RAN translation as a dominant pathogenic axis in C9ORF72-associated ALS and FTD models [0.03%]
C9ORF72相关的ALS和FTD模型中RAN翻译为主要的致病轴
Pegah Masrori,Defne Audrey Amado
Pegah Masrori
Tau extent outperforms tau load as a predictor of neurodegeneration in Alzheimer's disease [0.03%]
tau蛋白累积量预测阿尔茨海默病神经退行性病变优于tau蛋白负荷
Arthur C Macedo,Lydia Trudel,Seyyed Ali Hosseini et al.
Arthur C Macedo et al.
Background: In Alzheimer's disease (AD), tau pathology is more strongly linked to neurodegeneration than amyloid-β and better predicts brain atrophy. The spatial extent of tauopathy (SEOT) has shown promise as an earlier...
Insulin resistance alters cortical inhibitory neurons and microglia to exacerbate Alzheimer's knock-in mouse phenotypes [0.03%]
胰岛素抵抗可改变皮质抑制性神经元和小胶质细胞以加剧阿尔茨海默病敲入小鼠表型
LaShae Nicholson,Si Jie Tang,Tejaswini Karra et al.
LaShae Nicholson et al.
Background: Metabolic dysfunction contributes to the risk and progression of Alzheimer's disease (AD), yet the cellular mechanisms linking impaired insulin signaling and systemic metabolic stress to brain dysfunction rema...
Minjuan Bian,Emma L Huie,Xin Xia et al.
Minjuan Bian et al.
Background: In the adult mammalian central nervous system (CNS), failure of axon regeneration limits recovery after traumatic injury or in neurodegenerative disease. Local protein translation has been implicated in the re...
Temporal single-cell atlas of full-length Huntington's disease mouse model defines stage-specific signatures of corticostriatal dysfunction [0.03%]
时间单细胞图谱定义了全长度亨廷顿舞蹈病小鼠模型纹状体病变的阶段特异性分子特征
Ashley B Robbins,Paul T Ranum,Icnelia Huerta-Ocampo et al.
Ashley B Robbins et al.
Background: Huntington's disease (HD) involves progressive corticostriatal dysfunction, yet the temporal dynamics and cell type-specific vulnerability patterns remain incompletely understood. While recent single-cell stud...
Correction: Decoding distinctive features of plasma extracellular vesicles in amyotrophic lateral sclerosis [0.03%]
订正：解码外周血外泌体区别特征在肌萎缩侧索硬化中的作用
Laura Pasetto,Stefano Callegaro,Alessandro Corbelli et al.
Laura Pasetto et al.
Published Erratum
Molecular neurodegeneration. 2026 May 27;21(1):29. DOI:10.1186/s13024-026-00955-z 2026
Cholesterol metabolism in neurodegenerative diseases: mechanisms and therapeutic advances [0.03%]
神经退行性疾病中的胆固醇代谢：机制和治疗进展
Dezhen Tu,Yuxiao Zheng,Pingping Ding et al.
Dezhen Tu et al.
Cholesterol metabolites are abundant in the central nervous system (CNS) that regulate cell membrane fluidity, signal transduction, and inter- and intracellular vesicular transport, as well as cell proliferation/cell death or migration. Bra...
Neurodegeneration as an evolutionary trade-off: a biological constraint-aware therapeutic perspective [0.03%]
神经退行性病变作为进化权衡：一种具有生物学限制意识的治疗观点
Seung Hyun Kim,Min-Young Noh,Matthew C Kiernan
Seung Hyun Kim
In vivo profiling of astrocyte secretome reveals brain-region specific regulatory networks in a mouse model of amyloid pathology [0.03%]
活体星形胶质细胞分泌组谱分析在淀粉样蛋白病理性小鼠模型中揭示脑区特异性调控网络
Qiu Jiang,Jian-Ni Hu,Hao-Min Dong et al.
Qiu Jiang et al.
Coordinated cell-to-cell communications is crucial for the proper functioning and maintenance of brain activities, and its disruption contributes to neurological disorders, including Alzheimer's disease (AD). Altered astrocyte-neuron commun...
Dual orexin receptor antagonism with lemborexant enhances microglial clearance of β-amyloid in mice [0.03%]
双食欲素受体拮抗剂lemborexant通过增强小胶质细胞清除β淀粉样蛋白在小鼠模型中的作用机制研究
Ashish Sharma,Emiko Segawa,Xiaoying Chen et al.
Ashish Sharma et al.
Background: Sleep disturbances elevate brain amyloid-beta (Aβ) levels and represent a modifiable risk factor for Alzheimer's disease (AD). The orexin/hypocretin system regulates sleep-wake behavior and has emerged as a t...