AQP4-dependent enhancement of glymphatic function attenuates tau pathology and neurodegeneration in PS19 mice [0.03%]
AQP4依赖的糖酵解功能增强可减轻PS19小鼠中的tau病理和神经退行性病变
Kaoru Yamada,Kazuhisa Ishida,Asami Sakamoto et al.
Kaoru Yamada et al.
Background: The glymphatic system facilitates cerebrospinal fluid-interstitial fluid exchange and contributes to the clearance of pathogenic proteins from the brain. Glymphatic dysfunction has been associated with Alzheim...
The complex lipidome as a driver of tissue-specific pathology in adrenoleukodystrophy [0.03%]
脑肾上腺素 leukodystrophy 中组织特异性病理的脂质组驱动因素
Stephan Kemp,Marc Engelen,Yorrick R J Jaspers
Stephan Kemp
X-linked adrenoleukodystrophy (ALD) is an inherited peroxisomal disorder caused by pathogenic variants in the ABCD1 gene, encoding a peroxisomal membrane transporter required for the import of very-long-chain fatty acids (VLCFA) into peroxi...
Diabetic retinopathy: shaped by the "hidden hand" of post-translational modifications [0.03%]
糖尿病视网膜病变：“无形之手”——翻译后修饰的影响
Ruihan Xiao,Meixia Zhang
Ruihan Xiao
Diabetic retinopathy (DR), a leading cause of vision loss in working-age adults, is increasingly recognized as a combination of neurodegenerative and microvascular disease of the retina. Its pathological mechanism is complex, involving the ...
Transplantation of human iPSC-derived microglia ameliorates neuropathology and circuit dysfunction in progranulin-deficient mice [0.03%]
人诱导多能干细胞来源的小胶质细胞移植改善了前列腺素受体缺陷型小鼠的神经病理和回路功能障碍
Hayk Davtyan,Sarah Naguib,Yuliya Voskobiynyk et al.
Hayk Davtyan et al.
Frontotemporal dementia (FTD) is a major cause of early-onset neurodegeneration characterized by progressive behavioral, emotional, and cognitive decline. Progranulin haploinsufficiency, a leading genetic cause of familial FTD, disrupts lys...
Passive amyloid-β immunotherapy in Alzheimer's disease: a multicellular clearance system beyond plaque removal [0.03%]
阿尔茨海默病的被动型β淀粉样蛋白免疫治疗：超出斑块清除的多细胞清除系统
Xiaoni Zhan,Chenchen Liu,Changjiang Yu et al.
Xiaoni Zhan et al.
Passive immunotherapy targeting amyloid-β (Aβ) has emerged as a major therapeutic strategy for Alzheimer's disease (AD), yet its clinical benefits remain modest and are frequently accompanied by vascular adverse events such as amyloid-rel...
Atypical chemokine receptor 3 regulates synaptic removal in disease astrocytes [0.03%]
非典型趋化因子受体3调节疾病星形胶质细胞的突触清除作用
V Giusti,J Park,E Giusto et al.
V Giusti et al.
Astrocytes participate in the clearance of obsolete or unwanted neuronal synapses. However, the molecular machinery involved in synapse recognition remains unclear, particularly in pathological conditions. Here, we investigated the phagocyt...
Breaking the glial loop: astrocytic PAD2 and citrullinated vimentin drive microglial dysfunction in Alzheimer's disease [0.03%]
破解胶质细胞环路：星形胶质细胞PAD2和变性波形蛋白驱动阿尔茨海默病小胶质细胞功能障碍
Jeff Y L Lam,Guojun Bu
Jeff Y L Lam
Zhang et al. reveal that astrocytic PAD2-mediated citrullination of vimentin drives a TLR4-dependent pro-inflammatory loop in microglia, linking glial crosstalk to impaired amyloid clearance and identifying a potential therapeutic and bioma...
Molly M Watkins,Gisela Xhafkollari,Na Zhao et al.
Molly M Watkins et al.
Lewy body dementia (LBD) is a clinically and pathologically complex neurodegenerative disease. Its etiology remains poorly understood and, as such, it is likely underdiagnosed in clinical practice. Clinically, LBD is defined by fluctuations...
ApoE lipoproteins in the central nervous system under homeostasis and role in Alzheimer's disease and related disorders [0.03%]
稳态下中枢神经系统中的ApoE脂蛋白及其在阿尔茨海默病及相关疾病中的作用
Michael R Strickland,David M Holtzman
Michael R Strickland
Apolipoprotein E (ApoE) is highly expressed in the central nervous system (CNS) where it plays a critical role in lipid homeostasis and in the etiology of Alzheimer's disease (AD) and related diseases. ApoE associates with lipids to form di...
The human LRRK2-R1441G mutation drives age-dependent oxidative stress and mitochondrial dysfunction in dopaminergic neurons [0.03%]
人类LRRK2-R1441G突变驱动多巴胺能神经元中的年龄依赖性氧化应激和线粒体功能障碍
Yuanxin Chen,Lianteng Zhi,Shiquan Cui et al.
Yuanxin Chen et al.
Background: Mitochondrial dysfunction and oxidative stress are central to the pathogenesis of Parkinson's disease (PD), particularly affecting substantia nigra pars compacta (SNc) dopamine (DA) neurons. Here, we investiga...