0.03%]
氯胺酮治疗抑郁症的表观遗传机制：系统评价研究
Ivana Leccisotti,Maria Claudia Moretti,Mario Altamura et al.
Ivana Leccisotti et al.
Aim: Ketamine antidepressant effects go beyond immediate receptor action, involving lasting transcriptional and epigenomic changes that support its rapid, long-lasting benefits. The present systematic review synthesized e...
Epigenetic dysregulation of high-grade gliomas: from heterogeneity to brain network modulation [0.03%]
高度恶性的胶质瘤的表观遗传调控：从异质性到脑网络调节
Kiyohito Murai,Nozomi Kobayashi,Wataru Tarumi et al.
Kiyohito Murai et al.
High-grade gliomas (HGGs), including glioblastoma and diffuse midline glioma, highlight one of the most aggressive brain tumors in adults and children with dismal prognosis despite intensive treatment regimens. Recently, epigenetic dysregul...
Differential microRNA profiling of blood L1CAM and bulk extracellular vesicles in bipolar disorder [0.03%]
双相障碍患者血液L1CAM和总体外泌体的微小RNA谱分析
Gabriel R Fries,Salahudeen Mirza,Jun Wang et al.
Gabriel R Fries et al.
Objective: This preliminary study aimed to identify microRNA (miRNA) signatures associated with bipolar disorder (BD) by profiling blood-derived extracellular vesicles (EVs) of both putative neuronal origin and from all s...
Advancing epigenetic signatures as functional biomarkers in rare diseases [0.03%]
推进表观遗传特征在罕见病中的功能生物标志物作用
Andrea Ciolfi,Marco Ferilli,Camilla Cappelletti et al.
Andrea Ciolfi et al.
Alterations of the DNA methylation (DNAm) status of the genome underlie an increasing number of rare diseases. Recently, DNAm has also emerged as a highly informative biomarker for diagnosing rare disorders, which can be associated with dis...
Hiroaki Ohishi,Wan Kin Au Yeung
Hiroaki Ohishi
Rapid methodological breakthroughs over the past ten years have transformed epigenomics from bulk, population-averaged assays into single-cell, multi-omic, and intracellular spatial investigations. This review surveys the interconnected tec...