A novel alpha-synuclein G14R missense variant is associated with atypical neuropathological features [0.03%]
新型α-突触核蛋白G14R错义变异与非典型神经病理特征相关性研究
Christof Brücke,Mohammed Al-Azzani,Nagendran Ramalingam et al.
Christof Brücke et al.
Background: Parkinson's disease (PD) affects millions of people worldwide, but only 5-10% of patients suffer from a monogenic forms of the disease with Mendelian inheritance. SNCA, the gene encoding for the protein alpha-...
Autophagic impairment in sleep-wake circuitry is linked to sleep loss at the early stages of Alzheimer's disease [0.03%]
自闭症睡眠-清醒回路中自噬作用的损害与阿尔茨海默病早期阶段的失眠有关
Christopher Daniel Morrone,Arielle A Tsang,W Haung Yu
Christopher Daniel Morrone
Background: Proteostasis, in particular the impairment of autophagic activity, is linked to sleep dysregulation and is an early sign of dementias including Alzheimer's disease (AD). This coupling of events may be a critic...
APOE genotype influences on the brain metabolome of aging mice - role for mitochondrial energetics in mechanisms of resilience in APOE2 genotype [0.03%]
载脂蛋白E基因型对衰老小鼠脑代谢组的影响-APOE2基因型抵抗机制中的线粒体能量代谢作用
Kamil Borkowski,Nuanyi Liang,Na Zhao et al.
Kamil Borkowski et al.
Alzheimer’s disease (AD) risk and progression are significantly influenced by APOE genotype with APOE4 increasing and APOE2 decreasing susceptibility compared to APOE3. While the effect of those genotypes was extensively studied on blood m...
Recombinant cathepsins B and L promote α-synuclein clearance and restore lysosomal function in human and murine models with α-synuclein pathology [0.03%]
人和小鼠α-突触核蛋白病理模型中重组猫溶酶体半胱氨酸蛋白酶B和L促进α-突触核蛋白清除并恢复溶酶体功能
Denise Balta,Anish Varghese,Susy Prieto Huarcaya et al.
Denise Balta et al.
The autophagy-lysosomal pathway is crucial for maintaining homeostasis and survival of neurons, hence defects in this system have been associated with neurodegeneration, including Parkinson's disease (PD). The cysteine proteases cathepsin B...
β-Amyloid induces microglial expression of GPC4 and APOE leading to increased neuronal tau pathology and toxicity [0.03%]
β-淀粉样蛋白诱导的小胶质细胞GPC4和APOE表达增加促进神经元tau病理改变和毒性
Brandon B Holmes,Thaddeus K Weigel,Jesseca M Chung et al.
Brandon B Holmes et al.
To define how Aβ pathology alters microglia function in Alzheimer’s disease, we profiled the microglia surfaceome following treatment with Aβ fibrils. Our findings reveal that Aβ-associated human microglia upregulate Glypican 4 (GPC4), ...
MS4A6A/Ms4a6d deficiency disrupts neuroprotective microglia functions and promotes inflammation in Alzheimer's disease model [0.03%]
MS4A6A/Ms4a6d缺陷通过破坏阿尔茨海默病模型中的神经保护性小胶质细胞功能来促进炎症反应
Hai-Shan Jiao,Yi-Jun Ge,Liang-Yu Huang et al.
Hai-Shan Jiao et al.
Background: Alzheimer's disease (AD) is the most common type of dementia. Genetic polymorphisms are associated with altered risks of AD onset, pointing to biological processes and potential targets for interventions. Cons...
Large-scale CSF proteome profiling identifies biomarkers for accurate diagnosis of frontotemporal dementia [0.03%]
基于脑脊液的大规模蛋白质组学鉴定可用于 frontal temporal lobe dementia 准确诊断的生物标志物
Yanaika S Hok-A-Hin,Lisa Vermunt,Carel F W Peeters et al.
Yanaika S Hok-A-Hin et al.
Correction: Clinical progression and genetic pathways in body-first and brain-first Parkinson's disease [0.03%]
纠正：身体优先和大脑优先帕金森病的临床进展和遗传途径
Massimiliano Passaretti,Daniel Veréb,Mite Mijalkov et al.
Massimiliano Passaretti et al.
Published Erratum
Molecular neurodegeneration. 2025 Aug 20;20(1):91. DOI:10.1186/s13024-025-00885-2 2025
Early intervention anti-Aβ immunotherapy attenuates microglial activation without inducing exhaustion at residual plaques [0.03%]
早期的抗Aβ免疫疗法可以减轻小胶质细胞活化而不诱发残余淀粉样斑块的小胶质细胞耗竭
Lis de Weerd,Selina Hummel,Stephan A Müller et al.
Lis de Weerd et al.
Anti-amyloid β-peptide (Aβ) immunotherapy was developed to reduce amyloid plaque pathology and slow cognitive decline during progression of Alzheimer's disease. Efficient amyloid clearance has been proven in clinical trials testing anti-A...
Lewy body dementia: exploring biomarkers and pathogenic interactions of amyloid β, tau, and α-synuclein [0.03%]
路易体痴呆：探索淀粉样蛋白β、tau和α-突触核蛋白的生物标志物及致病互作关系
Jingfeng Liang,Rongzhen Li,Garry Wong et al.
Jingfeng Liang et al.