Synaptic dysfunction and glial activation markers throughout aging and early neurodegeneration: a longitudinal CSF biomarker-based study [0.03%]
基于纵向脑脊液生物标志物的研究：老化及早期神经退行性病变中的突触功能障碍和胶质活化标记物变化
Mariana I Muñoz-García,Yuetiva Deming,Ferran Lugo-Hernández et al.
Mariana I Muñoz-García et al.
Background: Synaptic homeostasis, maintained by microglia and astroglia, is disrupted throughout aging and early on in neurodegenerative diseases. Our aim was to study the relationship between TREM2-dependent microglial r...
Modeling neurodegeneration in the retina and strategies for developing pan-neurodegenerative therapies [0.03%]
视网膜神经退行性疾病的建模及泛用神经退行性疾病治疗策略的开发
Emily L Ward,Larry Benowitz,Thomas M Brunner et al.
Emily L Ward et al.
Background: Glaucoma Research Foundation's third Catalyst for a Cure team (CFC3) was established in 2019 to uncover new therapies for glaucoma, a leading cause of blindness. In the 2021 meeting "Solving Neurodegeneration,...
Cerebrospinal fluid markers link to synaptic plasticity responses and Alzheimer's disease genetic pathways [0.03%]
脑脊液生物标志物与阿尔茨海默病的突触可塑性反应和遗传途径有关联
Bjørn-Eivind Kirsebom,Johanna Nilsson,Ellen Vromen et al.
Bjørn-Eivind Kirsebom et al.
Background: Synapse loss is linked to cognitive symptoms in Alzheimer's Disease (AD) and Cerebrospinal fluid (CSF) synaptic biomarkers may clarify disease heterogeneity and disease mechanisms for progression beyond amyloi...
Midbrain degeneration triggers astrocyte reactivity and tau pathology in experimental Alzheimer's Disease [0.03%]
中脑退行性变触发实验性阿尔茨海默病小鼠的星形胶质细胞反应性和tau病理损害
Livia La Barbera,Paraskevi Krashia,Gilda Loffredo et al.
Livia La Barbera et al.
Background: Smaller midbrain volumes predict Alzheimer's Disease (AD) progression and faster conversion from Mild Cognitive Impairment (MCI) to dementia. Along with this, various midbrain-target areas are characterized by...
Correction: Lewy body dementia: exploring biomarkers and pathogenic interactions of amyloid β, tau, and α-synuclein [0.03%]
纠正路易体痴呆：探索淀粉样蛋白β、tau和α-突触核蛋白的生物标志物及致病互作
Jingfeng Liang,Rongzhen Li,Garry Wong et al.
Jingfeng Liang et al.
Published Erratum
Molecular neurodegeneration. 2025 Oct 9;20(1):106. DOI:10.1186/s13024-025-00902-4 2025
Brain somatic mutations in Alzheimer's disease: linking genetic mosaicism to neurodegeneration [0.03%]
阿尔茨海默病中的脑体细胞突变：遗传镶嵌与神经退行性病变之间的联系
Zuguang Li,Juan Zhang,Zhiqiang Liu et al.
Zuguang Li et al.
Somatic mutations are DNA sequence changes that occur in non-reproductive cells during an organism's life and are not inherited by offspring. Growing evidence implicates somatic mutations in Alzheimer's disease (AD), linking them to both di...
Molecular hallmarks of excitatory and inhibitory neuronal resilience to Alzheimer's disease [0.03%]
阿尔茨海默病兴奋性和抑制性神经元抗性的分子特征
Isabel Castanho,Pourya Naderi Yeganeh,Carles A Boix et al.
Isabel Castanho et al.
Background: A significant proportion of individuals maintain cognition despite extensive Alzheimer's disease (AD) pathology, known as cognitive resilience. Understanding the molecular mechanisms that protect these individ...
Microglia networks within the tapestry of alzheimer's disease through spatial transcriptomics [0.03%]
空间转录组学揭示的小胶质细胞在阿尔茨海默病中的网络作用
Yi Zhou,Christopher K Glass
Yi Zhou
Understanding Alzheimer's disease (AD) at the cellular level requires insights into how diverse cell types respond to hallmark pathologies, including amyloid plaques and tau aggregates. Although single-cell transcriptomic approaches have il...
Lauren K Wareham,David J Calkins
Lauren K Wareham
Microglia are resident immune cells of the central nervous system (CNS) and critical regulators of neural homeostasis, mediating immune surveillance, synaptic remodeling, debris clearance, and inflammatory signaling. Emerging evidence highl...
The Hippo signaling pathway as a therapeutic target in Alzheimer's disease [0.03%]
鲸鱼信号通路可作为阿尔茨海默病的治疗靶点
Doris Chen,Stella Wigglesworth-Littlewood,Frank J Gunn-Moore
Doris Chen
The Hippo signaling pathway is well-known for its regulation of organ size, cell proliferation, apoptosis, and cell migration and differentiation. Recent studies have demonstrated that Hippo signaling also plays important roles in the nervo...