A manifesto for Alzheimer's disease drug discovery in the era of disease-modifying therapies [0.03%]
改良疗法时代阿尔茨海默病药物研发宣言
Heike Hering,Thierry Bussiere,Chia-Chen Liu et al.
Heike Hering et al.
After decades of disappointment, three disease-modifying therapies for Alzheimer's disease (AD) have been approved since 2021. Burgeoning clinical data on these amyloid β-protein (Aβ) targeting drugs validate the amyloid cascade hypothesi...
LRRK2 kinase activity regulates Parkinson's disease-relevant lipids at the lysosome [0.03%]
LRRK2激酶活性调节溶酶体上与帕金森病相关的脂质
Michael T Maloney,Xiang Wang,Rajarshi Ghosh et al.
Michael T Maloney et al.
Background: Pathogenic variants in LRRK2 lead to increased kinase activity, and LRRK2 kinase inhibition is being explored in clinical studies as a therapeutic approach for Parkinson's Disease (PD). LRRK2 inhibitors reduce...
Retraction Note: Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5- implications for dementia with lewy bodies [0.03%]
撤回 notice: 突触核蛋白片段积聚的海马神经元细胞通过mGluR5更容易受到Aβ寡聚毒性的影响—路易体痴呆的意义
Cassia R Overk,Anna Cartier,Gideon Shaked et al.
Cassia R Overk et al.
Glycerophospholipids in ALS: insights into disease mechanisms and clinical implication [0.03%]
ALS中甘油磷脂的见解：对疾病机制和临床意义的影响
Thibaut Burg,Ludo Van Den Bosch
Thibaut Burg
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease affecting the adult motor system, with no effective treatments available. Despite extensive research efforts, the exact pathological cascade leading to progressi...
The role of endolysosomal progranulin and TMEM106B in neurodegenerative diseases [0.03%]
内溶酶体蛋白原生长调节素和TMEM106B在神经退行性疾病中的作用
Hideyuki Takahashi,Stephen M Strittmatter
Hideyuki Takahashi
Although different neurodegenerative diseases are defined by distinct pathological proteins, they share many common features including protein aggregation. Despite this commonality, most current therapeutic approaches in the field, such as ...
Endothelium-specific endoglin triggers astrocyte reactivity via extracellular vesicles in a mouse model of Alzheimer's disease [0.03%]
内皮特异性的endothelin在阿尔茨海默病小鼠模型中通过细胞外囊泡触发星形胶质细胞反应性
Pingao Zhang,Chenghuan Song,Jiyun Shi et al.
Pingao Zhang et al.
Background: Alzheimer's disease (AD) is a multifaceted neurodegenerative disorder with a complex etiology that extends beyond the well-documented amyloid-β and tau pathologies. Growing evidence implicates cerebrovascular...
Proteomic landscape of Alzheimer's disease: emerging technologies, advances and insights (2021 - 2025) [0.03%]
阿尔茨海默病的蛋白质组学特征：新兴技术、进展和见解（2021-2025）
Jay M Yarbro,Him K Shrestha,Zhen Wang et al.
Jay M Yarbro et al.
The advancements of proteomics technologies are shaping Alzheimer's disease (AD) research, revealing new molecular insights and improving biomarker discovery. Here, we summarize major AD proteomics studies since our 2021 review, focusing on...
Biomarkers and therapeutic strategies targeting microglia in neurodegenerative diseases: current status and future directions [0.03%]
神经退行性疾病中靶向小胶质细胞的生物标志物和治疗策略：现状与未来方向
Min-Young Noh,Hyuk Sung Kwon,Min-Soo Kwon et al.
Min-Young Noh et al.
Recent advances in our understanding of non-cell-autonomous mechanisms in neurodegenerative diseases (NDDs) have highlighted microglial dysfunction as a core driver of disease progression. Conditions such as Alzheimer's disease (AD), amyotr...
Glial phagocytosis for synapse and toxic proteins in neurodegenerative diseases [0.03%]
神经退行性疾病中的胶质细胞吞噬作用及其对突触和毒性蛋白的作用
Yeseong Choi,Won-Suk Chung
Yeseong Choi
Glia, as resident immune and supportive cells of the central nervous system, play a critical role in maintaining brain homeostasis. One of their key homeostatic functions is phagocytic capacity in pruning synapses and removing cellular debr...
Methylome analysis of FTLD patients with TDP-43 pathology identifies epigenetic signatures specific to pathological subtypes [0.03%]
TDP-43病理FTLD患者甲基化组分析鉴定出特异于病理亚型的表观遗传标志
Cristina T Vicente,Tejasvi Niranjan,Elise Coopman et al.
Cristina T Vicente et al.
Background: In the last decade, the importance of DNA methylation in the functioning of the central nervous system has been highlighted through associations between methylation changes and differential expression of key g...