The complement cascade in Alzheimer's disease: modern implications of an ancient immune protagonist [0.03%]
补体级联反应与阿尔茨海默病：一个古老免疫参与者在现代的含义
Maria-Tzousi Papavergi,Praveen Bathini,Brijendra Singh et al.
Maria-Tzousi Papavergi et al.
Targeted deletion of EMMPRIN in microglia/macrophages mitigates neuronal death in intracerebral hemorrhage [0.03%]
靶向删除EMMPRIN可减轻颅内出血中的神经元死亡
Zhe Li,Xiangyu Zhang,Maryam Mobarakabadi et al.
Zhe Li et al.
The pesticide chlorpyrifos increases the risk of Parkinson's disease [0.03%]
农药氯吡 triflate 增加帕金森病的风险
Kazi Md Mahmudul Hasan,Lisa M Barnhill,Kimberly C Paul et al.
Kazi Md Mahmudul Hasan et al.
Diagnostic biomarkers for α-synucleinopathies- state of the art and future developments: a systematic review [0.03%]
系统综述：诊断生物标志物在α-突触核蛋白病中的研究现状及未来发展方向
V Donadio,M Ingelsson,G Rizzo et al.
V Donadio et al.
DAP12 deletion reduces neuronal SLIT2 and demyelination and enhances brain resilience in female tauopathy mice [0.03%]
DAP12缺失减少tau病雌性小鼠神经元SLIT2和脱髓鞘并增强大脑韧性
Hao Chen,Li Fan,Qi Guo et al.
Hao Chen et al.
Background: Pathogenic tau accumulation drives neurodegeneration in Alzheimer's disease (AD). Enhancing the aging brain's resilience to tau pathology would lead to novel therapeutic strategies. DAP12 (DNAX-activation prot...
Domain mapping of disease mutations reveals pathogenic SORL1 variants in Alzheimer's disease [0.03%]
基于疾病突变的靶基因功能域分析揭示了与阿尔茨海默病致病相关的新基因SORL1
Olav M Andersen,Matthijs W J de Waal,Giulia Monti et al.
Olav M Andersen et al.
Background: Protein truncating variants (PTVs) in SORL1 are observed almost exclusively in Alzheimer’s Disease (AD) cases, but the effect of rare SORL1 missense variants is unclear. ...
Pioglitazone modulates metabolic adaptation and peripheral nerve regeneration after injury [0.03%]
吡格列酮调节损伤后的代谢适应和外周神经再生
Antonia Seitz,Taylan Özöncü,Daniela Sinske et al.
Antonia Seitz et al.
Peripheral nerves have an intrinsic capacity for regeneration after traumatic injury, with Schwann cells (SCs) playing a central role in orchestrating this complex process. Critical components of successful regeneration include SC reprogram...
Multidomain therapy for Alzheimer's disease: a scoping review of cognitive decline trials [0.03%]
阿尔茨海默病认知衰退临床试验的多领域治疗研究：系统性综述
Jared C Roach,Gwênlyn Glusman,Molly K Rapozo et al.
Jared C Roach et al.
Death-associated protein kinase 1-dependent SENP1 degradation increases tau SUMOylation and leads to cognitive dysfunction in a mouse model for tauopathy [0.03%]
依赖于死亡相关蛋白激酶1的SENP1降解通过增加tau-SUMO化导致Tau病小鼠模型中的认知功能障碍
Xindong Shui,Xiaoqing Zheng,Jinfeng Wu et al.
Xindong Shui et al.
Background: Emerging evidence implicates that tau SUMOylation disrupts tau homeostasis. Death-associated protein kinase 1 (DAPK1) has been shown to affect tau phosphorylation and accumulation. The sentrin-specific proteas...
High-sensitivity plasma proteomics reveals disease-specific signatures and predictive biomarkers of Alzheimer's disease phenotypes in a large mixed-dementia cohort [0.03%]
高灵敏血浆蛋白质组学揭示了阿尔茨海默病表型的大规模混合痴呆队列中的疾病特异性标志物和预测生物标志物
Katherine Gong,Jigyasha Timsina,Muhammad Ali et al.
Katherine Gong et al.
Novel plasma assays enabled accurate blood-based biomarkers for neurodegenerative diseases with minimally invasive options for clinical use. Large-scale studies encompassing multiple neurodegenerative diseases using novel multiplex platform...