Takahiro Ebata,Qichun Wang,Hideyuki Takeshima et al.
Takahiro Ebata et al.
Aim: To establish an analytical method for human DNA contamination with mouse DNA using a DNA methylation microarray. Materials and methods: ...
Reduction in ELOVL2 methylation following curative surgery in lung cancer patients: an observational study [0.03%]
Peixian Li,Zhuxing Chen,Xiaowen Zhang et al.
Peixian Li et al.
Background: While tumors are known to accelerate epigenetic aging, it remains unclear whether curative surgery can reverse this effect in early-stage lung cancer patients. ELOVL2 methylation is a well-established biomarke...
Combining epigenetic therapy and immunotherapeutic avenues for chronic HBV infection [0.03%]
表观遗传学治疗和免疫治疗联合对抗慢性HBV感染
Yin-Han Chou,Markus Cornberg
Yin-Han Chou
S-adenosylmethionine as an epigenetic treatment of depression in adults with childhood trauma [0.03%]
S腺苷蛋氨酸作为儿童创伤成人患者的表观遗传学治疗抑郁症的方法
Anne Alkema,Winni Schalkwijk,Evelien Bohte et al.
Anne Alkema et al.
Background: Childhood trauma is associated with increased risk of depression and epigenetic alterations in stress-related pathways. Preclinical studies suggest that methyl donors may facilitate DNA methylation changes. Th...
KMT2B induces the H3K4 trimethylation of RBBP6 promoter to enhance the 131I sensitivity in thyroid carcinoma by restraining STAT1/DPP4 axis [0.03%]
KMT2B通过限制STAT1/DPP4轴诱导RBBP6启动子的H3K4三甲基化以增强甲状腺癌对¹³¹I的敏感性
Meiqun Wang,Zhi Wang,Haifeng Yang et al.
Meiqun Wang et al.
Background: Radioactive iodine (RAI) resistance severely limits treatment efficacy in thyroid carcinoma (THCA), yet its molecular underpinnings remain incompletely elucidated. In the present study, we sought to reveal the...
Computational-based integrative methylome-transcriptome analysis reveals widespread enhancer hypomethylation in esophageal carcinoma [0.03%]
基于计算的整合甲基化组-转录组分析揭示食管癌中增强子低甲基化的广泛存在
Akbar Ali,Tengku Ahmad Damitri Al Astani Tengku Din,Muhammad Irfan Abdul Jalal et al.
Akbar Ali et al.
Background: Esophageal carcinoma (ESCA), comprising esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC), has a poor prognosis due to late diagnosis and incomplete molecular characterization. We s...
Longitudinal study of genome-wide DNA methylation in individuals with and without post-acute symptoms following SARS-CoV-2 infection [0.03%]
针对SARS-CoV-2感染后急性期症状轻重不同的个体进行的全基因组DNA甲基化纵向研究
Jon Bohlin,Yunsung Lee,Ida Henriette Caspersen et al.
Jon Bohlin et al.
Background: Symptoms following SARS-CoV-2 infection, referred to as Long-COVID, have been reported since the pandemic. We investigated whether COVID-19 or Long-COVID is associated with persistent genome-wide DNA methylati...
Estrogen-induced epigenetic silencing of myotrophin reduces proliferation and is associated with chemosensitivity in hepatocellular carcinoma cells [0.03%]
雌激素通过表观遗传沉默肌营养不良蛋白减少肝癌细胞增殖并促其对化疗的敏感性
Jibran Sualeh Muhammad,Bilal Rah,Nouf Khan et al.
Jibran Sualeh Muhammad et al.
Background: Hepatocellular carcinoma (HCC) carries poor survival and limited response to conventional chemotherapy. Epidemiological evidence suggests a lower incidence of HCC in females, implicating estrogen (E2) in tumor...
Charlotte A M Cecil,Janine F Felix,Alexander Neumann
Charlotte A M Cecil
DNA methylation (DNAm) is highly dynamic across the life course; yet, most studies examine it at a single time point and control for age in their analyses. Here we discuss how these practices risk obscuring epigenetic timing effects: age-de...
miRNA profiling of a mutation-negative PKD cohort reveals PKD1/PKD2 ADPKD shared signatures and differences [0.03%]
基于microRNA谱对一个无突变常染色体显性多囊肾病队列的研究揭示了PKD1/PKD2基因的共有特征及差异
Bruna De Felice,Ersilia Nigro,Maria Amicone et al.
Bruna De Felice et al.
Background: Autosomal dominant polycystic kidney disease (ADPKD) is mainly caused by mutations in PKD1 or PKD2 genes, but a subgroup of patients has no detectable mutation and remains understudied. We profiled microRNAs (...