Synaptic control of retinal ganglion cell survival and axon regeneration [0.03%]
调节视网膜节细胞存活和轴突发育的突触机制研究进展
Yuxuan Qiu,Qi Zhang,Jiahui Tang et al.
Yuxuan Qiu et al.
Tau oligomers modulate synapse fate by eliciting progressive bipartite synapse dysregulation and synapse loss [0.03%]
tau寡聚体通过诱发双部位突触调控异常和突触丧失来调节突触命运
Kristeen A Pareja-Navarro,Christina D King,Grant Kauwe et al.
Kristeen A Pareja-Navarro et al.
Plasma platelet-derived growth factor receptor-β decrease correlates with blood-brain barrier damage in Alzheimer's disease [0.03%]
血浆血小板衍生的生长因子受体-β减少与阿尔茨海默病的血脑屏障损伤相关
Jieyin Li,Anqi Li,Chenghui Ye et al.
Jieyin Li et al.
Systemic complement factors in aging, Alzheimer's disease and other dementias: a longitudinal study over 10 years [0.03%]
补体系统因素在衰老、阿尔茨海默病和其他痴呆症中的作用：为期10年的纵向研究
Xiaofeng Fu,Huimin Cai,Shuiyue Quan et al.
Xiaofeng Fu et al.
Background: Complement dysregulation is increasingly recognized in Alzheimer's disease (AD). However, the temporal profile of complement alterations preceding AD onset and their distinction from age-related immune changes...
The molecular fidelity of Aβ pathology in 5xFAD and AppNL-FPsen1P117L mice revealed by cryo-EM [0.03%]
利用冷冻电镜揭示5xFAD和AppNL-FFN1P117L小鼠中淀粉样蛋白病理的分子保真度
Meinai Song,Hanrun Zheng,Jianting Han et al.
Meinai Song et al.
Neuronal subtype governs amyloid structure, cellular response, and cognitive outcome in genetically targeted APP mouse models [0.03%]
神经元亚型决定淀粉样蛋白结构、细胞反应和遗传靶向APP小鼠模型的认知结果
Gabriella A Perez,Zoe Lai,George A Edwards Iii et al.
Gabriella A Perez et al.
Pathological heterogeneity is increasingly appreciated in Alzheimer’s disease, yet we do not know how distinct aggregate conformations arise or influence cognitive outcomes. In an amyloid mouse model, we found that different brain regions ...
Michael R Duggan,Hamilton Se-Hwee Oh,Philipp Frank et al.
Michael R Duggan et al.
Background: Biofluid proteomics can enhance our understanding of the neurodegenerative mechanisms underlying Alzheimer's disease and related dementias (ADRDs). Oligodendrocyte myelin glycoprotein (OMG) is a brain-specific...
Developmental dopamine loss rewires striatal circuits to promote locomotion [0.03%]
多巴胺发育性丢失重塑纹状体环路以促进运动行为
Jie Dong,Breanna T Sullivan,Victor M Martinez Smith et al.
Jie Dong et al.
Organelle stress in NLRP3 inflammasome: a central mediator of neurodegenerative diseases [0.03%]
NLRP3炎症小体中的细胞器应激在神经退行性疾病中的中心地位
Huachao Jia,Lianghua Ma,Jinyue Liu et al.
Huachao Jia et al.
Disrupting α-Synuclein-ClpP interaction restores mitochondrial function and attenuates neuropathology in Parkinson's disease models [0.03%]
干扰α-突触核蛋白-ClpP相互作用可恢复帕金森病模型中的线粒体功能并减轻神经病理学损伤
Di Hu,Xiaoyan Sun,Xin Qi
Di Hu
Background: Mitochondrial dysfunction and α-Synuclein (αSyn) aggregation are defining features of Parkinson's disease (PD), yet the mechanistic link between them remains poorly understood. Although our previous findings...